Synthesis, characterization, DNA binding and cleavage properties of a ternary copper(II) Schiff base complex

Synthesis, characterisation and biological studies of mixed-ligand nickel (II) complexes containing imidazole derivatives and thiosemicarbazide Schiff bases

“…The CT-DNA was dissolved in 25 ml of buffer solution [33]. The concentration of CT-DNA was calculated according to Beer-Lambert's Law A = εbc, where ε is the molar extinction coefficient, 6600 M -1 cm -1 at 260 nm [34]. The calculated DNA concentration was 5.136 x 10 -5 M. The complexes were dissolved in a mixture of DMSO/buffer (3:7).…”

A new ternary Cu (II) complex with 4,7‐dimethyl‐1,10‐phenanthroline and NOO‐type tridentate Schiff base ligand: Synthesis, crystal structure, biomacromolecular interactions, and radical scavenging activities

“…The calculated K b values for H 2 L Schiff base ligand and ternary Cu (II) complex were found to be of lower magnitude than the classical intercalator ethidium bromide, EB, ( K b = 1.23 × 10 5 M −1 , log K b = 5.09). [ 47 ] But the K b values for H 2 L Schiff base ligand and ternary Cu (II) complex are comparable to other copper (II) complexes containing Schiff base and 1,10‐phenanthroline: [Cu (Schiff base)(phen)] 2 (log K b = 4.29, Schiff base: 4‐chloroanthranilic acid salicylaldehyde), [ 43 ] [Cu (Schiff base)(phen)H 2 O] (log K b = 5.78, hypochromism 8.18%, Schiff base: (E)‐2‐((2‐hydroxy‐4‐methoxyphenyl)(phenyl) methylene amino)benzoic acid), [ 44 ] [Cu (Schiff base)(phen)]ClO 4 (log K b = 5.15, Schiff base: 2‐[(3‐Methylamino‐propylimino)methyl]phenol), [ 45 ] [Cu (Schiff base)(phen)]MeOH (log K b = 6.02, hypochromism 41.04%, Schiff base: 4‐chloro2‐[(2‐hydroxyphenyl)iminomethyl]phenol). [ 46 ] The results displayed that the K b order is ternary Cu (II) complex > H 2 L Schiff base ligand.…”

“… Note. ♣, in this study; Schiff base, (E)‐2‐((2‐hydroxy‐4‐methoxyphenyl)(phenyl)methyleneamino)benzoic acid in Li et al [ 43 ] ; Schiff base, 2‐[(3‐methylamino‐propylimino)methyl]phenol in Bhunai et all [ 45 ] ; Schiff base, 4‐chloro‐2‐[(2‐hydroxyphenyl)iminomethyl]phenol in Ma et al [ 46 ] …”

Synthesis, crystal structure, DNA binding and cleavage studies of copper(II) complexes with isoxazole Schiff bases

“…CT-DNA stock solution was prepared by diluting DNA to Tris-HCl/NaCl buffer (pH = 7.2, 5 mM Tris-HCl, 50 mM NaCl). 1 H-NMR and 13 Viscosity measurements were performed using an Ostwald viscometer (Vensil).…”

“…Copper as an essential element for human beings with its bio essential activity and oxidative nature has attracted numerous inorganic chemists to address medicinal applications of Cu(II) complexes [3][4][5][6][7][8]. Copper(II) complexes containing heterocyclic bases have been extensively explored in virtue of their strong interactions with DNA via surface associations or intercalation [9][10][11][12] and potential DNA cleavage activities via hydrolytic, photolytic and oxidative mechanisms [13][14][15][16][17][18]. Square planar complexes containing an aromatic moiety can bind to DNA by intercalation and stabilize the DNA double helix [19,20].…”