Diversity and phylogenetic relationships among the North American Tacaribe serocomplex viruses (Family Arenaviridae)

Cajimat, Maria N.B.; Milazzo, Mary Louise; Haynie, Michelle L.; Hanson, John D.; Bradley, Robert D.; Fulhorst, Charles F.

doi:10.1016/j.virol.2011.09.013

Cited by 11 publications

(22 citation statements)

References 39 publications

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“…Cells overexpressing the indicated TfR1 were then infected with murine leukemia viruses pseudotyped with GPC proteins of clade A/B arenaviruses; for this study, we selected six viruses that are widely distributed in a phylogenetic tree based only on GPC sequences of clade A/B viruses ( Fig. 1B and Table 1) (14). They are WWAV and BBTV isolated from white-throated wood rats (Neotoma albigula) in New Mexico in 1993 and in Arizona, respectively (15,20); AV96010151 and SKTV isolated from Mexican wood rats (Neotoma mexicana) in New Mexico and in Arizona, respectively (22,37); BCNV isolated from California mice (Peromyscus californi- (18,19).…”

Section: Resultsmentioning

confidence: 99%

“…These synthesized GPC genes were cloned into the pCAGGS expression vector. (14). The sequences used in these analyses are described in Materials and Methods.…”

Section: Methodsmentioning

confidence: 99%

“…While clades A, B, and C arenaviruses are restricted to South America, clade A/B viruses are found only in North America (14)(15)(16)(17). These viruses are most closely related to clade B in their entry glycoproteins (GPC) (5), whereas their nucleoproteins (NP) are more closely related to those of clade A viruses.…”

Section: Importancementioning

confidence: 99%

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Human and Host Species Transferrin Receptor 1 Use by North American Arenaviruses

Zong

Fofana

Choe

2014

J Virol

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At least five New World (NW) arenaviruses cause hemorrhagic fevers in South America. These pathogenic clade B viruses, as well as nonpathogenic arenaviruses of the same clade, use transferrin receptor 1 (TfR1) of their host species to enter cells. Pathogenic viruses are distinguished from closely related nonpathogenic ones by their additional ability to utilize human TfR1 (hTfR1). Here, we investigate the receptor usage of North American arenaviruses, whose entry proteins share greatest similarity with those of the clade B viruses. We show that all six North American arenaviruses investigated utilize host species TfR1 orthologs and present evidence consistent with arenavirus-mediated selection pressure on the TfR1 of the North American arenavirus host species. Notably, one of these viruses, AV96010151, closely related to the prototype Whitewater Arroyo virus (WWAV), entered cells using hTfR1, consistent with a role for a WWAV-like virus in three fatal human infections whose causative agent has not been identified. In addition, modest changes were sufficient to convert hTfR1 into a functional receptor for most of these viruses, suggesting that a minor alteration in virus entry protein may allow these viruses to use hTfR1. Our data establish TfR1 as a cellular receptor for North American arenaviruses, highlight an "arms race" between these viruses and their host species, support the association of North American arenavirus with fatal human infections, and suggest that these viruses have a higher potential to emerge and cause human diseases than has previously been appreciated. IMPORTANCEhTfR1 use is a key determinant for a NW arenavirus to cause hemorrhagic fevers in humans. All known pathogenic NW arenaviruses are transmitted in South America by their host rodents. North American arenaviruses are generally considered nonpathogenic, but some of these viruses have been tentatively implicated in human fatalities. We show that these North American arenaviruses use the TfR1 orthologs of their rodent host species and identify TfR1 polymorphisms suggesting an ongoing "arms race" between these viruses and their hosts. We also show that a close relative of a North American arenavirus suggested to have caused human fatalities, the Whitewater Arroyo species complex virus AV96010151, uses human TfR1. Moreover, we present data that imply that modest changes in other North American arenaviruses might allow these viruses to infect humans. Collectively, our data suggest that North American arenaviruses have a higher potential to cause human disease than previously assumed.

