Diversity oriented synthesis of benzimidazole-based biheterocyclic molecules by combinatorial approach: a critical review

Abstract

Because of the wide ranging bioactivities associated with the benzimidazole nucleus, this review highlights the advances made in the synthesis of benzimidazole-based biheterocyclic molecules by combinatorial approaches.

Design and Synthesis of Novel Imidazole Derivatives Possessing Triazole Pharmacophore with Potent Anticancer Activity, and In Silico ADMET with GSK-3β Molecular Docking Investigations

“…Consequently, we envisioned the molecular coupling of thioimidazole derivative with the 1,2,3-triazole core through a flexible spacer. The resulting molecular hybrids could deliver better interactions with biological targets by means of their synergistic effects [ 26 ].…”

Nitrogen-Enriched Porous Benzimidazole-Linked Polymeric Network for the Adsorption of La (III), Ce (III), and Nd (III)

“…Benzimidazole linked porous materials with high porosity, low skeletal density, high stability, and proton conductivity have attracted considerable attention − for diversified applications. , As a few examples, nitrogen-enriched porous polymers become robust catalyst supports for heterogeneous catalysis with excellent chemical, thermal, and mechanical stability. − Besides their use as a proton-exchange membrane in fuel cells, these polymers have been advocated for diversified applications including energy storage, gas adsorption, gas storage, drug delivery, electronics, separation processes, ,, and sensing applications . Of notice is their important role in Schiff base reactions, Sonogashira coupling reactions, nitrile trimerization, Yamamoto coupling, alkyne trimerization, and boronate ester formation …”

Synthesis, Characterization, and Antiproliferative Activity Studies of Novel Benzimidazole‐Imidazopyridine Hybrids as DNA Groove Binders

“…Presence of benzimidazole moiety and various substitutents around it have provided a wide spectrum of biological activities such as anticoagulants, anti‐inflammatory, antioxidants, proton pump inhibitors, hormone modulators, immunomodulators, antimicrobials, antivirals, antiparasites, anticancer, anti‐hypertensives, CNS stimulants as well as depressants, lipid level modulators, antidiabetics, etc. have created indispensable examples for development of new therapeutic agents . A great number of 2‐substituted benzimidazoles have been synthesized and their biological activities reported (Figure ) .…”