DNA computing for combinational logic

Zhang, Chuan; Ge, Lulu; Zhuang, Yuchen; Shen, Ziyuan; Zhong, Zhiwei; Zhang, Zaichen; You, Xiaohu

doi:10.1007/s11432-018-9530-x

Cited by 10 publications

(9 citation statements)

References 86 publications

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“…Solution is probably the mostly and best studied environment for operation of DLG biosensors, where inputs, DLG, and outputs are freely diffusive depending on environmental temperatures 25 . The diffusion‐based kinetics is critical for the speed of logic operation, and the global diffusion of all components affects the logic operation efficiency and complexity.…”

Section: Dlg‐based Biosensors In Solutionmentioning

confidence: 99%

Biosensors based on DNA logic gates

Yin

Wang

Chen

et al. 2020

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Biosensor is a device that responds to a particular target in a selective way by incorporation of biological recognition as sensing unit. For practical biomedical applications, a digital output (a qualitative YES/NO answer) is highly demanded for certain end‐user or point‐of‐care applications. Boolean logic, which can be applied to any type of information expressed as 0 (NO) and 1 (YES), is widely employed to achieve such qualitative analysis. Over the past decade, owing to DNA's advantages of stability, accessibility, and manipulability, significant research efforts have been focused on the design and application of DNA logic gates (DLG)‐based biosensors capable of implementing logic‐gated biomedical functions. This review summarizes the existed representative examples and the advanced developments of DLG biosensors, and discusses the limitations and the future directions on the development of novel nanosensors based on DNA logic operations for realizing highly efficient diagnosis.

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Section: Dlg‐based Biosensors In Solutionmentioning

confidence: 99%

Biosensors based on DNA logic gates

Yin

Wang

Chen

et al. 2020

VIEW

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“…As one of the most important branches in the eld of bioengineering, the arti cial logic networks are committed to using molecules to simulate the logic operations of silicon-based digital circuits with the ultimate goal of constructing submicroscopic computers [1][2][3][4][5] . Compared with the existing arti cial molecules, DNA is naturally biocompatible 6 , so it is easier to accommodate to the aqueous biological environment [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Erasable and Field Programmable DNA Circuits Based on Configurable Logic Blocks

Xiao

Liu

Zhai

et al. 2023

Preprint

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DNA is commonly employed as a substrate for the building of artificial logic networks due to its excellent biocompatibility and programmability. Till now, DNA logic circuits have been rapidly evolving to accomplish advanced operations. Nonetheless, the process of creating DNA logic circuits according to personal needs (logical truth table) requires extensive knowledge on digital circuits. Moreover, even after the researchers endeavor to build a DNA circuit, it lacks field programmability and thereby being disposable and inconvenient. Herein, inspired by the Configurable Logic Block (CLB) paradigm in silicon digital circuits, we present the CLB-based field-programmable DNA circuit that uses clip strands as its operation-controlling signals. It substantially simplifies the construction of desired circuits by establishing the relationship between circuits and operation-controlling strands. Additionally, the field programmability enables users to realize diverse functions with limited hardware. We firstly constructed CLB-based basic logic gates (OR and AND), and effectively demonstrate their eras ability and field programmability. Furthermore, by simply adding the appropriate operation-controlling strands, we achieved multiple rounds of switch among 5 different logic operations on a single two-layer circuit. In addition, we successfully built a circuit to implement two fundamental binary calculators: half-adder and half-subtractor, proving that our design could imitate silicon-based binary circuits. Finally, we built a comprehensive CLB-based circuit that enabled multiple rounds of switch among 7 different logic operations including half-adding and half-subtracting. Overall, the CLB-based field-programmable circuit greatly streamlines the process to build DNA circuits and immensely enhances their practicability. We believe our design could be widely used in DNA logic networks due to its efficiency and convenience.

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“…12 Such designed DNA sequences can be chemically synthesised by an automated DNA synthesiser, making DNA a practical building block for artificial reaction systems. 13,14 Various logic circuits proposed in DNA computing demonstrate complex information processing abilities implemented as chemical reactions. [15][16][17][18][19][20] However, these systems are usually implemented in a well-mixed test tube, and thus, they are limited in utilising spatial inhomogeneity.…”

Section: Introductionmentioning

confidence: 99%