Diversity, metabolism and cultivation of archaea in mangrove ecosystems

Zhang, Cui-Jing; Chen, Yulian; Yi-hua, Sun; Pan, Jie; Cai, Mingwei; Li, Meng

doi:10.1007/s42995-020-00081-9

Cited by 25 publications

(12 citation statements)

References 109 publications

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“…For these few Archaea, the counteraction of salinity and the intracellular environment, as well as the interaction of nonionic osmolytes with compatible solutes, together decide the mechanism employed against osmotic stress, with salinity being the key factor. Furthermore, members of Euryarchaeota are involved in metabolism related to sulfur, carbon, and nitrogen to maintain stable ecosystem functions in high-salinity lakes such as DT and XT (50)(51)(52). Candidatus Nanohaloarchaeota and Thaumarchaeota were also among the top ve dominant Archaea in this study.…”

Section: Discussionmentioning

confidence: 58%

Prokaryotic microbial diversity analysis and metabolic function prediction of salt lakes on the Qinghai-Tibet Plateau

Zhang,

Li,

Zhu

et al. 2023

Preprint

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The Dong Taijinar Salt Lake (DT) and Xi Taijinar Salt Lake (XT) have been widely studied as mineral-rich areas. However, little is known about the composition and distribution of the microbial communities in these two lakes. In this study, metagenomics sequencing was used to analyze the diversity and potential functions of the microbial communities in DT and XT. According to our report, the salinity of DT (332.18–358.30 g/L) was 10 times higher than that of XT (20.09–36.83 g/L). Interestingly, the dominant domain in DT was Archaea (96.16%), while that in XT was Bacteria (93.09%). The distribution of Bacteria in the DT revealed 33 phyla and 1717 genera. The dominant genus in DT was Marinobacillus, which was positively correlated with total phosphorus content. There were four main phyla and 153 genera identified in the Archaea of DT. The most abundant Archaea genera in DT were Natronomonas (24.61%) and Halorubrum (23.69%), which were mainly positively correlated with the Na+, Ca2+, and Cl− contents. Similarly, there were 33 phyla and 1906 genera of Bacteria in XT, and Loktanella was the dominant genus. The archaeal taxonomy in XT mainly included four phyla and 149 genera. Proteobacteria and Euryarchaeota were the most abundant bacterial and archaeal phyla in the two salt lakes. Analysis of the halophilic mechanisms of the microorganisms identified in these two salt lakes revealed that the Bacteria in XT preferred to synthesize compatible solutes, whereas the Archaea in DT preferred a "salt-in" adaptation strategy in salt-stressed environments.

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Section: Discussionmentioning

confidence: 58%

Prokaryotic microbial diversity analysis and metabolic function prediction of salt lakes on the Qinghai-Tibet Plateau

Zhang,

Li,

Zhu

et al. 2023

Preprint

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“…Archaea are becoming an important area of research interest in microbial fields, with many novel archaeal lineages discovered (Baker et al 2020 ; Spang et al 2017 ). In our tenth paper, Zhang et al ( 2021a ) summarize the diversity and metabolism of the archaeal community in mangrove ecosystems across the world and find that Bathyarchaeota, Euryarchaeota, Thaumarchaeota, Woesearchaeota, and Lokiarchaeota are the most abundant lineages with potential ecological roles in carbon, nitrogen, and sulfur cycles. In addition, the authors propose some strategies to culture the not yet-cultured archaeal lineages from mangrove ecosystems.…”

mentioning

confidence: 95%

Cultivation of uncultured marine microorganisms

Wang

Huang

et al. 2021

Mar Life Sci Technol

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“…Microbial secondary metabolites have received great attention as a potential resource of lead drugs owing to their productive biological activities and massive chemical diversity (Hai et al 2021 ; Xu et al 2022 ). Due to the special mangrove environment, including high salinity, low oxygen, nutrient limitation, and drought, mangrove-derived fungi have the biosynthetic potential to produce a variety of unique secondary metabolites (Liang et al 2019 ; Nathan et al 2020 ; Xu et al 2014 ; Zhang et al 2021 ). The genus Talaromyces (Trichocomaceae) is a sexual state of Penicillium , and has the potential to produce depsidones (Zhao et al 2015 ; Wu et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Polyketides with potential bioactivities from the mangrove-derived fungus Talaromyces sp. WHUF0362

Xue

et al. 2023

Mar Life Sci Technol

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Metabolites of microorganisms have long been considered as potential sources for drug discovery. In this study, five new depsidone derivatives, talaronins A-E (1–5) and three new xanthone derivatives, talaronins F–H (6–8), together with 16 known compounds (9–24), were isolated from the ethyl acetate extract of the mangrove-derived fungus Talaromyces species WHUF0362. The structures were elucidated by analysis of spectroscopic data and chemical methods including alkaline hydrolysis and Mosher’s method. Compounds 1 and 2 each attached a dimethyl acetal group at the aromatic ring. A putative biogenetic relationship of the isolated metabolites was presented and suggested that the depsidones and the xanthones probably had the same biosynthetic precursors such as chrysophanol or rheochrysidin. The antimicrobial activity assay indicated that compounds 5, 9, 10, and 14 showed potent activity against Helicobacter pylori with minimum inhibitory concentration (MIC) values in the range of 2.42–36.04 μmol/L. While secalonic acid D (19) demonstrated significant antimicrobial activity against four strains of H. pylori with MIC values in the range of 0.20 to 1.57 μmol/L. Furthermore, secalonic acid D (19) exhibited cytotoxicity against cancer cell lines Bel-7402 and HCT-116 with IC50 values of 0.15 and 0.19 μmol/L, respectively. The structure–activity relationship of depsidone derivatives revealed that the presence of the lactone ring and the hydroxyl at C-10 was crucial to the antimicrobial activity against H. pylori. The depsidone derivatives are promising leads to inhibit H. pylori and provide an avenue for further development of novel antibiotics.

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Diversity, metabolism and cultivation of archaea in mangrove ecosystems

Cited by 25 publications

References 109 publications

Prokaryotic microbial diversity analysis and metabolic function prediction of salt lakes on the Qinghai-Tibet Plateau

Prokaryotic microbial diversity analysis and metabolic function prediction of salt lakes on the Qinghai-Tibet Plateau

Cultivation of uncultured marine microorganisms

Polyketides with potential bioactivities from the mangrove-derived fungus Talaromyces sp. WHUF0362

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