Diurnal Pattern of Plasma and Cerebrospinal-Fluid Vasopressin Levels in Hydrocephalic Patients: Absence of a Circadian Rhythm and of a Correlation between Plasma and Cerebrospinal-Fluid Variations

Barreca, T; Franceschini, R.; Siani, C; Messina, Valeria; Francaviglia, Natale; Perria, C; Rolandi, E

doi:10.1159/000181022

Cited by 10 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whether this is true of all age groups is not known. Studies on the diurnal rhythm of ADH are, with few exceptions, performed in paediatric cases with enuresis [5, 81, or in very specific research [9].…”

Section: Discussionmentioning

confidence: 99%

Diurnal variation in the levels of antidiuretic hormone in the elderly

Asplund

Åberg

1991

Journal of Internal Medicine

227

103

View full text Add to dashboard Cite

The secretion of antidiuretic hormone (ADH) and the serum osmolality were measured at 4-h intervals throughout a 24-h period in 69 healthy elderly volunteers. In male subjects the concentrations of plasma ADH were always twofold higher than in female subjects. The normal diurnal rhythm, with increased ADH secretion during the night, was not seen in this group of elderly subjects, with the exception of elderly men who did not urinate during the night, in whom a substantial increase in plasma ADH levels occurred. In as many as 25% of all the ADH measurements performed (n = 455) ADH was not detectable by the method used. The lack of a definite diurnal rhythm in most of the elderly subjects could to some extent explain the increased diuresis during the night in the elderly.

show abstract

Section: Discussionmentioning

confidence: 99%

Diurnal variation in the levels of antidiuretic hormone in the elderly

Asplund

Åberg

1991

Journal of Internal Medicine

227

103

View full text Add to dashboard Cite

show abstract

“…In people under 50 years old, Avp content within the SCN shows a clear circadian pattern; this pattern is reversed in those over 50 (Hofman and Swaab, 1994). The diurnal rhythm of Avp is reported to be absent in patients with hydrocephalus (Barreca et al, 1988). Patients with Alzheimer's disease have over 30% less Avp mRNA in the SCN than do healthy age-matched persons Ishunina and Swaab, 2002).…”

Section: Regulation Of Behavior By the Suprachiasmatic Nucleusmentioning

confidence: 99%

Vasopressin: Behavioral roles of an “original” neuropeptide

Caldwell

Lee

Macbeth

et al. 2008

Progress in Neurobiology

427

416

View full text Add to dashboard Cite

Vasopressin (Avp) is mainly synthesized in the magnocellular cells of the hypothalamic supraoptic (SON) and paraventricular nuclei (PVN) whose axons project to the posterior pituitary. Avp is then released into the blood stream upon appropriate stimulation (e.g., hemorrhage or dehydration) to act at the kidneys and blood vessels. The brain also contains several populations of smaller, parvocellular neurons whose projections remain within the brain. These populations are located within the PVN, bed nucleus of the stria terminalis (BNST), medial amygdala (MeA) and suprachiasmatic nucleus (SCN).Since the 1950's, research examining the roles of Avp in the brain and periphery has intensified. The development of specific agonists and antagonists for Avp receptors has allowed for a better elucidation of its contributions to physiology and behavior. Anatomical, pharmacological and transgenic, including "knockout," animal studies, have implicated Avp in the regulation of various social behaviors across species.Avp plays a prominent role in the regulation of aggression, generally of facilitating or promoting it. Affiliation and certain aspects of pair-bonding are also influenced by Avp. Memory, one of the first brain functions of Avp that was investigated, has been implicated especially strongly in social recognition. The roles of Avp in stress, anxiety, and depressive states are areas of active exploration. In this review, we concentrate on the scientific progress that has been made on understanding the role of Avp in regulating of these and other behaviors across species, as well as discuss the implications for human behavior.

show abstract

“…The time of day when the blood samples were obtained was rarely given in above quoted studies. However, because neither the CSF nor plasma levels show a significant circadian rhythm in adult humans (Barreca et al, ; Mahler et al, ), the difference in plasma levels obtained in these studies cannot be due to variations in circadian time between study groups. We have in this study not been able to obtain information about medication, including neuroleptics, taken by the controls and schizophrenic patients.…”

Section: Discussionmentioning

confidence: 80%

Expression of vasopressin mRNA in the hypothalamus of individuals with a diagnosis of schizophrenia

et al. 2019

View full text Add to dashboard Cite

Objective This study investigates the expression of mRNA encoding vasopressin in the hypothalamus of autopsy brains of individuals diagnosed with schizophrenia. Methods Ten brains of individuals with schizophrenia and 10 brains from individuals without any disease were examined during autopsy. The hypothalamic block was dissected and immersion fixed in paraformaldehyde, sucrose substituted, frozen, and cut into 20‐µm‐thick coronal cryostat sections. The sections were hybridized with an S‐35‐labeled DNA antisense oligo probe and after washing covered by an X‐ray film. The hybridization signals on the films were transferred to a computer and densitometrically quantified. Results The densitometry signals showed a statistically significant lower mRNA expression (53% decrease; p = 0.014) in the paraventricular nucleus of the individuals with schizophrenia compared to the controls. In the supraoptic nucleus, the decrease in the group with schizophrenia was 39% compared to the controls, but this decrease was not statistically significant (p = 0.194). Conclusions Our results show a low expression of mRNA encoding vasopressin in the paraventricular nucleus of the individuals with schizophrenia. We suggest that vasopressin is not directly involved in the pathogenesis of schizophrenia, but might influence schizophrenic symptoms via vasopressin receptors located in the social behavioral neural network in the forebrain.

show abstract

Diurnal Pattern of Plasma and Cerebrospinal-Fluid Vasopressin Levels in Hydrocephalic Patients: Absence of a Circadian Rhythm and of a Correlation between Plasma and Cerebrospinal-Fluid Variations

Cited by 10 publications

References 0 publications

Diurnal variation in the levels of antidiuretic hormone in the elderly

Diurnal variation in the levels of antidiuretic hormone in the elderly

Vasopressin: Behavioral roles of an “original” neuropeptide

Expression of vasopressin mRNA in the hypothalamus of individuals with a diagnosis of schizophrenia

Contact Info

Product

Resources

About