dl-BETA-PHENYLISOPROPYLAMINES

Abstract

4-Hydroxy-l-(2',4',6'-tribiomophenyl)-5-methylpyrazole separates from a mixture of boiling chloroform and light petroleum (b. p. 60-80°) in short colorless prisms, m. p.

Khat Abuse in Yemen: A Population-Based Survey

“…It consists of fresh leaves of the shrub catha edulis, is purchased in local markets and is consumed by chewing (1). In the 30s Dr Gordon Alles (2) isolated from the dried plant a monoamine alkaloid called cathinone, otherwise called betaketoamphetamine, which is the main contributor to the stimulant effect of khat ( Figure 1). The WHO Expert Committee on Drug Dependence listed cathinone as a central nervous system stimulant about half as potent as amphetamine, and khat as an addicting drug (3).…”

“…The WHO Expert Committee on Drug Dependence listed cathinone as a central nervous system stimulant about half as potent as amphetamine, and khat as an addicting drug (3). The effects of Khat can be divided into three, (1) the stimulant effects which has enhanced its use for accomplishing study, hard work, and attending social events, (2) its immediate adverse effects including multiple general somatic symptoms like tiredness, gastrointestinal and cardiac complaints, (3) its serious adverse effects including myocardial infarction, hepatic cirrhosis, malignancy, stillbirth, and acute psychosis (1).…”

Solvent‐Free Nucleophilic Addition of N‐Alkylhydroxylamines to Substituted Nitroolefins: Formation of Nitrones by a Tandem process

“…The substituted nitrostyrenes and other a,b-unsaturated nitro compounds have been prepared by the condensation of the corresponding aldehydes with nitroethane. [10] The partial reduction has been carried out with utmost care to stop the reduction in the hydroxylamine stage using boron trifluoride and sodium borohydride, following a known procedure. [9] General Procedure for the Nucelophilic Addition of 1-Methyl-2-arylethyl Hydroxylamine to b-Nitrostyrenes 1-Methyl-2-arylethyl hydroxylamine (0.001 mol) was mixed with 0.001 mol of substituted b-methyl-b-nitrostyrene and ground well in a mortar.…”

“…The hydroxylamine under discussion was prepared by the controlled careful reduction [9] of b-methyl-b-nitrostyrene. [10] Nitroalkenes are also potential substrates for nucleophilic attack in a 1,4-fashion addition. Thus, we planned to effect nucleophilic addition of hydroxylamines 1 on substituted nitrostyrenes 2 in the expectation of getting secondary hydroxylamines.…”

Synthesis of Dextroamphetamine Sulfate and Methamphetamine Hydrochloride from D-Phenylalanine

“…dl-a-Methylphenethylamine and D-a,iV-dimethylphenethylamine have been prepared by several routes (4, [8][9][10][11][12]. The deuterium-labeled analogs of these compounds also have been synthesized (13,14).…”