Diverse biological effects of the essential oil from Iranian Trachyspermum ammi

Vitali, Luca A.; Beghelli, Daniela; Nya, Prosper Cabral Biapa; Bistoni, Onelia; Cappellacci, Loredana; Damiano, Silvia; Lupidi, Giulio; Maggi, Filippo; Orsomando, Giuseppe; Papa, Fabrizio; Petrelli, Dezemona; Petrelli, Riccardo; Quassinti, Luana; Sorci, Leonardo; Zadeh, Majid Majd; Bramucci, Massimo

doi:10.1016/j.arabjc.2015.06.002

Cited by 104 publications

(74 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our effort to explore natural compounds against nicotinate mononucleotide adenylyltransferase of the NadD family [26,27], an essential enzyme of NAD biosynthesis in most bacteria, we evaluated the in vitro inhibition of E. floribundus essential oil against NadD from S. aureus. A preliminary single point inhibition test at the concentration of 80 µg/mL indicated a~60% inhibition with no effect on the ubiquitous mammalian isoform NMNAT1 [28].…”

Section: Nadd Inhibition Analysismentioning

confidence: 99%

See 1 more Smart Citation

Biological Activities of the Essential Oil from Erigeron floribundus

et al. 2016

Self Cite

View full text Add to dashboard Cite

Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In the present study, we evaluated the in vitro biological activities displayed by the essential oil obtained from the aerial parts of E. floribundus, namely the antioxidant, antimicrobial and antiproliferative activities. Moreover, we investigated the inhibitory effects of E. floribundus essential oil on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for developing novel antibiotics, and Trypanosoma brucei, the protozoan parasite responsible for Human African trypanosomiasis. The essential oil composition was dominated by spathulenol (12.2%), caryophyllene oxide (12.4%) and limonene (8.8%). The E. floribundus oil showed a good activity against Staphylococcus aureus (inhibition zone diameter, IZD of 14 mm, minimum inhibitory concentration, MIC of 512 µg/mL). Interestingly, it inhibited the NadD enzyme from S. aureus (IC 50 of 98 µg/mL), with no effects on mammalian orthologue enzymes. In addition, T. brucei proliferation was inhibited with IC 50 values of 33.5 µg/mL with the essential oil and 5.6 µg/mL with the active component limonene. The essential oil exhibited strong cytotoxicity on HCT 116 colon carcinoma cells with an IC 50 value of 14.89 µg/mL, and remarkable ferric reducing antioxidant power (tocopherol-equivalent antioxidant capacity, TEAC = 411.9 µmol·TE/g).

show abstract

Section: Nadd Inhibition Analysismentioning

confidence: 99%

“…The enzyme inhibition assay setup for the bacterial enzyme and the mammalian counter target is described in detail in Vitali et al [27]. Briefly, enzyme rates and inhibition were measured by an established endpoint assay based on the detection at 620 nm of the phosphate byproduct formed [17].…”

Section: Enzyme Inhibition Assaymentioning

confidence: 99%

Biological Activities of the Essential Oil from Erigeron floribundus

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…These pathogenic bacteria can act as putrefactive agents in meat. Vitali et al 23 reported that T. ammi essential oil inhibited from the proliferation of the Gram-positive bacteria and especially S. aureus. Among Gram-negative bacteria, only E. coli was susceptible to T. ammi essential oil.…”

Section: Discussionmentioning

confidence: 99%

Study the antimicrobial effects of chitosan-based edible film containing the Trachyspermum ammi essential oil on shelf-life of chicken meat

Karimnezhad

Razavilar

Anvar

et al. 2017

Microbiol Res (Pavia)

View full text Add to dashboard Cite

Packaging using chitosan-based edible films incorporated with natural essential oils is a safe and economic way to increase the shelf-life and acceptability of food products and especially chicken meat. Trachyspermum ammi is a natural medicinal plant with high antimicrobial effects cultivated in Iran. The present research was done to study the antimicrobial effects of chitosan-based edible film containing T. ammi essential oil on shelf-life of chicken meat. T. ammi fruits were collected and dried. Essential oil was extracted from plants using the Clevenger's apparatus. High molecular weight chitosan with 1% and 2% concentrations of T. ammi essential oil were used for coating of chicken fillets. Treatments were stored at 4°C for 12 days.

show abstract

“…In our effort to explore natural compounds against nicotinate mononucleotide adenylyltransferase of the NadD family [24,25], an essential enzyme of NAD biosynthesis in most bacteria, we evaluated the in vitro inhibition of E. floribundus essential oil against NadD from S. aureus. A preliminary single point inhibition test at the concentration of 80 μg/mL indicated a ~ 60% inhibition with no effect on the ubiquitous mammalian isoform NMNAT1 [26].…”

Section: Nadd Inhibition Analysismentioning

confidence: 99%

Biological Activities of the Essential Oil from <em>Erigeron floribundus</em>

Petrelli¹,

Orsomando

Sorci

et al. 2016

Preprint

Self Cite

View full text Add to dashboard Cite

Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in the Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In the present study we evaluated the in vitro biological activities displayed by the essential oil obtained from the aerial parts of E. floribundus, namely the antioxidant, antimicrobial and antiproliferative activities. Moreover, we investigated the inhibitory effects of E. floribundus essential oil on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for developing novel antibiotics, and Trypanosoma brucei, the protozoan parasite responsible for Human African trypanosomiasis. The essential oil composition was dominated by spathulenol (12.2%), caryophyllene oxide (12.4%) and limonene (8.8%). The E. floribundus oil showed a good activity against Staphylococcus aureus (IZD of 14 mm, MIC of 512 µg/mL). Interestingly, it inhibited the NadD enzyme from S. aureus (IC50 of 98 µg/mL), with no effects on mammalian orthologue enzymes. In addition, T. brucei proliferation was inhibited with IC50 values of 33.5 µg/mL with the essential oil and 5.6 µg/mL with the active component limonene. The essential oil exhibited strong cytotoxicity on HCT 116 colon carcinoma cells with an IC50 value of 14.89 µg/mL, and remarkable ferric reducing antioxidant power (TEAC= 411.9 μmol TE/g).

show abstract

Diverse biological effects of the essential oil from Iranian Trachyspermum ammi

Cited by 104 publications

References 41 publications

Biological Activities of the Essential Oil from Erigeron floribundus

Biological Activities of the Essential Oil from Erigeron floribundus

Study the antimicrobial effects of chitosan-based edible film containing the Trachyspermum ammi essential oil on shelf-life of chicken meat

Biological Activities of the Essential Oil from <em>Erigeron floribundus</em>

Contact Info

Product

Resources

About