Diverse polyacetylenes from Atractylodes chinensis and their anti-osteoclastogenesis activity

Zhang, Yuting; Peng, Xing; Sun, Zhejun; Chen, Hu; Zhou, Huihao; Xu, Jun; Gu, Qiong

doi:10.1016/j.fitote.2022.105233

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2024

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Cited by 7 publications

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“…is a perennial herb of Atractylodes , a natural medicinal material in northeast China. A. chinensis is rich in sesquiterpenes and polyethylenes, and so on [1–3] . Sesquiterpenoids have been confirmed to possess rich biological activity, including cytotoxicity, [4–6] neuroprotective activity, [7] anti‐inflammatory, and so on [8] .…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Sesquiterpenoids from Atractylodes chinensis (DC.) Koidz.

Zhuang

Liu

Wang

et al. 2022

Chemistry & Biodiversity

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Four new sesquiterpenoids named atrchiterpenes A–D (1–4), a new natural product (5), and twelve known compounds (6–17) were isolated from Atractylodes chinensis (DC.) Koidz. Compound 1 was a rare N‐containing eudesmane‐type sesquiterpenoid. Structure elucidation was performed by spectroscopic techniques, including 1D, 2D NMR spectra, and HR‐ESI‐MS. Compounds 6–11, 14, and 17 were reported from Atractylodes for the first time. All the isolated compounds were evaluated for cytotoxicity activity. Compound 16 showed moderate cytotoxicity against HepG2 cells with an IC50 value of 5.81±0.47.

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