DNA damage in mouse lymphocytes exposed to curcumin and copper

Urbina-Cano, Patricia; Bobadilla-Morales, Lucina; Ramírez-Herrera, Mario Alberto; Corona‐Rivera, Jorge Román; Mendoza-Magaña, María Luisa; Troyo-Sanromán, Rogelio; Corona‐Rivera, Alfredo

doi:10.1007/bf03194648

Cited by 44 publications

(24 citation statements)

References 31 publications

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“…The induction of DNA damage that we observed in HEp-2 and 7T cells following the treatment with curcumin is in agreement with those previously reported, despite differences in the type of cells and experimental conditions used (Cao et al, 2006;Huang et al, 2011;Jiang et al, 2010;Lin et al, 2008;Lopez-Lazaro et al, 2007;Su et al, 2006;Urbina-Cano et al, 2006). Although we have expected that more oxidative DNA damage (like oxidized purines) would appear in HEp-2 and 7T cells because of ROS induction, strand breaks were predominant and correlated with cytotoxicity.…”

Section: Discussionsupporting

confidence: 93%

Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation

Rak

Čimbora‐Zovko

Gajski

et al. 2013

Toxicology in Vitro

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Section: Discussionsupporting

confidence: 93%

Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation

Rak

Čimbora‐Zovko

Gajski

et al. 2013

Toxicology in Vitro

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“…Although the increase in ROS was transient, presumably because of a subsequent elevation in glutathione, cell viability was nevertheless decreased. Similarly, curcumin-mediated DNA damage was reported in mouse lymphocytes using a comet assay [222]. In contrast to these studies, Polasa et al [223] reported that curcumin inhibited B(a)P-induced strand breaks in human peripheral blood lymphocytes.…”

Section: Cautionary Talesmentioning

confidence: 85%

Curcumin: From ancient medicine to current clinical trials

Hatcher

Planalp

Cho

et al. 2008

Cell. Mol. Life Sci.

1,654

1,159

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Abstract. Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. The pleiotropic activities of curcumin derive from its complex chemistry as well as its ability to influence multiple signaling pathways, including survival pathways such as those regulated by NF-kB, Akt, and growth factors; cytoprotective pathways dependent on Nrf2; and metastatic and angiogenic pathways. Curcumin is a free radical scavenger and hydrogen donor, and exhibits both pro-and antioxidant activity. It also binds metals, particularly iron and copper, and can function as an iron chelator. Curcumin is remarkably non-toxic and exhibits limited bioavailability. Curcumin exhibits great promise as a therapeutic agent, and is currently in human clinical trials for a variety of conditions, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis and Alzheimers disease.

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“…21 Accumulating data have demonstrated since then that curcumin can induce DNA damage and chromosomal alterations both in vitro and in vivo at concentrations similar to those reported to exert beneficial effect. [22][23][24][25][26][27][28][29][30] For instance, curcumin concentrations of 2.5 and 5 lg mL À1 were shown to induce DNA damage to both the mitochondrial and nuclear genomes in cells. 28 These reports raise concern about curcumin safety, as the induction of DNA alterations is a common event in carcinogenesis.…”

Section: Dear Editormentioning

confidence: 99%

The dark side of curcumin

Burgos-Morón

Calderón-Montaño

Salvador

et al. 2010

Intl Journal of Cancer

304

210

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Dear Editor,Curcumin is a yellow-orange pigment obtained from the plant Curcuma longa. The powdered rhizome of this plant, called turmeric, is a common ingredient in curry powders and has a long history of use in traditional Asian medicine for a wide variety of disorders. In the last decade a large number of reports have been published on the beneficial effects of curcumin, and it has repeatedly been claimed that this natural product is efficient and safe for the prevention and treatment of several diseases including cancer. 1-3 It is not surprising, therefore, that curcumin is currently sold as a dietary supplement and that numerous clinical trials are ongoing or recruiting participants to evaluate curcumin activity. But there is accumulating evidence that curcumin may not be so effective and safe. Because such evidence is not generally acknowledged, the purpose of this letter is to briefly review the negative properties of curcumin so that they can be balanced against its beneficial effects.Most of the evidence that supports the therapeutic potential of curcumin is mainly based on in vitro studies in which curcumin was tested at concentrations in the micromolar range. Several reports have demonstrated, however, that the plasma concentrations of curcumin in people taking relatively high oral doses of this compound are very low, typically in the nanomolar range (reviewed in Ref. 4). For instance, a recent study examined the pharmacokinetics of a curcumin preparation in 12 healthy human volunteers 0.25-72 hr after an oral dose of 10 or 12 g. Using a high-performance liquid chromatography assay with a limit of detection of 50 ng mL À1 , only 1 subject had detectable free curcumin at any of the time points assayed. 5 The fact that curcumin also undergoes extensive metabolism in intestine and liver 6,7 means that high concentrations of curcumin cannot be achieved and maintained in plasma and tissues after oral ingestion. This is a major obstacle for the clinical development of this agent and suggests that the therapeutic potential of oral curcumin is limited. The low clinical efficiency of curcumin in the treatment of several chronic diseases such as Alzheimer's disease and cardiovascular diseases has been discussed recently. 8 As far as cancer is concerned, in vitro studies have demonstrated that cancer cells do not die unless they are exposed to curcumin concentrations of 5-50 lM for several hours. 4,9,10 Because of its poor bioavailability, these concentrations are not achieved outside the gastrointestinal tract when curcumin is taken orally. Because of its extensive metabolism in intestine and liver, these concentrations cannot be maintained for several hours in the gastrointestinal tract. This suggests that the chemotherapeutic potential of oral curcumin is limited even for the treatment of cancers of the gastrointestinal tract. Accordingly, when 15 patients with advanced colorectal cancer were treated with curcumin at daily doses of 3.6 g for up to 4 months, no partial responses to treatment or decreases in tu...

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DNA damage in mouse lymphocytes exposed to curcumin and copper

Cited by 44 publications

References 31 publications

Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation

Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation

Curcumin: From ancient medicine to current clinical trials

The dark side of curcumin

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