Diverse Applications of Nanomedicine

Abstract

The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

High-purified Isolation and Proteomic Analysis of Urinary Exosomes from Healthy Persons

“…The proteins belonged to several types and owned different functions, which can be used for screening disease biomarkes. If exosomes combine with nanotechnology, applications of exosomes in diagnosis and therapy will be improved greatly [33]. Our investigation lays foundation for further clarifying the theranostic mechanism of exosomes.…”

Nanomedicine in rheumatology: A new field in the diagnosis and therapy of rheumatic diseases

“…When nanocarriers and nanomedicine are injected in the blood, they can quickly adsorb blood proteins, a condition known as the 'protein corona'. The physicochemical properties including size, configuration, water affinity, elimination and catalytic capability all may influence their fate and subsequent biological responses [12,13]. The quick uptake of nanomedicine by reticuloendothelial system (RES) cells results in their high accumulation in the liver and spleen [12].…”

“…The physicochemical properties including size, configuration, water affinity, elimination and catalytic capability all may influence their fate and subsequent biological responses [12,13]. The quick uptake of nanomedicine by reticuloendothelial system (RES) cells results in their high accumulation in the liver and spleen [12]. Improving the drug delivery carrier's bio-distribution may be attained by including immune-evading moieties and/ or affinity molecules that support attachment to biomarkers according to the level of needed selectivity [14].…”

“…The use of biologics for the treatment of rheumatic diseases is rapidly expanding and parental administration has been the mainstay route of their delivery because they are too large to permeate epithelial barriers [12]. Inspite the effectiveness of biologics, major side effects occur [31] exposing patients to serious infections as tuberculosis [32].…”

“…Moreover, nanostructured surfaces introduce a potentially revolutionary approach to the delivery of biologics and influence on fibrosis in SSc [12].…”