Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/P-STAT3 pathways

Zhou, Yinlin; Zhang, Duan-Na; Qiao, Ji-Xu; Wu, Jing; Yan, Yong-Ming; Cao, Zhixing; Peng, Cheng; Tan, Yuzhu

doi:10.1016/j.phytochem.2022.113558

Phytochemistry

2023

DOI: 10.1016/j.phytochem.2022.113558

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Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/P-STAT3 pathways

Yinlin Zhou

Duan-Na Zhang

Ji-Xu Qiao

et al.

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Cited by 7 publications

References 42 publications

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Selective Activity Against Amastigote Forms of Trypanosoma cruzi and Leishmania infantum of Diastereomeric Dicentrine N‐oxides

Tristão,

Barbosa,

de Castro Levatti

et al. 2024

Chemistry & Biodiversity

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As part of our continuous research for the discovery of bioactive compounds against Trypanosoma cruzi and Leishmania infantum, the alkaloid (6aS)‐dicentrine (1) was oxidized to afford (6aS,6S)‐ (2) and (6aS,6R)‐ (3) dicentrine‐N‐oxides. Evaluation of the cytotoxicity against NCTC cells indicated that 2 and 3 are non‐toxic (CC50 > 200 μM) whereas 1 demonstrated CC50 of 52.0 μM. Concerning T. cruzi activity against amastigotes, derivatives 2 and 3 exhibited EC50 values of 9.9 μM (SI > 20.7) and 27.5 μM (SI > 7.3), respectively, but 1 is inactive (EC50 > 100 μM). Otherwise, when tested against L. infantum amastigotes, 1 and 3 exhibited EC50 values of 10.3 μM (SI = 5.0) and 12.7 μM (SI > 15.7), respectively, being 2 inactive (EC50 > 100 μM). Comparing the effects of positive controls benznidazol (EC50 = 6.5 μM and SI > 30.7) and miltefosine (EC50 = 10.2 μM and SI = 15.0), it was observed a selective antiparasitic activity to diastereomers 2 and 3 against T. cruzi and L. infantum. Considering stereochemical aspects, it was suggested that the configuration of the new stereocenter formed after oxidation of 1 played an important role in the bioactivity against amastigotes of both tested parasites.

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Selective Activity Against Amastigote Forms of Trypanosoma cruzi and Leishmania infantum of Diastereomeric Dicentrine N‐oxides

Tristão,

Barbosa,

de Castro Levatti

et al. 2024

Chemistry & Biodiversity

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Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells

Du,

Li,

Zheng

et al. 2023

Bioorganic Chemistry

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Two new anthranilamides with chemotaxonomic value from Delphinium tatsienense

Tu,

Chen,

Liu

et al. 2024

Biochemical Systematics and Ecology

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Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/P-STAT3 pathways

Cited by 7 publications

References 42 publications

Selective Activity Against Amastigote Forms of Trypanosoma cruzi and Leishmania infantum of Diastereomeric Dicentrine N‐oxides

Selective Activity Against Amastigote Forms of Trypanosoma cruzi and Leishmania infantum of Diastereomeric Dicentrine N‐oxides

Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells

Two new anthranilamides with chemotaxonomic value from Delphinium tatsienense

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