Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma

Tashkandi, Hammad; Petrova‐Drus, Kseniya; Batlevi, Connie Lee; Arcila, Maria E.; Roshal, Mikhail; Şen, Filiz; Yao, Jinjuan; Baik, Jeeyeon; Bilger, Ashley; Singh, Jaskirat; Frank, Stephanie De; Kumar, Anita; Aryeequaye, Ruth; Zhang, Yanming; Doğan, Ahmet; Xiao, Wenbin

doi:10.1101/mcs.a004259

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…A spectrum of background ranging from minimally associated inflammatory cells to a cHL-like mixed inflammatory population is reported [43]. Moreover, combined MCL and cHL lymphoma is also described and a divergent clonal evolution from a common precursor has been hypothesized [43,44], leading to RSLC in MCL and/or RSC in cHL combined with MCL because of EBV infection, acquisition of additional genetic aberrations such as PD-L1/2 amplification, and certain mutations such as TP53 [44,45] (Supplementary Table S2).…”

Section: Histological Findings and Immunophenotypementioning

confidence: 99%

Hodgkin Reed–Sternberg-Like Cells in Non-Hodgkin Lymphoma

et al. 2020

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Reed–Sternberg cells (RSCs) are hallmarks of classic Hodgkin lymphoma (cHL). However, cells with a similar morphology and immunophenotype, so-called Reed–Sternberg-like cells (RSLCs), are occasionally seen in both B cell and T cell non-Hodgkin Lymphomas (NHLs). In NHLs, RSLCs are usually present as scattered elements or in small clusters, and the typical background microenviroment of cHL is usually absent. Nevertheless, in NHLs, the phenotype of RSLCs is very similar to typical RSCs, staining positive for CD30 and EBV, and often for B cell lineage markers, and negative for CD45/LCA. Due to different therapeutic approaches and prognostication, it is mandatory to distinguish between cHL and NHLs. Herein, NHL types in which RSLCs can be detected along with clinicopathological correlation are described. Moreover, the main helpful clues in the differential diagnosis with cHL are summarized.

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Section: Histological Findings and Immunophenotypementioning

confidence: 99%

Hodgkin Reed–Sternberg-Like Cells in Non-Hodgkin Lymphoma

et al. 2020

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“…The etiology and pathogenesis of composite lymphoma are complex and variable. Several theories have been presumed including clonal selection, genomic instability, or common precursor cell [ 11 ]. The actual origin of the composite of MCL with HL is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Composite Classical Hodgkin Lymphoma and Mantle Cell Lymphoma: A Case Report

Kaur,

Zhang,

Zhang

et al. 2023

Cureus

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Composite lymphoma implies the presence of two or more morphological and immunophenotypical subtypes of lymphoma in a single tissue or organ. Composite lymphoma with concurrent mantle cell lymphoma (MCL) and classical Hodgkin lymphoma is extremely rare. In this case report, we present the case of a 70-year-old male who was diagnosed with a composite of MCL and classical Hodgkin lymphoma (cHL) and achieved near-complete resolution with chemoimmunotherapy. To the best of our knowledge, this is the first case of this kind demonstrating the effectiveness of a combination chemoimmunotherapy regimen leading to complete remission in composite lymphoma involving MCL and cHL. We report the history, imaging findings, and pathology and illustrate the challenges in therapeutic decision-making in managing composite lymphoma patients involving MCL and cHL. We also review the literature on this rare entity and discuss its clinical implications.

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“…NOTCH family members express in a variety of different tissues and play roles in a variety of developmental processes by controlling cell fate decisions. The gene fusion of SEC22B‐NOTCH2 has been confirmed in aggressive breast cancers and mantle cell lymphoma (Tashkandi et al, 2019; Veeraraghavan, Ma, Hu, & Wang, 2016). This gene fusion displays enhanced activation of the NOTCH pathway to promote the proliferation and survival of tumor cells (Robinson et al, 2011).…”

Section: The Roles Of Sec22b In Human Diseasesmentioning

confidence: 97%

The function of SEC22B and its role in human diseases

et al. 2020

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Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins are a large protein complex that is involved in the membrane fusion in vesicle trafficking, cell growth, cytokinesis, membrane repair, and synaptic transmission. As one of the SNARE proteins, SEC22B functions in membrane fusion of vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus, antigen cross-presentation, secretory autophagy, and other biological processes. However, apart from not being SNARE proteins, there is little knowledge known about its two homologs (SEC22A and SEC22C). SEC22B alterations have been reported in many human diseases, especially, many mutations of SEC22B in human cancers have been detected. In this review, we will introduce the specific functions of SEC22B, and summarize the researches about SEC22B in human cancers and other diseases. These findings have laid the foundation for further studies to clarify the exact mechanism of SEC22B in the pathological process and to seek new therapeutic targets and better treatment strategies.

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Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma

Cited by 9 publications

References 13 publications

Hodgkin Reed–Sternberg-Like Cells in Non-Hodgkin Lymphoma

Hodgkin Reed–Sternberg-Like Cells in Non-Hodgkin Lymphoma

Composite Classical Hodgkin Lymphoma and Mantle Cell Lymphoma: A Case Report

The function of SEC22B and its role in human diseases

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