DNA-binding and cleavage studies of chiral Mn(III) salen complexes

Peng, Bin; Zhou, Wen-Hui; Yan, Lin; Liu, Hanwen; Zhu, Li

doi:10.1007/s11243-008-9183-7

Cited by 28 publications

(12 citation statements)

References 22 publications

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“…From K SV data external binding with moderate intercalation was speculated. Similar types of observation were found with Mn-salen complexes [40]. …”

Section: Fluorescence Spectroscopic Studiessupporting

confidence: 86%

DNA interaction, SOD, peroxidase and nuclease activity studies of iron complex having ligand with carboxamido nitrogen donors

Ghosh

Tyagi

Kumar

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…From K SV data external binding with moderate intercalation was speculated. Similar types of observation were found with Mn-salen complexes [40]. …”

Section: Fluorescence Spectroscopic Studiessupporting

confidence: 86%

DNA interaction, SOD, peroxidase and nuclease activity studies of iron complex having ligand with carboxamido nitrogen donors

Ghosh

Tyagi

Kumar

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…17,18 Some manganese complexes, e.g. [Mn(TMPyP)](OAc) 5 (TMPyP = meso-tetrakis(4-N-methylpyridinumyl) porphyrinato), 19 manganese-salen derivatives, 20,21 [Mn(L) 23 also present intercalative DNA-binding capacity or significant DNA/antitumor activity. Therefore the synthesis and characterization of new manganese complexes are of great importance not only for developing novel chemotherapeutics and highly sensitive diagnostic agents but also for understanding the role and mechanism of manganese complexes in biological system.…”

Section: Introductionmentioning

confidence: 99%

Crystal structure, supramolecular self-assembly and interaction with DNA of a mixed ligand manganese(II) complex

Sun¹,

Dong²,

Wang³

et al. 2011

J. Braz. Chem. Soc.

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Um complexo misto de manganês(II), [Mn(sal)(phen) 2 ]ClO 4 (1) (sal = salicilaldeído, phen = 1,10-fenantrolina), foi sintetizado e caracterizado por análise elementar e difração de raio-X de monocristais. A análise dos difratogramas revelou que o complexo 1 cristaliza no grupo espacial monoclínico P2 1 /n. A unidade assimétrica do complexo é composta do cátion complexo [Mn(sal)(phen) 2 ] + e do ânion perclorato não coordenado. O manganês(II) está num ambiente de coordenação MnN 4 O 2 de geometria octaédrica bem distorcida. Quatro tipos de empilhamento p-p envolvendo ligantes fenantrolina e salicilaldeído estão envolvidos na auto-montagem supramolecular. Estas interações de empilhamento aromático cooperam com ligações de hidrogênio para a montagem de uma fascinante arquitetura supramolecular 3D com o complexo. Estudos de espectroscopia de absorção eletrônica e de titulação monitorando-se a fluorescência de 1 com DNA de timo de bezerro sugerem a ligação do complexo por intercalação com uma constante de formação igual a 7,97×10 3 L mol −1 e uma constante de supressão de Stern-Volmer de 1,34×10 4 L mol −1 .A mixed ligand manganese(II) complex, [Mn(sal)(phen) 2 ]ClO 4 (1) (sal = salicylaldehyde, phen = 1,10-phenanthroline), has been synthesized and characterized by elemental analysis and single crystal X-ray diffractometry. The structural analysis revealed that complex 1 crystallizes in the monoclinic space group P2 1 /n. The asymmetric unit of the complex is comprised of [Mn(sal)(phen) 2 ] + complex cation and uncoordinated perchlorate anion. The manganese(II) is located in a seriously distorted octahedral MnN 4 O 2 coordination environment. Four types of p-p stacking modes involving phenanthroline and salicylaldehyde ligands are involved in the supramolecular self-assembly. These aromatic stacking interactions cooperate with hydrogen bonding to assemble the complex into a fascinating 3D supramolecular architecture. Electronic absorption spectroscopy and fluorescence titration studies of the interaction between complex 1 and calf thymus DNA suggest an intercalative binding mode with a constant of 7.97×10 3 L mol −1 and a Stern-Volmer quenching constant of 1.34×10 4 L mol −1 .Keywords: manganese(II) complex, crystal structure, supramolecular self-assembly, DNA interaction, spectrum IntroductionMuch attention has been given to rational design, synthesis and characterization of new transition metal complexes in the past decades because some of them can interact with DNA acting as probes for nucleic acid structure manipulation or exhibiting nuclease property. [1][2][3][4][5] Metal complex can bind to DNA in non-covalent way such as by electrostatic interaction, minor or major groove-bound fashion and intercalation. 6,7 Considerable efforts are yet necessary to develop novel metal complexes binding to DNA through an intercalative association because of their unique properties and applications. [8][9][10][11][12][13] A metallointercalator binds DNA through the insertion of a planar polycyclic aromatic 23 also present int...

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“…Salen-Mn complexes possess ability to bind with free-radicals like hydrogen peroxide decomposition, superoxide anion (O2 - ) dismutase, catalase, water oxidation and ribonuclease reduction, and DNA and proteins. It has been reported that Salen-Mn (III) has strong antioxidant activity [ 25 ], moreover, it has the DNA binding and cleavage activity [ 26 , 27 ]. Mn(III)-salen complexes are shown to possess superoxide dismutase (SOD) and catalase activities and are considered as synthetic SOD mimics [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Salen-Mn compounds induces cell apoptosis in human prostate cancer cells through promoting AMPK activity and cell autophagy

Tang

Jia

et al. 2017

Oncotarget

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Currently only docetaxel has been approved to be used in the chemotherapy of prostate cancer and new drugs are urgent need. Salen-Mn is a novel type of synthetic reagent bionic and exerts remarkable anticancer activities. However, the effect of Salen-Mn on human prostate cancer has not been elucidated yet. In this study, we found that treatment of PC-3 and DU145 human prostate cancer cells with Salen-Mn inhibited cell growth in dose and time dependent manner. Moreover, Salen-Mn induced cell apoptosis, and increased the expression of apoptotic proteins, such as cleaved caspase-3, cleaved PARP, and Bax, in PC-3 and DU145 prostate cancer cells. Furthermore, we found that Salen-Mn induced expression of LC3-I/II, which is protein marker of cell autophagy, in both dose and time dependent manners; in addition, Salen-Mn increased the phosphorylation of AMPK, suggesting that Salen-Mn increase cell autophagy through activating AMPK pathway. On the other hand, when PC-3 and DU145 cells were treated with Salen-Mn and 3-MA, an inhibitor of cell autophagy, the inhibitory effect of Salen-Mn on cell growth and the induction of apoptotic proteins were decreased. In addition, we found that Salen-Mn inhibited the growth of PC-3 cell xenografts in nude mice. In summary, our results indicate that Salen-Mn suppresses cell growth through inducing AMPK activity and autophagic cell death related cell apoptosis in prostate cancer cells and suggest that Salen-Mn and its derivatives could be new options for the chemical therapeutics in the treatment of prostate cancer.

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DNA-binding and cleavage studies of chiral Mn(III) salen complexes

Cited by 28 publications

References 22 publications

DNA interaction, SOD, peroxidase and nuclease activity studies of iron complex having ligand with carboxamido nitrogen donors

DNA interaction, SOD, peroxidase and nuclease activity studies of iron complex having ligand with carboxamido nitrogen donors

Crystal structure, supramolecular self-assembly and interaction with DNA of a mixed ligand manganese(II) complex

Salen-Mn compounds induces cell apoptosis in human prostate cancer cells through promoting AMPK activity and cell autophagy

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