Diurnal Intraocular Pressure Curves in Healthy Rhesus Macaques (Macaca mulatta) and Rhesus Macaques With Normotensive and Hypertensive Primary Open-Angle Glaucoma

Komàromy, András M.; Brooks, Dennis; Kubilis, Paul; Dawson, William W.; Sapp, Harold L.; Nelson, Grant S.; Collins, Bobby R.; Sherwood, Mark B.

doi:10.1097/00061198-199804000-00011

Cited by 24 publications

(30 citation statements)

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“…A series of subsequent reports (Dawson et al, 1998; Dawson et al, 2005; Komaromy et al, 1998; Toris et al, 2010) defined a variety of ocular and demographic characteristics of subsets of animals, but the genetics of the colony and the histologic features of the neuropathy have not yet been described. A second small group of ocular hypertensive animals has been identified within an NHP colony in Singapore.…”

Section: Spontaneous Nhp Glaucoma and Other Spontaneous Nhp Optic Neumentioning

confidence: 99%

The non-human primate experimental glaucoma model

Burgoyne

2015

Experimental Eye Research

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The purpose of this report is to summarize the current strengths and weaknesses of the non-human primate (NHP) experimental glaucoma (EG) model through sections devoted to its history, methods, important findings, alternative optic neuropathy models and future directions. NHP EG has become well established for studying human glaucoma in part because the NHP optic nerve head (ONH) shares a close anatomic association with the human ONH and because it provides the only means of systematically studying the very earliest visual system responses to chronic IOP elevation, i.e. the conversion from ocular hypertension to glaucomatous damage. However, NHPs are impractical for studies that require large animal numbers, demonstrate spontaneous glaucoma only rarely, do not currently provide a model of the neuropathy at normal levels of IOP, and cannot easily be genetically manipulated, except through tissue-specific, viral vectors. The goal of this summary is to direct NHP EG and non-NHP EG investigators to the previous, current and future accomplishment of clinically relevant knowledge in this model.

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Section: Spontaneous Nhp Glaucoma and Other Spontaneous Nhp Optic Neumentioning

confidence: 99%

The non-human primate experimental glaucoma model

Burgoyne

2015

Experimental Eye Research

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“…Despite contradictory findings, the most widely held conclusion is that decreased IOP correlates positively with increased intraocular melatonin levels (Rohde et al, 1985;Komaromy et al, 1998;Pointer, 1997). However, pharmacological characterization of melatonin receptors reveals three receptor subtypes (MT 1, MT 2 , and MT 3 ; Dubocovich, 1995) and that the relationship between individual receptor subtypes and IOP has not been evaluated comprehensively.…”

Section: Introductionmentioning

confidence: 99%

Design of Novel Melatonin Analogs for the Reduction of Intraocular Pressure in Normotensive Rabbits

Alarma-Estrany

Guzmán-Aránguez²,

Huete³

et al. 2011

J Pharmacol Exp Ther

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“…In IOP experiments with animals, ketamine increases IOP in dogs, rabbits and cats,7-9 but decreases IOP in rats 10. For non-human primates, however, most studies show that ketamine does not significantly affect IOP 11-13…”

Section: Introductionmentioning

confidence: 99%

Effect of Daily Prolonged Ketamine Anesthesia on Intraocular Pressure in Monkeys

Bunch

Tian

Seeman

et al. 2008

Current Eye Research

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Purpose-To determine if repeated intramuscular ketamine in monkeys on consecutive days affects intraocular pressure (IOP), and if the ketamine-induced IOP change has any relationship to systemic dehydration and/or changes in mean arterial pressure (MAP) of the animals.Methods-Nine monkeys were studied per 4 protocols. IOP was determined hourly for 6-hrs by Goldmann tonometry under ketamine anesthesia on 3 (protocol 1) or 5 (protocols 2 and 3) consecutive days, or on alternating days 1, 3 and 5 (protocol 4). Monkeys in protocols 3 and 4, but not in protocols 1 and 2, received subcutaneous Ringer's fluids at the end of each 6-hr session on days 1-4 or 1, 3 and 5; monkeys in protocols 2 and 3 received intravenous fluid infusion throughout the experiment on day 5. In protocols 2-4, MAP was measured hourly following each IOP measurement.Results-Monkeys receiving ketamine but no Ringer's fluids in protocol 1 or 2 showed significant IOP declines on days 2-3 or 2-4. The IOP declines were greater in magnitude in protocol 1 than in protocol 2. Daily subcutaneous Ringer's fluids appeared to delay IOP declines in protocol 3. Continuous intravenous fluid infusion on day 5 variably prevented IOP declines in protocols 2 and 3. Monkeys receiving ketamine and subcutaneous fluids on alternate days in protocol 4 showed no decline in IOP. No significant relationship between IOP and MAP was observed.Conclusions-Anesthesia induced by repeated intramuscular ketamine on consecutive days may produce significant IOP declines. Systemic dehydration during the anesthesia seems to be the predominant factor contributing to the IOP reduction. However, inter-individual differences in monkeys indicate that multiple factors may be involved. This study also suggests that fluid supplementation plus alternating anesthesia with recovery days may prevent IOP reduction in monkeys resulting from daily-prolonged ketamine anesthesia.

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Diurnal Intraocular Pressure Curves in Healthy Rhesus Macaques (Macaca mulatta) and Rhesus Macaques With Normotensive and Hypertensive Primary Open-Angle Glaucoma

Cited by 24 publications

References 0 publications

The non-human primate experimental glaucoma model

The non-human primate experimental glaucoma model

Design of Novel Melatonin Analogs for the Reduction of Intraocular Pressure in Normotensive Rabbits

Effect of Daily Prolonged Ketamine Anesthesia on Intraocular Pressure in Monkeys

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