Diversification and deleterious role of microbiome in gastric cancer

Chattopadhyay, Indranil; Gundamaraju, Rohit; Rajeev, Ashwin

doi:10.1002/cnr2.1878

Cited by 9 publications

(3 citation statements)

References 119 publications

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“…After the eradication of the bacterium by antibiotic therapy, the restoration of bacterial abundance similar to that of patients who never contracted the infection can be achieved, showing how the bacterium-induced condition is reversible [88]. Today we know that the gastric microbiota, in addition to Hp, comprises about 10 3 -10 4 CFU [90]. The most frequent bacterial phyla in the healthy stomach are Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria and Fusobacteria; additionally, the most frequent genera are Helicobacter, Streptococcus and Prevotella.…”

Section: Aag and Hypochlorhydria: What Are The Consequences On The Ga...mentioning

confidence: 99%

Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

Vavallo,

Cingolani,

Cozza

et al. 2024

IJMS

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Autoimmune atrophic gastritis is an immune-mediated disease resulting in autoimmune destruction of the specialized acid-producing gastric parietal cells. As a consequence, in autoimmune atrophic gastritis, gastric acid secretion is irreversibly impaired, and the resulting hypochlorhydria leads to the main clinical manifestations and is linked, directly or indirectly, to the long-term neoplastic complications of this disease. In the last few years, autoimmune atrophic gastritis has gained growing interest leading to the acquisition of new knowledge on different aspects of this disorder. Although reliable serological biomarkers are available and gastrointestinal endoscopy techniques have substantially evolved, the diagnosis of autoimmune atrophic gastritis is still affected by a considerable delay and relies on histopathological assessment of gastric biopsies. One of the reasons for the diagnostic delay is that the clinical presentations of autoimmune atrophic gastritis giving rise to clinical suspicion are very different, ranging from hematological to neurological–psychiatric up to gastrointestinal and less commonly to gynecological–obstetric symptoms or signs. Therefore, patients with autoimmune atrophic gastritis often seek advice from physicians of other medical specialties than gastroenterologists, thus underlining the need for increased awareness of this disease in a broad medical and scientific community.

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Section: Aag and Hypochlorhydria: What Are The Consequences On The Ga...mentioning

confidence: 99%

Autoimmune Gastritis and Hypochlorhydria: Known Concepts from a New Perspective

Vavallo,

Cingolani,

Cozza

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…The human microbiota, encompassing viruses, fungi, and bacteria, can undergo dysbiosis due to diets, antibiotics, microbial infections, and host genetics ( Meng et al, 2018 ; Chattopadhyay et al, 2023 ). A balanced microbiota plays a protective role against cancer development, whereas dysbiosis may promote oncogenesis ( Garrett, 2015 ; Meng et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Association between gut microbiota and gastric cancers: a two-sample Mendelian randomization study

Chang,

Gao,

Feng

2024

Front. Microbiol.

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BackgroundGastric cancer (GC) is the fifth most commonly diagnosed cancer worldwide, with its etiology attributed to a complex interplay of genetic, dietary, environmental factors, and infections such as Helicobacter pylori. Despite the known risk factors, the role of gut microbiota in the development of gastric cancer remains insufficiently explored. This study aims to elucidate the causal relationship between gut microbiota and gastric cancer using a two-sample Mendelian Randomization (MR) approach.MethodsUtilizing genome-wide association study (GWAS) summary data from the MiBioGen consortium and gastric cancer datasets, we selected instrumental variables for MR analysis based on their association with specific microbiota. We employed several MR methods, including inverse variance weighted (IVW), MR-Egger, weighted median, and others, to estimate the causal effects of gut microbiota diversity on the risk of developing gastric cancer.ResultsOur analysis identified significant associations between certain gut microbiota and gastric cancer risk. Specifically, taxa such as Clostridium sensustricto1 (OR = 0.540, 95%CI: 0.354–0.823, p = 0.004), Actinomycetales (OR = 0.756, 95%CI: 0.613–0.932, p = 0.009), Selenomonadales (OR = 0.816, 95%CI: 0.666–1.000, p < 0.05), Negativicutes (OR = 0.816, 95%CI: 0.666–1.000, p < 0.05), Rikenellaceae (OR = 0.863, 95%CI: 0.746–0.999, p = 0.048) were found to have a protective effect against gastric cancer. Conversely, an increased risk of gastric cancer was associated with the abundance of Roseburia (OR = 1.342, 95%CI: 1.071–1.681, p = 0.011), Family XI (OR = 1.132, 95%CI: 1.012–1.267, p = 0.030), and Eubacterium brachy group (OR = 1.207, 95%CI: 1.074–1.355, p = 0.002). The findings were robust across various MR methods and were not driven by any single SNP, indicating a genuine causal relationship.ConclusionOur studies have shown that there is a causal relationship between intestinal flora and gastric cancer at the genetic level. Clostridium sensustricto1, Actinomycetales, Rikenellaceae, Selenomonadales, Negativicutes, and Actinomycetaceae as having a protective role against GC, while Roseburia, Family XI, and Eubacterium brachy group were associated with an increased risk.

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“…Thus, these studies highlight the necessity to thoroughly evaluate the influence of refined dietary fibers that are claimed to have health‐promoting effects. Further, a group led by Dr. Indranil Chattopadhyay reviewed the landscape of gut microbes associated with gastric cancer 3 . They have elaborated on the roles of virulence factors secreted by several bacteria, such as Escherichia coli, Lactobacillus , Streptococcus , and so on, in addition to Helicobacter pylori , which lead to inflammation and development of gastric cancer.…”

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confidence: 99%