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Section: Resultsmentioning

confidence: 99%

“…These synthesized GPC genes were cloned into the pCAGGS expression vector. (14). The sequences used in these analyses are described in Materials and Methods.…”

Section: Methodsmentioning

confidence: 99%

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Human and Host Species Transferrin Receptor 1 Use by North American Arenaviruses

Zong

Fofana

Choe

2014

J Virol

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“…Creek virus (TTCV), and Whitewater Arroyo virus (WWAV) (Cajimat et al 2011(Cajimat et al , 2012. The results of a previous study suggested that WWAV or arenaviruses that are antigenically closely related to WWAV are etiological agents of severe febrile illnesses in humans in the United States.…”

Section: T He North American Members Of the Tacaribe Serocomplex (Arementioning

confidence: 99%

“…The results of a previous study suggested that WWAV or arenaviruses that are antigenically closely related to WWAV are etiological agents of severe febrile illnesses in humans in the United States. Woodrats and other members of the Cricetidae: Neotominae (Musser and Carleton 2005) are natural hosts of Tacaribe serocomplex viruses in the western United States (Cajimat et al 2011).…”

Section: T He North American Members Of the Tacaribe Serocomplex (Arementioning

confidence: 99%

Epizootiology of Tacaribe Serocomplex Viruses (Arenaviridae) Associated with Neotomine Rodents (Cricetidae, Neotominae) in Southern California

Louise

CajimatMaria

Mauldin

et al. 2015

Vector-Borne and Zoonotic Diseases

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Lassa Fever Virus

Garry

2014

Encyclopedia of Life Sciences

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Lassa virus, a member of the Arenaviridae family, is an enveloped virus with a bisegmented, linear, single‐stranded ribonucleic acid genome. Infection with Lassa virus can result in a range of outcomes from a mild or asymptomatic infection to Lassa fever, a severe and often fatal viral haemorrhagic fever. Human infection with Lassa virus occurs through contact with the reservoir Mastomys natalensis or infected humans. There are an estimated 300 000–500 000 cases of Lassa fever in West Africa each year, with most recorded cases occurring in Sierra Leone and Nigeria. Presently, there is no licensed vaccine or immunotherapy available for preventing or treating this disease. Although the antiviral drug ribavirin can be beneficial, it must be administered at an early stage of infection to successfully alter the disease outcome, thereby limiting its utility. Key Concepts: Lassa virus, a member of the Arenaviridae family, is the aetiologic agent of Lassa fever. Infection with Lassa virus can result in a range of outcomes from a mild or asymptomatic infection to severe and often fatal viral haemorrhagic fever. Signs and symptoms of Lassa fever are highly variable, which challenges early diagnosis. Lassa virus has an enveloped virion with a bisegmented, linear, single‐stranded ribonucleic acid genome. The Lassa virus virion contains nucleoprotein NP, zinc protein Z, glycoproteins GP1 and GP2 and an unusually long and stable signal peptide SSP. Human infection with Lassa virus occurs through contact with its reservoir Mastomys natalensis or infected humans. An estimated 300 000–500 000 cases of Lassa fever occur in West Africa each year, with most recorded cases occurring in Sierra Leone and Nigeria. No licensed vaccine or immunotherapy is presently available for preventing or treating Lassa fever. The antiviral drug ribavirin can be beneficial, but must be administered early, limiting its utility.

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Diversity and phylogenetic relationships among the North American Tacaribe serocomplex viruses (Family Arenaviridae)

Cited by 11 publications

References 39 publications

Human and Host Species Transferrin Receptor 1 Use by North American Arenaviruses

Human and Host Species Transferrin Receptor 1 Use by North American Arenaviruses

Epizootiology of Tacaribe Serocomplex Viruses (Arenaviridae) Associated with Neotomine Rodents (Cricetidae, Neotominae) in Southern California

Lassa Fever Virus

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