Diverse Forms of Guanylyl Cyclases in Medaka Fish – Their Genomic Structure and Phylogenetic Relationships to those in Vertebrates and Invertebrates

Yamagami, Shigemasa; Suzuki, Norio

doi:10.2108/zsj.22.819

Cited by 21 publications

(5 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A third membrane-bound GC was discovered in rat olfactory sensory neurons and was, unfortunately, named D, and the rodent orthologue of human GUCYD is called GUCY2E. The proposed human orthologue of rodent GC-D is called GC-E (Yamagami & Suzuki 2005). Further confusion arises because the third form in chicken has been named F. These non-receptor mGCs function as homodimers (Sharma 2002).…”

Section: H Sapiens Gnb1mentioning

confidence: 99%

Evolution of vertebrate rod and cone phototransduction genes

Larhammar

Nordström

Larsson

2009

Phil. Trans. R. Soc. B

115

View full text Add to dashboard Cite

Vertebrate cones and rods in several cases use separate but related components for their signal transduction (opsins, G-proteins, ion channels, etc.). Some of these proteins are also used differentially in other cell types in the retina. Because cones, rods and other retinal cell types originated in early vertebrate evolution, it is of interest to see if their specific genes arose in the extensive gene duplications that took place in the ancestor of the jawed vertebrates (gnathostomes) by two tetraploidizations (genome doublings). The ancestor of teleost fishes subsequently underwent a third tetraploidization. Our previously reported analyses showed that several gene families in the vertebrate visual phototransduction cascade received new members in the basal tetraploidizations. We here expand these data with studies of additional gene families and vertebrate species. We conclude that no less than 10 of the 13 studied phototransduction gene families received additional members in the two basal vertebrate tetraploidizations. Also the remaining three families seem to have undergone duplications during the same time period but it is unclear if this happened as a result of the tetraploidizations. The implications of the many early vertebrate gene duplications for functional specialization of specific retinal cell types, particularly cones and rods, are discussed.

show abstract

Section: H Sapiens Gnb1mentioning

confidence: 99%

Evolution of vertebrate rod and cone phototransduction genes

Larhammar

Nordström

Larsson

2009

Phil. Trans. R. Soc. B

115

View full text Add to dashboard Cite

show abstract

“…Similar to heterozygous NOTCH1 mutations in human (Garg et al, 2005), homozygous eNOS knockout mice also display bicuspid aortic valves and other major cardiac anomalies (Aicher et al, 2007;Feng et al, 2002;Lee et al, 2000). Of the three classes of type III guanylyl cyclases (GCs), NO signaling is propagated through the soluble GC (sGC) heterodimer (Baker and Kelly, 2004;Yamagami and Suzuki, 2005), which consists of an a subunit (GUCY1A2 or GUCY1A3) and a b subunit (GUCY1B3). GUCY1A3/1B3 is expressed in most tissues, whereas GUCY1A2/1B3 is predominantly found in the brain (Giuili et al, 1992;Mergia et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase

et al. 2011

View full text Add to dashboard Cite

The heart is the most common site of congenital defects, and valvuloseptal defects are the most common of the cardiac anomalies seen in the newborn. The process of endothelial-to-mesenchymal transition (EndMT) in the cardiac cushions is a required step during early valve development, and Notch signaling is required for this process. Here we show that Notch activation induces the transcription of both subunits of the soluble guanylyl cyclase (sGC) heterodimer, GUCY1A3 and GUCY1B3, which form the nitric oxide receptor. In parallel, Notch also promotes nitric oxide (NO) production by inducing Activin A, thereby activating a PI3-kinase/Akt pathway to phosphorylate eNOS. We thus show that the activation of sGC by NO through a Notch-dependent autocrine loop is necessary to drive early EndMT in the developing atrioventricular canal (AVC).

show abstract

“…A publication cataloging all human kinases briefly mentions that human GC-D is a pseudogene [27]; we confirm this finding, showing that human GC-D contains multiple inactivating sequence changes. It should be noted that the human gene whose officially approved name is GUCY2D (Genbank NM_000180) is not the ortholog of mouse Gucy2d (GC-D) but instead is the ortholog of the rodent retina-specific Gucy2e gene [28](see also MGD www.informatics.jax.org), and is not the gene we discuss here.…”

Section: Resultsmentioning

confidence: 99%

Degeneration of the Olfactory Guanylyl Cyclase D Gene during Primate Evolution

et al. 2007

View full text Add to dashboard Cite

BackgroundThe mammalian olfactory system consists of several subsystems that detect specific sets of chemical cues and underlie a variety of behavioral responses. Within the main olfactory epithelium at least three distinct types of chemosensory neurons can be defined by their expression of unique sets of signal transduction components. In rodents, one set of neurons expresses the olfactory-specific guanylyl cyclase (GC)-D gene (Gucy2d, guanylyl cyclase 2d) and other cell-type specific molecules. GC-D-positive neurons project their axons to a small group of atypical “necklace” glomeruli in the olfactory bulb, some of which are activated in response to suckling in neonatal rodents and to atmospheric CO2 in adult mice. Because GC-D is a pseudogene in humans, signaling through this system appears to have been lost at some point in primate evolution.Principal FindingsHere we used a combination of bioinformatic analysis of trace-archive and genome-assembly data and sequencing of PCR-amplified genomic DNA to determine when during primate evolution the functional gene was lost. Our analysis reveals that GC-D is a pseudogene in a large number of primate species, including apes, Old World and New World monkeys and tarsier. In contrast, the gene appears intact and has evolved under purifying selection in mouse, rat, dog, lemur and bushbaby.ConclusionsThese data suggest that signaling through GC-D-expressing cells was probably compromised more than 40 million years ago, prior to the divergence of New World monkeys from Old World monkeys and apes, and thus cannot be involved in chemosensation in most primates.

show abstract

Diverse Forms of Guanylyl Cyclases in Medaka Fish – Their Genomic Structure and Phylogenetic Relationships to those in Vertebrates and Invertebrates

Cited by 21 publications

References 88 publications

Evolution of vertebrate rod and cone phototransduction genes

Evolution of vertebrate rod and cone phototransduction genes

Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase

Degeneration of the Olfactory Guanylyl Cyclase D Gene during Primate Evolution

Contact Info

Product

Resources

About