Diversity-oriented synthesis of marine polybrominated diphenyl ethers as potential KCNQ potassium channel activators

Marine natural products

“…Five bromophenol NPs were synthesised for the first time, 438 as was pyridinium alkaloid epi -tetrahydrohalicyclamine B. 439 The structure of echinosulfonic acid D has been synthesised, one year after it was revised independently by three groups as reported in last year's review.…”

Effects of sponge-derived polybrominated diphenyl ethers on human cancer cell α-N-acetylgalactosaminidase and bacterial α-d-galactosidase and their antioxidant activity

“…32 Spongean PBDEs activate KCNQ potassium channels, which predominantly express in the heart and cardiomyocytes. 33 Screening of 300 naturally occurring compounds showed 4,6-dibromo-2-(2 ′ ,4 ′ -dibromophenoxy) phenol and 4,5,6-tribromo-2-(2 ′ ,4 ′ -dibromophenoxy)phenol as substances with the potential for anticancer therapy. 34 Spongean PBDEs are bioaccumulated in the marine food web with the potential transfer to humans through seafood consumption; dietary ingestion is understood to be an important uptake pathway for many OH-/MeO-PBDEs.…”