Diverse synthesis of medicinally active steroids

Borah, Preetismita; Banik, Bimal K.

doi:10.1016/b978-0-12-817592-7.00012-5

Cited by 7 publications

(2 citation statements)

References 94 publications

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“…In general, the steroid core structure has 17 carbon atoms connected with 4 fused rings in a specific way. Three of these are cyclohexanes (A, B, and C) and one is cyclopentane system (D ring) (Borah and Banik, 2020). Talasterone A (174) (Figure 11), an unprecedented 6/6/5 tricyclic 13 (14 → 8) abeo-8,14-secoergostane steroid, was characterized from T. adpressus isolated from soil collected from Yalong Bay in Sanya, Hainan (Zhang et al, 2022a).…”

Section: Steroidsmentioning

confidence: 99%

Research advances in the structures and biological activities of secondary metabolites from Talaromyces

et al. 2022

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The genus Talaromyces belongs to the phylum Ascomycota of the kingdom Fungi. Studies have shown that Talaromyces species yield many kinds of secondary metabolites, including esters, terpenes, steroids, alkaloids, polyketides, and anthraquinones, some of which have biological activities such as anti-inflammatory, bacteriostatic, and antitumor activities. The chemical constituents of fungi belonging to the genus Talaromyces that have been studied by researchers over the past several years, as well as their biological activities, are reviewed here to provide a reference for the development of high-value natural products and innovative uses of these resources.

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Section: Steroidsmentioning

confidence: 99%

Research advances in the structures and biological activities of secondary metabolites from Talaromyces

et al. 2022

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“…[29,30] A significant portion of current drugs used to treat various conditions is based on either naturally occurring or semisynthetic steroidal molecules. [31] Numerous privileged structures based on the steroid scaffold are recognized, in which even simple modifications can lead to drastic alterations of their biological effect. [32] Quite a few steroids can act as anticancer agents, with modes of action that involve enzymes, receptors, or other non-hormonal mechanisms; [33,34] some of such compounds were prepared by our group.…”

Section: Introductionmentioning

confidence: 99%

Toward Selective Anticancer Agents: Ferrocene‐Steroid Conjugates

Raičević

Radulović²,

Sakač

2022

Eur J Inorg Chem

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The medicinal chemistry of ferrocene is a diverse and rapidly growing field. In the search for selective and more efficient anticancer drugs, ferrocene‐steroid conjugates were explored in the past as a tool to target hormone‐dependent cancer cells, notably those of breast and prostate cancers. The mechanisms by which ferrocene compounds induce cytotoxicity are first examined, as well as how they can be exploited to design conjugates of ferrocene with steroid hormones potentially acting as selective antineoplastics. We sought to cover all relevant literature related to ferrocene‐steroid conjugates, from early works published in the 1970s up to now. Particular attention was bestowed upon research where the conjugates were tested for their antitumor potential.

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