Diversity of methacholine dose-response curves among asymptomatic non-asthmatics

Blais, Christianne M.; Davis, Beth E.; Cockcroft, Donald W.

doi:10.1016/j.rmed.2017.10.002

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2018

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“…Several previous studies have identified non-asthmatic individuals who have methacholine AHR. 1516 Almost invariably, these studies relied on the subject’s recall to determine the past history of asthma. Here, we based asthma diagnosis on prospectively obtained data as part of a newborn cohort followed up to adult life.…”

Section: Discussionmentioning

confidence: 99%

Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics

Hiranrattana

Stern

Guerra

et al. 2018

Thorax

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In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than and AHR among non-asthmatics. Why this group of sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.

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Section: Discussionmentioning

confidence: 99%