No abstract

With the emergence of high throughput screening of bioactive molecules, there is constant need for the development of new strategies for diversity-oriented synthesis. We describe here a novel one-pot multicomponent reaction for the synthesis of uracil derivatives using easily available starting materials. This new synthetic strategy provides easy access to diverse uracil derivatives in moderate to good yields.

Derivatives. -The reaction tolerates a wide range of aliphatic and aromatic cyanoacetamides and anilines. Benzylamine reacts poorly or fails to react [cf. (VII)]. -(PEDGAONKAR, Y. Y.; DEGANI*, M. S.; IYER, R. P.; Mol. Diversity 15 (2011) 1, 263-267, http://dx.doi.org/10.1007/s11030-010-9266-1 ; Dep. Pharm. Sci. Technol., Inst. Chem. Technol., Univ. Mumbai, Matunga, Mumbai 400 019, India; Eng.) -Y. Steudel 33-167