Diverse associations of 25‐hydroxyvitamin D and 1,25‐dihydroxy‐vitamin D with dyslipidaemias

Karhapää, Pauli; Pihlajamäki, Jussi; Pörsti, Ilkka; Kastarinen, Mika; Mustonen, Jukka; Niemelä, Onni

doi:10.1111/j.1365-2796.2010.02279.x

Cited by 120 publications

(99 citation statements)

References 32 publications

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“…In addition, the associations may differ by sex considering the differences in body composition and serum lipid levels between women and men. Previous studies were mostly performed on ambulatory patients and/or vitamin Ddeficient, middle-aged or overweight and obese individuals and often without adjustments for potential confounders, such as the association between vitamin D and PTH, body composition, medical conditions and/or lifestyle factors, including sun exposure, physical activity and habitual diet (4)(5)(6)(7)9,(12)(13)(14)(15) .…”

Section: -Hydroxycholecaliferol Parathyroid Hormone Serum Lipids Elmentioning

confidence: 99%

Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status

Jungert

Roth²,

Neuhäuser‐Berthold

2014

Public Health Nutr.

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Objective: Although emerging evidence indicates an association between vitamin D and serum lipids, the data are still inconsistent. The purpose of the present study was to investigate whether 25-hydroxycholecalciferol (25-hydroxyvitamin D 3 ; 25(OH)D 3 ) or intact parathyroid hormone (iPTH) was independently related to serum lipids in elderly women and men. Design: Cross-sectional study. Fasting serum levels of 25(OH)D 3 , iPTH, TAG, total cholesterol (TC), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) were assessed. Body composition was measured by bioelectrical impedance analysis. Lifestyle factors, such as nutrient intake, time spent outdoors, physical activity, smoking, supplement intake and medication, were assessed by questionnaires. Multiple regression analyses were performed to examine associations of 25(OH)D 3 and iPTH with serum lipids. Setting: Giessen, Germany. 25-Hydroxycholecaliferol Parathyroid hormone Serum lipids ElderlyAccumulating epidemiological data indicate that vitamin D deficiency may be accompanied by susceptibility for chronic diseases (1) . Recently, a low vitamin D status has been linked to increased serum levels of TAG, total cholesterol (TC) and LDL cholesterol (LDL-C), as well as low concentrations of HDL cholesterol (HDL-C) (2)(3)(4)(5)(6)(7)(8) . Parathyroid hormone (PTH), which increases in the presence of vitamin D insufficiency, was also linked to serum lipids (9) . However, the results are inconsistent and associations often vanished after controlling for confounding variables (5,6,8) .The question arises whether the assumed associations between serum lipids and vitamin D and PTH are independent from other cardiovascular risk factors like obesity, which has been associated with elevated serum lipids (10) and may also interfere with the vitamin D endocrine system (11) . In addition, the associations may differ by sex considering the differences in body composition and serum lipid levels between women and men. Previous studies were mostly performed on ambulatory patients and/or vitamin Ddeficient, middle-aged or overweight and obese individuals and often without adjustments for potential confounders, such as the association between vitamin D and PTH, body composition, medical conditions and/or lifestyle factors, including sun exposure, physical activity and habitual diet (4)(5)(6)(7)9,(12)(13)(14)(15) .As dyslipidaemia is an important CVD risk factor and an established component of the metabolic syndrome, treatment and prevention strategies are of particular importance (16) . This applies especially to elderly people, who are at risk of developing dyslipidaemia. Moreover, an advanced age is linked to vitamin D deficiency because of age-related declines in endogenous vitamin D synthesis, sun exposure

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Section: -Hydroxycholecaliferol Parathyroid Hormone Serum Lipids Elmentioning

confidence: 99%

Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status

Jungert

Roth²,

Neuhäuser‐Berthold

2014

Public Health Nutr.

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“…This link could be mediated by IR; alternatively, it is possible that vitamin D directly affects lipid metabolism by interfering with the activity of different enzymes, as suggested by some observations in vitro [7]. To date, a direct effect of vitamin D deficiency on atherogenic dyslipidemia is still debated, being supported by some studies [8,9], but only modestly confirmed by other authors [10].…”

Section: Introductionmentioning

confidence: 77%

Lipid Accumulation Product and 25-OH-Vitamin D Deficiency in Type 2 Diabetes

et al. 2013

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■ Abstract BACKGROUND:Emerging data suggest a link between vitamin D (25(OH)D) deficiency, type 2 diabetes (T2D), and visceral adiposity. The lipid accumulation product (LAP), strictly correlated with abdominal fat depots, is proposed as marker of dysfunctional adiposity. AIM: To verify the association between 25(OH)D levels and LAP in T2D. METH-ODS: Body mass index (BMI), waist circumference (WC), glucose, HbA1c, lipids, and 25(OH)D were assessed in 420 T2D outpatients and in 150 non-diabetic obese with similar anthropometric characteristics. LAP was computed as the product of sex-specific enlarged WC and triglycerides (TG). RESULTS: In T2D patients, 63.0% showed 25(OH)D deficiency (<20 ng/ml) vs. 71.3% in the obese control group. Overweight males showed a higher prevalence of 25(OH)D deficiency (60.3%) than women (48.8%, p < 0.001), while in obese patients this prevalence was not significant. In both genders, 25(OH)D was not significantly associated with HbA1c and fasting glucose. Age-adjusted 25(OH)D levels were inversely correlated with BMI (p < 0.001), WC (p < 0.001), and LAP (p < 0.001) in both genders. Metabolic syndrome presented an odds ratio (OR) for 25(OH)D deficiency of 1.6 (1.1-2.5, p = 0.048) in females and 1.7 (1.2-2.7, p = 0.016) in males, while the highest quartile of LAP showed an OR of 2.1 (1.2-3.6, p = 0.019) in females and 3.2 (1.6-6.5, p = 0.02) in males. A similar trend was observed in the obese control group. CONCLUSIONS: In the presence of excess weight, subjects with and without T2D frequently feature low 25(OH)D levels. Subjects with higher LAP exhibit a high risk of 25(OH)D deficiency, suggesting that dysfunctional adiposity is a worsening factor for vitamin D hypovitaminosis.

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“…In a study, Karhapaa et at. 17 found low level of 25-hydroxycholecalciferol associated with high levels of TC, LDL-C and triglycerides. In another study, Auwerx, Bouillon and Kesteloot, 18 a positive correlation of 25-Hydroxycholecalciferol with HDL-C levels was observed.…”

Section: Resultsmentioning

confidence: 99%

Association of 25-OH Cholecalciferol with Acute Myocardial Infarction

Islam¹,

Majumder

Debnath³

et al. 2017

Bangladesh J Med Biochem

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Cholesterol and LDL-Cholesterol were found significantly higher in AMI compared to those among healthy controls. Among all study subjects, statistically significant positive correlation of 25(OH)D 3 was found with HDL-C (p=0.014). Significant negative correlation was found with serum TC (p=0.001) and LDL-C (p <0.001). Serum TG was found negatively correlated with 25-hydroxycholecalciferol but it was not statitiscaly significant (p=0.068). In our study Vitamin-D deficiency was found to be significantly associated with myocardial infarction, dyslipidemia and hypertension.

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Diverse associations of 25‐hydroxyvitamin D and 1,25‐dihydroxy‐vitamin D with dyslipidaemias

Cited by 120 publications

References 32 publications

Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status

Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status

Lipid Accumulation Product and 25-OH-Vitamin D Deficiency in Type 2 Diabetes

Association of 25-OH Cholecalciferol with Acute Myocardial Infarction

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