DNA-binding and photocleavage studies of metallofluorescein–porphyrin complexes of zinc(II) and copper(II)

Lu, Jiazheng; Pan, Weijian; He, Rongwei; Jin, Shuqiang; Liao, Xiangwen; Wu, Bin; Zhao, Ping; Guo, Haiwei

doi:10.1007/s11243-012-9615-2

Cited by 9 publications

(3 citation statements)

References 34 publications

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“…The presence of radical scavengers (DMSO) and a singlet oxygen quencher (NaN 3 ) did not significantly reduce the efficiency of DNA cleavage (Figure 4, lanes 6, 7), ruling out the possibility of the involvement of diffusible hydroxyl radicals and a singlet oxygen in the cleavage. 8,39 The copper(II) cluster may be capable of bringing about hydrolytic cleavage of DNA. This is not surprising since hydrolytic cleavage requires the coordinative binding of the copper(II) cluster to either DNA bases or phosphate.…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…5 Afterwards, large numbers of copper(II) complexes and other metal complexes, particularly of the first row transition metals, have been synthesized, characterized, and evaluated for their nuclease mimicking and anticancer activities. [6][7][8] The two modes of binding with DNA residues have been identified, i.e., intercalating and covalent binding.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, structure characterization, DNA binding, and cleavage properties of mononuclear and tetranuclear cluster of copper(II) complexes

Vafazadeh

Willis²,

Heidari³

et al. 2015

ACSi

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Two copper(II) complexes, cluster 1, and mononuclear 2, have been synthesized by reacting acetylacetone and benzohydrazide (1:1 ratio for 1 and 1:2 ratio for 2) with CuCl 2 in a methanol solution. In 2, which is a new complex, the ligand acts as a tetradentate which binds the metal ion via two amide-O atoms and two imine-N atoms providing an N 2 O 2 square-planar around the copper(II) ion. The absorption spectra data evidence strongly suggested that the two copper(II) compounds could interact with CT-DNA (intrinsic binding constant, K b = 0.45 × 10 4 M-1 for 1 and K b = 2.39 × 10 4 M-1 for 2). The super coiled plasmid pBR322 DNA cleavage ability was studied with 1 and 2 in the presence and absence of H 2 O 2 as an oxidant. In both the absence and the presence of an oxidizing agent, complex 2 exhibited no nuclease activity. However, even in the absence of an oxidant, complex 1 exhibited significant DNA cleavage activity.

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Section: Supplementary Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, structure characterization, DNA binding, and cleavage properties of mononuclear and tetranuclear cluster of copper(II) complexes

Vafazadeh

Willis²,

Heidari³

et al. 2015

ACSi

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“…Metal complexes that can bind to and cleave DNA are potential antitumor agents . Human serum albumin (HSA) is the major soluble protein in the human circulatory system, and can transport and dispose of various endogenous and exogenous compounds .…”

Section: Introductionmentioning

confidence: 99%

DNA/HSA interaction and nuclease activity of an iron(III) amphiphilic sulfonated corrole

et al. 2015

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The DNA binding of amphiphilic iron(III) 2,17-bis(sulfonato)-5,10,15-tris(pentafluorophenyl)corrole complex (Fe-SC) was studied using spectroscopic methods and viscosity measurements. Its nuclease-like activity was examined by using pBR322 DNA as a target. The interaction of Fe-SC with human serum albumin (HSA) in vitro was also examined using multispectroscopic techniques. Experimental results revealed that Fe-SC binds to ct-DNA via an outside binding mode with a binding constant of 1.25 × 10(4) M(-1). This iron corrole also displays good activity during oxidative DNA cleavage by hydrogen peroxide or tert-butyl hydroperoxide oxidants, and high-valent (oxo)iron(V,VI) corrole intermediates may play an important role in DNA cleavage. Fe-SC exhibits much stronger binding affinity to site II than site I of HSA, indicating a selective binding tendency to HSA site II. The HSA conformational change induced by Fe-SC was confirmed by UV/Vis and CD spectroscopy.

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Synthesis, characterization, DNA binding and cleavage properties of a ternary copper(II) Schiff base complex

et al. 2014

Transition Met Chem

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DNA-binding and photocleavage studies of metallofluorescein–porphyrin complexes of zinc(II) and copper(II)

Cited by 9 publications

References 34 publications

Synthesis, structure characterization, DNA binding, and cleavage properties of mononuclear and tetranuclear cluster of copper(II) complexes

Synthesis, structure characterization, DNA binding, and cleavage properties of mononuclear and tetranuclear cluster of copper(II) complexes

DNA/HSA interaction and nuclease activity of an iron(III) amphiphilic sulfonated corrole

Synthesis, characterization, DNA binding and cleavage properties of a ternary copper(II) Schiff base complex

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