Diurnal variability in urinary volatile organic compound metabolites and its association with oxidative stress biomarkers

Human Exposure Levels of Volatile Organic Compounds in E-waste Recycling Area: Get Insight into Impacts of Manipulation Mode and Associations with Oxidative Stress Markers

“…A dilute-and-shoot assay was used to analyze urinary mVOCs, cotinine, and OSBs, which was described elsewhere with slight modification. , Briefly, 50 μL of urine was diluted to 0.5 mL with 15 mM ammonium acetate solution containing 5 ng (for OSBs) or 25 ng (for mVOCs and cotinine) of each surrogate standards. The mixture was transferred into a 2 mL HPLC vial for instrumental analysis after spinning through a nylon filter.…”

“…The noninvasive detection of metabolites in conventional diagnostic matrices, such as urine, could help address this issue . Compared with their parent compounds, VOC metabolites (mVOCs) have long physiological half-lives and are regarded as specific biomarkers used for assessing people’s VOC exposure in various environments. ,, Nevertheless, only two studies have explored the urinary metabolic biomarkers of exposure to VOCs from e-waste disassembly sites; one in adolescents and one in adult workers. , Under the impact of the manipulation mode, data on levels of multiple urinary mVOCs are limited.…”

Construction of Models To Predict the Effectiveness of E-Waste Control through Capture of Volatile Organic Compounds and Metals/Metalloids Exposure Fingerprints: A Six-Year Longitudinal Study

“…The concentration ratio of 2-HPMA/3-&4-MHA in Guiyu ER children recruited in 2021 (0.03) is significantly lower compared with that in other reference areas, including children aged 6–11 in the 2015–2016 NHANES dataset (0.187) and children aged <7 in south and central China (0.323) . Conversely, the concentration ratios of MA/3-&4-MHA in e-waste recycling workers (3.36) and Guiyu ER children recruited in 2021(1.87) are much higher relative to that of other reference areas, such as children aged 6–11 in the 2015–2016 NHANES dataset (0.828) and healthy adults in the United States (0.905) . MA and 3-&4-MHA are urinary exposure biomarkers of styrene and m -& p -xylene, respectively .…”

Occurrence of and dermal exposure to benzene, toluene and styrene found in hand sanitizers from the United States

“…Exposure to benzene causes leukemia and other non-cancerous effects such as neurological, cardiovascular, gastrointestinal, reproductive and renal toxicities ( Pal et al, 2022 ; CDC, 2021 ; Li et al, 2021 ; ATSDR, 2007a , 2007b ; Lamm, 2006 ; Jones et al, 1991 ). Toluene is sequestered in fatty tissues and brain, and exposure can result in renal toxicity, myocardial infarction, cardiac arrhythmias, depression and reproductive toxicities ( ATSDR, 2017 ; Li et al, 2021 ).…”