Diurnal variation in sperm DNA fragmentation: analysis of 11,382 semen samples from two populations and<i>in vivo</i>animal experiments

Ni, Wuhua; Liu, Kun; Hou, Guizhong; Pan, Chengshuang; Wu, Suichun; Zheng, Jinhuan; Cao, Jia; Chen, Qing; Huang, Xuefeng

doi:10.1080/07420528.2019.1649275

Cited by 13 publications

(12 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the quality of semen changed both diurnally and seasonally [7]: semen samples collected in the early morning showed the highest levels in sperm concentration, total sperm count and normal morphology. Evidence for daily diurnal variance in sperm DNA fragmentation index was demonstrated both in man and mice [8]. In addition to diurnal variation in sperm parameters, seasonal variation has been reported in several studies.…”

Section: Introductionmentioning

confidence: 87%

The role of circadian rhythm in male reproduction

Peterlin¹,

Kunej

Peterlin

2019

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

View full text Add to dashboard Cite

Purpose of reviewTo integrate evidence on the role of circadian rhythm in male reproduction. Several studies report on various aspects of the association between the circadian system and male reproductive function in animals and humans both in physiological condition as well as in the case of subfertility. Recent findingsEpidemiological data demonstrate diurnal and seasonal changes as well as the effect of sleep/wake cycles on the quality of semen. Rare and common genetic variation in circadian clock genes in humans and animal models support the role of circadian rhythms in male fertility in humans. SummaryCurrent data support the modest effect of the circadian clock on male reproductive potential; however, the evidence available is still fragmented and inconclusive. Additional well designed and sufficiently powered studies are needed to delineate the role of the circadian clock both in cause and potential interventional and preventive approaches in male subfertility.

show abstract

Section: Introductionmentioning

confidence: 87%

The role of circadian rhythm in male reproduction

Peterlin¹,

Kunej

Peterlin

2019

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

View full text Add to dashboard Cite

show abstract

“…Diurnal rhythms of sperm count, sperm motility, and sperm chromatin integrity have been found in rodents. There are also several studies which have investigated the diurnal variation of semen parameters in humans ( Ni et al, 2019 ; Sati, 2020 ). Variations in semen parameters were found across different time points in most of the studies, although a high-resolution sampling study is required to confidently profile the circadian pattern.…”

Section: Circadian Physiology In Major Organs Associated With Complex Diseasementioning

confidence: 99%

Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease

Xin

Yuan

et al. 2021

Front. Genet.

Self Cite

View full text Add to dashboard Cite

The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles of environmental light. Fundamental mechanisms of how the circadian clock regulates organ physiology and metabolism have been elucidated at a rapid speed in the past two decades. Here we review circadian networks in more than six organ systems associated with complex disease, which cluster around metabolic disorders, and seek to propose critical regulatory molecules controlled by the circadian clock (named clock-controlled checkpoints) in the pathogenesis of complex disease. These include clock-controlled checkpoints such as circadian nuclear receptors in liver and muscle tissues, chemokines and adhesion molecules in the vasculature. Although the progress is encouraging, many gaps in the mechanisms remain unaddressed. Future studies should focus on devising time-dependent strategies for drug delivery and engagement in well-characterized organs such as the liver, and elucidating fundamental circadian biology in so far less characterized organ systems, including the heart, blood, peripheral neurons, and reproductive systems.

show abstract

“…However, caution is needed for the use of serotonin in infertility treatment or male contraception and further studies are definitely required. In addition, Ni and colleagues recently reported interesting data from 11,382 semen samples from two populations and in vivo animal experiments demonstrating that sperm DNA fragmentation index (DFI) may undergo diurnal variation (Ni et al 2019). These data are important since the existence of a circadian rhythm in DFI can explain the conflicting results observed in different studies related to sperm DFI since the 'timing' of the sample collection is not always considered.…”

Section: The Role Of Circadian System In Male Reproductive Biologymentioning

confidence: 99%

“…Hodzic et al (2013) Patients with idiopathic infertility (n = 517) and fertile men (n = 444)Genetic variability in CLOCK associated with male infertilityMao et al (2017) Cases for routine semen analysis (n = 8168), morphology ( n = 5819) and anti-sperm antibodies analysis (n = 5544)Positive correlation between increased length of daylight and progressive sperm motilityXie et al (2018) 12,245 semen samples (n = 7068 men) Circadian and circannual variations on semen qualityNi et al (2019) Human semen samples (n = 10,752) Diurnal variations on sperm DNA fragmentation Chronobiology, reproduction and offspring healthR85Reproduction (2020) 160 R79-R94…”

mentioning

confidence: 99%

Chronodisruption: effects on reproduction, transgenerational health of offspring and epigenome

Satı

2020

Reproduction

View full text Add to dashboard Cite

The circadian system regulates the daily temporal organization in behavior and physiology, including neuroendocrine rhythms and reproduction. Modern life, however, increasingly impacts this complex biological system. Due to limitations of working with human subjects exposed to shiftwork schedules, most chronoregulation research has used rodent models. Recent publications in these model systems have emphasized the negative effects of circadian rhythm disruption on both female and male reproductive systems and fertility. Additionally, there is growing concern about the long-term effects of circadian rhythm disruptions during pregnancy on human offspring and their descendants as circadian regulation during pregnancy can also alter epigenetic programing in offspring. However, to truly know if such concerns apply to humans will require retrospective and prospective human studies. Therefore, this review will highlight the latest available evidence regarding potential effects of chronodisruption on both female and male reproductive systems. Additionally, it presents a comprehensive summary of transgenerational and epigenetic effects on adult offspring that result from maternal chronodisruption.

show abstract

Diurnal variation in sperm DNA fragmentation: analysis of 11,382 semen samples from two populations andin vivoanimal experiments

Cited by 13 publications

References 42 publications

The role of circadian rhythm in male reproduction

The role of circadian rhythm in male reproduction

Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease

Chronodisruption: effects on reproduction, transgenerational health of offspring and epigenome

Contact Info

Product

Resources

About