Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives

Abstract

With the emergence of high throughput screening of bioactive molecules, there is constant need for the development of new strategies for diversity-oriented synthesis. We describe here a novel one-pot multicomponent reaction for the synthesis of uracil derivatives using easily available starting materials. This new synthetic strategy provides easy access to diverse uracil derivatives in moderate to good yields.

Fragment Discovery for the Design of Nitrogen Heterocycles as Mycobacterium tuberculosis Dihydrofolate Reductase Inhibitors

“…As a part of our ongoing research, we have developed several protocols for synthesis of heterocycles like cyanouracil ( 1 ) .…”

Orthoesters: Multiple Role Players in Organic Synthesis

“…A synthetic strategy to the substituted uracils from cyanoacetamides, TEOF , primary amines, and BTC (triphosgene) was suggested by Pedgaonkar et al . This method initially produced in situ 2‐cyano‐3‐aminoacrylamides 86 upon heating.…”