Diuretic activity of Phyllanthus niruri (Linn.) in rats

Udupa, Alaya Laxminarayana; Sanjeeva,; Benegal, Adarsh; Prusty, Vinay; Kodancha, G. Prabhath; Kumar, Manoj; Bhat, Vinutha; P, Ratnakar U

doi:10.4236/health.2010.25076

Cited by 5 publications

(4 citation statements)

References 2 publications

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“…This might be due to the inherent antioxidant and free-radical-scavenging principle(s) in the extract (Adeneye et al, 2008). Aqueous extract of P. niruri has significant diuretic activity, and it has significantly increased the excretion of sodium, potassium, and chloride as compared to that of the control (Udupa et al, 2010). In the present study, the histological examination revealed minimal damage to the brain, liver, and kidney in animals that received P. amarus after the termination of arsenic in the current study, it is evident that P. amarus can cause regeneration of tissues caused by arsenic.…”

Section: Discussionmentioning

confidence: 99%

Effect of Phyllanthus amarus in sodium arsenite-induced tissue damage

Hashim

Prasanna

Nizamudeen

2022

Bangladesh J Pharmacol

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This study aims to evaluate the effect of alcoholic extract of Phyllanthus amarus leaves on arsenic-induced histological changes in Wistar rats. Rats were divided into 4 groups: Group I: normal control; Group II: rats received sodium arsenite (40 mg/kg); Group III: rats received sodium arsenite (40 mg/kg) + P. amarus extract (100 mg/kg); Group IV: rats received sodium arsenite (40 mg/kg) + extract (200 mg/kg). All groups were treated by oral gavage with sodium arsenite for 28 days and the animals were subsequently administered (oral) with 100 and 200 mg/kg extract, once daily for two weeks. Animals were sacrificed 24 hours after the last treatment and different organs were collected for histopathological analysis. Results revealed mild to severe type of necrosis and degenerative changes in brain, kidney, and liver of arsenic fed animals. In rats administered with extract showed significant improvements, and the normal histological feature of the cells was almost restored in rats. These suggest that P. amarus can be used to treat arsenic-induced multi-organ damages.

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Section: Discussionmentioning

confidence: 99%

Effect of Phyllanthus amarus in sodium arsenite-induced tissue damage

Hashim

Prasanna

Nizamudeen

2022

Bangladesh J Pharmacol

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“…It is possible that the patients were aware of the importance of fluid intake to prevent the formation of new calculi and were thus already consuming the quantity of liquid recommended at the beginning of the study; this would have resulted in no significant change in urine volume. The diuretic effects of P. niruri have been described in experimental studies ( 10 , 15 ), though Nishiura et al ( 11 ) reported different results in a clinical study.…”

Section: Discussionmentioning

confidence: 99%

Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention

et al. 2018

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Phyllanthus niruri (P.niruri) or stone breaker is a plant commonly used to reduce stone risk, however, clinical studies on this issue are lacking.Objective:To prospectively evaluate the effect of P. niruri on the urinary metabolic parameters of patients with urinary lithiasis.Materials and Methods:We studied 56 patients with kidney stones <10mm. Clinical, metabolic, and ultrasonography assessment was conducted before (baseline) the use of P. niruri infusion for 12-weeks (P. niruri) and after a 12-week (wash out) Statistical analysis included ANOVA for repeated measures and Tukey's/McNemar's test for categorical variables. Significance was set at 5%.Results:Mean age was 44±9.2 and BMI was 27.2±4.4kg/m2. Thirty-six patients (64%) were women. There were no significant changes in all periods for anthropometric and several serum measurements, including total blood count, creatinine, uric acid, sodium, potassium, calcium, urine volume and pH; a significant increase in urinary potassium from 50.5±20.4 to 56.2±21.8 mg/24-hour (p=0.017); magnesium/creatinine ratio 58±22.5 to 69.1±28.6mg/gCr24-hour (p=0.013) and potassium/creatinine ratio 39.3±15.1 to 51.3±34.7mg/gCr24-hour (p=0.008) from baseline to wash out. The kidney stones decreased from 3.2±2 to 2.0±2per patient (p<0.001). In hyperoxaluria patients, urinary oxalate reduced from 59.0±11.7 to 28.8±16.0mg/24-hour (p=0.0002), and in hyperuricosuria there was a decrease in urinary uric acid from 0.77±0.22 to 0.54±0.07mg/24-hour (p=0.0057).Conclusions: P.niruri intake is safe and does not cause significant adverse effects on serum metabolic parameters. It increases urinary excretion of magnesium and potassium caused a significant decrease in urinary oxalate and uric acid in patients with hyperoxaluria and hyperuricosuria. The consumption of P.niruri contributed to the elimination of urinary calculi.

