DNA dot‐blot hybridization implicates human papillomavirus type 11‐DNA in epithelioma cuniculatum

Knobler, Robert; Schneider, S; Neumann, R; Bodemer, Walter; Radlwimmer, Bernhard; Aberer, Elisabeth; Söltz-Szöts, J; Gebhart, W.

doi:10.1002/jmv.1890290107

Cited by 59 publications

(45 citation statements)

References 18 publications

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“…A link to human papillomavirus (HPV) type-11 has also been suggested [17]. So far, the association of CC with low risk HPV has been site-specific, being reported only in cutaneous sites [17]. In both our cases, there was no significant expression of p16 on immunohistochemistry, arguing against high risk HPV as an etiological factor.…”

Section: Discussionmentioning

confidence: 58%

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Carcinoma Cuniculatum of the Esophagus and Tongue: Report of Two Cases, Including TP53 Mutational Analysis

Goh

Venkateswaran

Leow

et al. 2014

Head and Neck Pathol

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Carcinoma cuniculatum (CC) is a rare variant of extremely well differentiated squamous cell carcinoma. We present the clinicopathological features of two cases of CC; one lingual and one esophageal case with a molecular genetic study regarding the TP53 gene mutational status. Case 1 was a 62 year old male with enlarging chronic ulcer in the tongue. Case 2 was a 77 year old male with progressive dysphagia and odynophagia. Both patients were treated surgically. Both tumors showed deeply invaginating, keratin-filled, burrowing crypts lined by very well differentiated squamous epithelium. The esophageal tumor showed varying degrees of reactive nuclear atypia largely limited to the areas with dense intratumoral infiltration of neutrophils. No mutation of TP53 was identified in the esophageal case. Cytologic atypia limited to areas of significant acute inflammation may occur in CC and should, in the absence of aggressive stromal invasion, not preclude a diagnosis of CC.

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Section: Discussionmentioning

confidence: 58%

“…Etiopathogenetic possibilities that have been discussed by various investigators include smoking, alcohol, reflux and chronic ulcers [2,3,16]. A link to human papillomavirus (HPV) type-11 has also been suggested [17]. So far, the association of CC with low risk HPV has been site-specific, being reported only in cutaneous sites [17].…”

Section: Discussionmentioning

confidence: 99%

Carcinoma Cuniculatum of the Esophagus and Tongue: Report of Two Cases, Including TP53 Mutational Analysis

Goh

Venkateswaran

Leow

et al. 2014

Head and Neck Pathol

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“…Whilst the presence of HPV DNA has been demonstrated in CC at cutaneous sites [10,11] [6,9]. Therefore, the association of HPV and CC remains, at best, a site-specific observation.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma Cuniculatum Arising in the Tongue

Thavaraj

Cobb

Kalavrezos

et al. 2011

Head and Neck Pathol

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Carcinoma cuniculatum (CC) is a rare, distinct clinico-pathological variant of squamous cell carcinoma (SCC) that is defined histologically by the characteristic infiltrative pattern of a deep, broad, and complex proliferation of stratified squamous epithelium with keratin cores and keratin-filled crypts. Herein, we present a case report of CC of the oral tongue and discuss its diagnosis, management, and outcome, as well as briefly review the world literature. To our knowledge, this is the first documented case of CC of the tongue to be reported in the English literature. We draw attention to its clinico-pathological features and highlight that awareness of this entity as a distinct variant of SCC facilitates its correct management.

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“…The importance of human papillomavirus in carcinoma cuniculatum in the literature is equivocal. 16,17 The differential diagnoses for carcinoma cuniculatum of the penis include classic verrucous carcinoma, mixed verrucous carcinoma and condylomatous carcinoma. The nomenclature and morphologic definition of carcinoma cuniculatum is not uniform, and some authors have even equated it with verrucous carcinoma.…”

Section: Discussionmentioning

confidence: 99%

A rare case of carcinoma cuniculatum of the penis in a 55-year-old

Lau

Chang

Gómez

et al. 2013

CUAJ

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A rare case of carcinoma cuniculatum of the penis in a 55-year-old AbstractCarcinoma cuniculatum of the penis is an extremely rare variant of squamous cell carcinoma characterized by an endophytic deeply branching and burrowing growth pattern. One documented case series demonstrated afflicted patients ranging in age from 73-83 years with the tumour located on the glans penis, coronal sulcus or foreskin. We report a case of a 55-year-old with disease located on the ventral aspect of the shaft of the penis. The tumour was invasive into the deep dermal connective tissue, comparatively superficial to all previous documented cases. He subsequently underwent a partial penectomy. The case is discussed with a brief review of the literature.

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DNA dot‐blot hybridization implicates human papillomavirus type 11‐DNA in epithelioma cuniculatum

Cited by 59 publications

References 18 publications

Carcinoma Cuniculatum of the Esophagus and Tongue: Report of Two Cases, Including TP53 Mutational Analysis

Carcinoma Cuniculatum of the Esophagus and Tongue: Report of Two Cases, Including TP53 Mutational Analysis

Carcinoma Cuniculatum Arising in the Tongue

A rare case of carcinoma cuniculatum of the penis in a 55-year-old

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