The Neotropical xyleborine ambrosia beetle genus Coptoborus Hopkins is reviewed. The following 40 Coptoborus species are described: C. amplissimussp. nov. (Peru), C. asperatussp. nov. (Ecuador), C. barbicaudasp. nov. (French Guiana), C. bettysmithaesp. nov. (Ecuador), C. brevicaudasp. nov. (Ecuador), C. brigmansp. nov. (Ecuador), C. busororsp. nov. (Ecuador), C. capillisororsp. nov. (Brazil), C. chicasp. nov. (Suriname), C. crassisororculasp. nov. (Peru), C. doliolumsp. nov. (Ecuador), C. erwinisp. nov. (Ecuador), C. furiosasp. nov. (Ecuador), C. galacatosaesp. nov. (Ecuador), C. hansensp. nov. (Brazil), C. incomptussp. nov. (Peru), C. janewaysp. nov. (Peru), C. katnisssp. nov. (Ecuador), C. leeloosp. nov. (Ecuador), C. leiasp. nov. (Ecuador, Suriname), C. leporinussp. nov. (Peru), C. martinezaesp. nov. (Ecuador), C. murinussp. nov. (Ecuador), C. newtsp. nov. (Peru), C. osbornaesp. nov. (Ecuador), C. panosussp. nov. (French Guiana), C. papillicaudasp. nov. (Suriname), C. pilisororsp. nov. (Ecuador), C. ripleysp. nov. (Ecuador), C. sagitticaudasp. nov. (Guyana), C. sarahconnorsp. nov. (Brazil), C. scullysp. nov. (Ecuador), C. siculasp. nov. (Ecuador), C. sororculasp. nov. (Peru), C. starbucksp. nov. (Ecuador), C. trinitysp. nov. (Brazil), C. uhurasp. nov. (Peru), C. vasquezsp. nov. (Panama), C. vrataskisp. nov. (Brazil), and C. yarsp. nov. (Ecuador). Seventeen new combinations are given: Coptoborus amazonicus (Petrov, 2020) comb. nov., C. atlanticus (Bright & Torres, 2006) comb. nov., C. bellus Bright & Torres, 2006 comb. nov., C. coartatus (Sampson, 1921) comb. nov., C. crinitulus (Wood, 1974) comb. nov., C. exilis (Schedl, 1934) comb. nov., C. incultus (Wood, 1975) comb. nov., C. magnus (Petrov, 2020) comb. nov., C. micarius (Wood, 1974) comb. nov., C. obtusicornis (Schedl, 1976) comb. nov., C. paurus (Wood, 2007) comb. nov., C. pristis (Wood, 1974) comb. nov., C. pseudotenuis (Schedl, 1936) comb. nov., C. puertoricensis (Bright & Torres, 2006) comb. nov., C. ricini (Eggers, 1932) comb. nov., C. semicostatus (Schedl, 1948) comb. nov., C. tristiculus (Wood, 1975) comb. nov., and C. villosulus (Blandford, 1898) comb. nov. Two new synonyms are proposed: Coptoborus Hopkins, 1915 (= Theoborus Hopkins, 1915 syn. nov.) and Coptoborus villosulus (Blandford, 1898) (= Theoborus theobromae Hopkins, 1915 syn. nov.). Xyleborus neosphenos Schedl, 1976 comb. res. is removed from Coptoborus. The revised genus now contains 77 species and a key to their identification is provided.