Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation

Ess, Kevin C.; Witte, David P.; Bascomb, Charles P; Aronow, Bruce J.

doi:10.1038/sj.onc.1202387

Cited by 58 publications

(57 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aside from the haemopoietic system, there is a growing list of vertebrate tissues which express c-Myb at some stage in their development; this now includes the developing ear, the neuroretina, the lung epithelium, the colon, aortic smooth muscle cells, the thyroid and hair follicles (Thompson and Ramsay, 1995;Ess et al, 1999). Indeed, both of the viral forms of c-Myb have been shown to be capable of inducing bFGFdependent proliferation of chick neuroretinal cells (Amouyel et al, 1989;Garrido et al, 1992a) and of cooperating with v-Myc to elicit neuroretinal cell transformation (Garrido et al, 1992b).…”

Section: Introductionmentioning

confidence: 99%

v-Myb can transform and regulate the differentiation of melanocyte precursors

Bell

Frampton

1999

Oncogene

View full text Add to dashboard Cite

The activity of the c-Myb transcription factor is essential for the development of de®nitive multi-and uni-lineage progenitors of the haemopoietic system. Re¯ecting this requirement, c-Myb has been oncogenically activated by transduction in the E26 avian retrovirus which elicits an acute leukaemia by transforming haemopoietic progenitors. Here, we report the novel ®nding that Myb in cooperation with EGF receptor signalling can be used to generate clonally expanded populations of transformed cells which have the phenotype of melanocyte precursors. Through the use of a conditional temperature sensitive mutant of Myb, we show that in the transformed cells Myb regulates commitment to melanocyte di erentiation and possibly proliferation. These results add to our understanding of the roles of c-Myb beyond the haemopoietic system and to our knowledge and means of investigating the importance of transcription factors in the melanocyte linage.

show abstract

Section: Introductionmentioning

confidence: 99%

v-Myb can transform and regulate the differentiation of melanocyte precursors

Bell

Frampton

1999

Oncogene

View full text Add to dashboard Cite

show abstract

“…[127][128][129][130] Consistent with its expression pattern, c-Myb knockout mice lack all hematopoietic lineages except the megakaryocytic branch. 131 In addition, ectopic expression of c-Myb in 32D cl3 cells allowed G-CSF induction of early differentiation markers, such as MPO.…”

Section: C-mybmentioning

confidence: 81%

Regulation of granulopoiesis by transcription factors and cytokine signals

et al. 2000

View full text Add to dashboard Cite

“…Mice lacking a functional c-myb gene die during embryonic development because of defects in fetal hepatic hematopoiesis (Mucenski et al, 1991). c-myb is also expressed in certain nonhematopoietic cells and tissues (Desbiens et al, 1991;Queva et al, 1992;Plaza et al, 1995;Sitzmann et al, 1995;Rosenthal et al, 1996, Ess et al, 1999. Although it has been suggested that the role of c-myb in these cells is to prevent them from undergoing terminal di erentiation, the function of c-myb in non-hematopoietic cells is not well understood at present.…”

Section: Introductionmentioning

confidence: 99%