Diz Osteoartritinde Sürekli ve Kesikli Ultrason Tedavilerinin Değerlendirilmesi: Randomize ve Plasebo Kontrollü Bir Klinik Çalışma

Abstract

This study evaluates effects of therapeutic ultrasound (continue, pulsed, placebo) treatment on the clinical and biochemical parameters in knee osteoarthritis. 30 patients (30-70 aged) diagnosed with knee osteoarthritis were randomly separated into three groups. The 1st group includes 10 patients given continue ultrasound treatment (1 MHz, 2W/cm2), the 2nd group consists of 10 patients given pulsed ultrasound treatment (1MHz, 2 W/cm2, 1:4) and 3th group includes 10 patients given placebo ultrasound treatment (switch off). The patients were assessed before and one month after the treatment with WOMAC, COMP, Hs CRP, MMP-1, MMP-3 levels in serum and CTX-II levels in urine. When the demographic characteristics were compared, no statistically significant difference was found between the three groups in terms of age, body mass index and radiological staging (p > 0.05). In terms of clinical parameters, there was an improvement in all three groups in the first month after treatment except WOMAC stiffness in pulsed and placebo groups, although no statistically significant difference was observed between the groups (p > 0.05). In the evaluation of biochemical parameters, there was no significant difference between the groups in terms of pre-treatment and post-treatment 1 month, whereas there was a statistically significant difference between the group 1 and group 3 in favor of group 3 (p = 0.019). The efficacy of therapeutic US (continuous / pulsed) which was applied short term and alone, on clinical and biochemical markers in knee osteoartrithis, has not been demonstrated.