Diverticulum of the heart

Edgett, Joseph W.; Nelson, William P.; Hall, Robert J.; Fishback, Malcolm E.; Jahnke, Edward J.

doi:10.1016/0002-9149(69)90505-0

Cited by 40 publications

(4 citation statements)

References 7 publications

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“…However, LV is elongated rather than truncated with involvement of the papillary muscles and surrounding myocardium (as opposed to isolated apical involvement). These conditions are usually deadly early in life owing to associated intracardiac and extracardiac abnormalities[ 33 , 34 ]; and (4) Congenital LV dysplasia with or without right ventricular dysplasia. On cardiac MRI, at tissue characterisation, diffuse transmural fibrofatty replacement is noted, whereas in ILVAH it is predominantly apical[ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Isolated left ventricular apical hypoplasia: Systematic review and analysis of the 37 cases reported so far

Bassareo¹,

Duignan²,

James³

et al. 2023

World J Clin Cases

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Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.

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Section: Discussionmentioning

confidence: 99%

Isolated left ventricular apical hypoplasia: Systematic review and analysis of the 37 cases reported so far

Bassareo¹,

Duignan²,

James³

et al. 2023

World J Clin Cases

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“…Congenital ventricular diverticulum usually occurs (70%) as a part of complex cardiac syndromes, most commonly with the Pentalogy of Cantrell, and frequently associated with sternal, pericardial, diaphragmatic, and thoracoabdominal wall defects. 1 It can originate from both ventricles while the left ventricular diverticulum is more frequently reported. [2][3][4] Ventricular diverticula could be classified as fibrous or muscular.…”

Section: Discussionmentioning

confidence: 99%

Congenital biventricular cardiac diverticula as a part of class III Cantrell’s syndrome: case report

et al. 2022

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Congenital cardiac ventricular diverticulum is an extremely rare condition that usually occurs as a part of Pentalogy of Cantrell and frequently associated with sternal, pericardial, diaphragmatic, and thoracoabdominal wall defects. The prognosis of the patient depends on the complexity of abnormalities. Herein, we report biventricular diverticula as a part of incomplete Cantrell’s syndrome in a 1-day-old newborn.

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“…[13] Cardiac abnormalities include VSD (100%), atrial septal defect (53%), pulmonary atresia (35%), ectopia cardis (20%), patent ductus arteriosus, tetrology of Fallot, and diverticulum. [1114] Associated defects include craniofacial abnormalities; hypoplasia of lung,[15] kidneys,[16] adrenal, and liver;[17] malrotation of gut; and limb defects. [15] Cantrell’s pentalogy is underreported as the association is not constant and there is incomplete expression.…”

Section: Discussionmentioning

confidence: 99%

“…Defects in the mesodermal development of the anterior transverse septum of the diaphragm are a probable cause. [14]…”

Section: Discussionmentioning

confidence: 99%

Case series: Congenital left ventricular diverticulum

Shah

Kumar

Shah

et al. 2010

Indian Journal of Radiology and Imaging

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Congenital left ventricular diverticulum is a rare cardiac malformation characterized by a localized outpouching from the cardiac chamber. The patient is usually asymptomatic. However, complications like embolism, infective endocarditis, arrhythmia and, rarely, rupture can be the initial presentation. Diagnosis can be established by USG, echocardiography, CT angiography, and MRI. We report here two neonates with congenital left ventricular apical diverticulum associated with epigastric hernia.

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Diverticulum of the heart

Cited by 40 publications

References 7 publications

Isolated left ventricular apical hypoplasia: Systematic review and analysis of the 37 cases reported so far

Isolated left ventricular apical hypoplasia: Systematic review and analysis of the 37 cases reported so far

Congenital biventricular cardiac diverticula as a part of class III Cantrell’s syndrome: case report

Case series: Congenital left ventricular diverticulum

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