DNA-compatible synthesis of enaminones via amination of allenic ketones

Abstract

Construction of DNA-encoded chemical libraries which contain focused pharmacophores is of great value for high-throughput hit discovery. Enaminone serves as a privileged scaffold in a series of bioactive compounds, and...

Isothiocyanate intermediates facilitate divergent synthesis of N-heterocycles for DNA-encoded libraries

“…1a). 5 Incorporating the concept of DOS, we aim to elaborate the in situ conversion strategies for facilely transforming prevalent primary amines into versatile intermediates within DELs, 6 thus enabling the efficient synthesis of diverse drug-like heterocyclic scaffolds.…”