DLP fabricating of precision GelMA/HAp porous composite scaffold for bone tissue engineering application

Song, Ping; Li, Mingxin; Zhang, Boqing; Gui, Xingyu; Han, Yanlong; Wang, Li; Zhou, Wenzheng; Guo, Likun; Zhang, Zhenyu; Li, Zhengyong; Zhou, Changchun; Fan, Yujiang; Zhang, Xingdong

doi:10.1016/j.compositesb.2022.110163

Cited by 89 publications

(51 citation statements)

References 39 publications

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“…GelMA was prepared according to the method published previously by our team. 26 Dopamine grafted GelMA (GelMA-DOPA) was synthesized by the amidation reaction between GelMA and dopamine hydrochloride with the catalysation of EDC and NHS. Briefly, 2.0 g GelMA was dissolved in 50 ml PBS (pH B 5) at 37 1C.…”

Section: Synthesis Of Dopamine Grafted Gelma (Gelma-dopa)mentioning

confidence: 99%

In situphoto-crosslinked adhesive hydrogel loaded with mesenchymal stem cell-derived extracellular vesicles promotes diabetic wound healing

Wang

Song

et al. 2023

J. Mater. Chem. B

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Section: Synthesis Of Dopamine Grafted Gelma (Gelma-dopa)mentioning

confidence: 99%

In situphoto-crosslinked adhesive hydrogel loaded with mesenchymal stem cell-derived extracellular vesicles promotes diabetic wound healing

Wang

Song

et al. 2023

J. Mater. Chem. B

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“…Presently, the most common methods for preparing pore scaffolds are freeze-drying ( Brougham et al, 2017 ), electrospinning ( Yan et al, 2020 ), and gas foaming ( Chen et al, 2021 ); however, these methods cannot effectively control the pore structure. With the update of 3D printing technology, new technologies such as digital light projection printing can quickly manufacture composites with complex pore structures, adjust the pore structure parameters ( Zhang et al, 2022a ; Song et al, 2022 ), and accurately control the shape of scaffolding. Therefore, geometric structures with different shapes can be accurately manufactured by computer aided design (CAD) ( Zopf et al, 2015 ), such as complex geometric objects or artificial organ frames.…”

Section: Influence Of Manufacturing Process On Scaffold Structurementioning

confidence: 99%

Study on the influence of scaffold morphology and structure on osteogenic performance

Zhou

Xiong²,

Liu³

et al. 2023

Front. Bioeng. Biotechnol.

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The number of patients with bone defects caused by various bone diseases is increasing yearly in the aging population, and people are paying increasing attention to bone tissue engineering research. Currently, the application of bone tissue engineering mainly focuses on promoting fracture healing by carrying cytokines. However, cytokines implanted into the body easily cause an immune response, and the cost is high; therefore, the clinical treatment effect is not outstanding. In recent years, some scholars have proposed the concept of tissue-induced biomaterials that can induce bone regeneration through a scaffold structure without adding cytokines. By optimizing the scaffold structure, the performance of tissue-engineered bone scaffolds is improved and the osteogenesis effect is promoted, which provides ideas for the design and improvement of tissue-engineered bones in the future. In this study, the current understanding of the bone tissue structure is summarized through the discussion of current bone tissue engineering, and the current research on micro-nano bionic structure scaffolds and their osteogenesis mechanism is analyzed and discussed.

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“…[ 153,154 ] GelMA hydrogel is therefore suited for a wide range of biological applications, including tissue engineering and regenerative medicine, as well as medication, growth factor, and gene delivery. [ 128,155,156 ] For cartilage and tooth regeneration, UV light‐crosslinked GelMA hydrogel has been employed to build tissue‐engineered cartilage‐ and prevascularized dental pulp‐like constructions. [ 157 ] 3D‐bioprinted chondroprogenitor cell‐laden articular cartilage GelMA hydrogel was proven to be highly effective than the hydrogel‐containing mesenchymal stem cells (MSCs) or chondrocytes in nonhypertrophic neo‐cartilage production.…”

Section: Photopolymers: Manufacturing and 3d Printingmentioning

confidence: 99%

Recent Advances in 3D Printing of Photocurable Polymers: Types, Mechanism, and Tissue Engineering Application

Randhawa

Dutta

Ganguly

et al. 2022

Macromolecular Bioscience

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The conversion of liquid resin into solid structures upon exposure to light of a specific wavelength is known as photopolymerization. In recent years, photopolymerization‐based 3D printing has gained enormous attention for constructing complex tissue‐specific constructs. Due to the economic and environmental benefits of the biopolymers employed, photo‐curable 3D printing is considered an alternative method for replacing damaged tissues. However, the lack of suitable bio‐based photopolymers, their characterization, effective crosslinking strategies, and optimal printing conditions are hindering the extensive application of 3D printed materials in the global market. This review highlights the present status of various photopolymers, their synthesis, and their optimization parameters for biomedical applications. Moreover, a glimpse of various photopolymerization techniques currently employed for 3D printing is also discussed. Furthermore, various naturally derived nanomaterials reinforced polymerization and their influence on printability and shape fidelity are also reviewed. Finally, the ultimate use of those photopolymerized hydrogel scaffolds in tissue engineering is also discussed. Taken together, it is believed that photopolymerized 3D printing has a great future, whereas conventional 3D printing requires considerable sophistication, and this review can provide readers with a comprehensive approach to developing light‐mediated 3D printing for tissue‐engineering applications.

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DLP fabricating of precision GelMA/HAp porous composite scaffold for bone tissue engineering application

Cited by 89 publications

References 39 publications

In situphoto-crosslinked adhesive hydrogel loaded with mesenchymal stem cell-derived extracellular vesicles promotes diabetic wound healing

In situphoto-crosslinked adhesive hydrogel loaded with mesenchymal stem cell-derived extracellular vesicles promotes diabetic wound healing

Study on the influence of scaffold morphology and structure on osteogenic performance

Recent Advances in 3D Printing of Photocurable Polymers: Types, Mechanism, and Tissue Engineering Application

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