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“…The role of Chrysanthellum americanum in the management of urinary stones is due to its interference, through the chrysantellin, a saponin, with some stages of crystallization in urine, such as a reduction in the nucleation, growth and aggregation of calcium oxalate crystals (8). Moreover, the synergistic effect of Phyllanthus niruri and Chrysanthellum americanum is probably due to its diuretic effects (12,13). Furthermore, this food supplement contains potassium and magnesium citrates, although previous studies did not favor potassium citrate therapy.…”

Section: Role Of Phytotherapy In the Management Of Urinary Stones And Mechanism Of Actionmentioning

confidence: 99%

Phyllanthus niruri and Chrysanthellum americanum in association with potassium and magnesium citrates are able to prevent symptomatic episode in patients affected by recurrent urinary stones: A prospective study

Cai

Tiscione

Puglisi

et al. 2021

Arch Ital Urol Androl

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Objective: The aim of this study is to evaluate the efficacy of a food supplement containing Phyllanthus niruri and Chrysanthellum americanum in association with potassium and magnesium citrates in the treatment and prophylaxis of urinary stones. Materials and methods: Eighty-two patients (mean age 49.7 ± 11.2) with history of urinary stones received this food supplement, one capsule a day for 6 months. Each administration contained a combination of the following ingredients: 244 mg Potassium citrate, 735 mg Magnesium citrate, Phyllanthus (Phyllantus niruri) herb d.e. 15% mg Tannins 220 mg, Chrysanthellum (Chrysanthellum americanum Vatke) plant d.e. ¼ 55 mg. After 6 months, all patients underwent urologic visit, urinalysis, imaging and quality of life (QoL) questionnaires evaluation. Each patient was also evaluated by computed tomography (CT) scan at baseline and at 6 months. Result: From January 2018 to March 2019, 82 patients (mean age 49.7 ± 11.2) completed the follow-up period and were analyzed. Fifty patients showed lower stone dimensions (60.9%). The average stone size was 0.9 mm, with a significant reduction in comparison with the baseline (-6.7 mm ± 3 mm) (p < 0.001). Forty-nine patients (59.7%) did not show any symptomatic episode with an improving in QoL (+0.4 ± 0.1) (p < 0.001) in comparison with the baseline. At the end of the follow-up period, 27 patients out of 82 were stone-free (32.9%). Moreover, we report a significant reduction of patients with asymptomatic bacteriuria (ABU) between the baseline and the end of the follow-up evaluation (p < 0.001). Conclusions: In conclusion, this food supplement is able to improve quality of life in patients with urinary stones, reducing symptomatic episodes and the prevalence of ABU.

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Diuretic activity of Phyllanthus niruri (Linn.) in rats

Cited by 5 publications

References 2 publications

Effect of Phyllanthus amarus in sodium arsenite-induced tissue damage

Effect of Phyllanthus amarus in sodium arsenite-induced tissue damage

Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention

Phyllanthus niruri and Chrysanthellum americanum in association with potassium and magnesium citrates are able to prevent symptomatic episode in patients affected by recurrent urinary stones: A prospective study

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