DNA Dynamics under Periodic Force Effects

Svidlov, Alexander; Drobotenko, M. I.; Басов, А. А.; Gerasimenko, E. O.; Малышко, В. В.; Елкина, А. А.; Барышев, М. Г.; Джимак, С. С.

doi:10.3390/ijms22157873

Cited by 18 publications

(8 citation statements)

References 30 publications

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“…Absorption of microwave radiation by DNA has been observed to induce changes in living organisms [42,43], but the exact mechanism by which microwaves interfere with DNA function is unknown. Exposure of DNA and protein molecules to microwave radiation does not change their structure, but can, under certain conditions, affect their chemical bonds [44]. Experiments conducted by Shamis et al [45] have demonstrated that exposing E. coli cells to microwave radiation under sublethal temperature conditions causes the cell membrane to undergo a reversible, electrokinetic induction without any bactericidal effects.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Electromagnetic Microwave Radiation on Methane Fermentation of Selected Energy Crop Species

2021

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The aim of the present study was to determine how thermal stimulation via electromagnetic microwave radiation impacts the yields of biogas and methane produced by methane fermentation of five selected energy crop species in anaerobic reactors. The resultant performance was compared with that of reactors with conventional temperature control. The highest biogas production capacity was achieved for maize silage and Virginia mallow silage (i.e., 680 ± 28 dm3N/kgVS and 506 ± 16 dm3N/kgVS, respectively). Microwave radiation as a method of heating anaerobic reactors provided a statistically-significantly boost in methane production from maize silage (18% increase). Biomethane production from maize silage rose from 361 ± 12 dm3N/kgVS to 426 ± 14 dm3N/kgVS. In the other experimental variants, the differences between methane concentrations in the biogas were non-significant.

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Section: Discussionmentioning

confidence: 99%

The Effect of Electromagnetic Microwave Radiation on Methane Fermentation of Selected Energy Crop Species

2021

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“…В качестве перспективных лабораторных маркеров наркопатологии рассматривают различные молекулы, образующиеся в организме больных в ответ на введение наркотической субстанции. Такими молекулами могут быть некоторые специфические белки нервной ткани, субстраты эндотоксикоза, нейромедиаторы и ферменты их обмена, рецепторы нейромедиаторов и антитела к ним, про-и противовоспалительные факторы, такие как цитокины, компоненты антиоксидантной системы и маркеры окислительного стресса [3][4][5][6]. Наиболее интересными ввиду более высокой специфичности являются белковые маркеры.…”

Section: Introductionunclassified

Analysis of Protein Markers in Plasma of Patients with Drug Dependence Syndrome: Observational Clinical Study

Bykov

Lyubchenko

Popov

et al. 2023

Kuban. nauсh. med. vestnik

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Background. In drug addiction treatment, the diagnostic process is based on the chemical toxicological determination of the intoxication substrate or its metabolite. Laboratory monitoring and prediction issues that could form the basis of secondary prevention remain unresolved. Specific nervous tissue proteins are considered to be the most promising laboratory markers of drug pathology.Objective — to determine some potential biomarkers of protein-chemical nature in the plasma of patients with drug dependence syndrome.Methods. The study was conducted according to the design of an observational clinical trial at the Narcological Dispensary of Krasnodar Krai in the period from 07.2021 to 07.2022. The main group (group 2) included 31 patients diagnosed with substance dependence syndrome. The control group (group 1, n = 15) consisted of healthy subjects submitted to occupational medical examinations. During the detoxification-stabilization therapy and rehabilitation, 5 proteins were determined in the plasma: brainand glial-derived neurotrophic factors, neuron-specific enolase, alpha-synuclein and calcium-binding protein S100B. Statistical analysis of the data involved the Mann-Whitney test for comparing the values of the control and experimental groups and the Wilcoxon test for comparing the values of one group obtained at different stages of observation. The calculations were carried out using StatPlus version 7 (AnalystSoft Inc., USA).Results. A total of 31 patients were included in the main group, 18 of them were followed up with a diagnosis of opioid dependence syndrome (n = 11) or psychostimulant dependence syndrome (n = 7). Patients dropped out of the study due to their refusal to participate in the study or undergo rehabilitation, or due to relapse of the disease. When admitted to the hospital, patients indicated a 45% decrease in brain-derived neurotrophic factor in the plasma ( p < 0.001), and a 3.9-fold decrease after rehabilitation course ( p < 0.001). Glial-derived neurotrophic factor in the plasma exceeded the controls 1.9 times ( p < 0.001) upon admission to hospital, but rapidly returned to normal values thereafter. Level of neuron-specific enolase in the plasma was also poor, 36% lower than the controls ( p <0.001), but approached the control values by the end of rehabilitation.Conclusion. The study obtained data indicating the changes in neurotrophic factors in the blood plasma of patients with opioid or psychostimulant dependence. The rehabilitation period was marked by a relatively rapid improving level of neurotrophins; however, brain-derived neurotrophic factor remained reduced despite the successful treatment, which may indicate the irreversible changes.

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“…For this reason, mathematical modeling is one of the main modern methods for studying DNA molecular dynamics, its mechanical movements, open states, denaturation bubbles [ 5 , 6 , 7 ]. This method, despite several simplifications, allows us to consider various aspects of DNA functioning with great accuracy [ 8 , 9 , 10 ]. In the article [ 11 ], using a combination of atomic force microscopy (AFM) and modeling of atomic molecular dynamics (MD), an attempt was made to experimentally observe the dynamics of open states.…”

Section: Introductionmentioning

confidence: 99%

Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range

Басов

Drobotenko

Svidlov

et al. 2022

IJMS

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The effect of single substitutions of protium for deuterium in hydrogen bonds between pairs of nitrogenous bases on the open states occurrence probability at high critical breaking energies of these bonds has been studied. The study was carried out using numerical methods based on the angular mathematical model of DNA. The IFNA17 gene was divided into three approximately equal parts. A comparison of the open states occurrence probability in these parts of the gene was done. To improve the accuracy of the results, a special data processing algorithm was developed. The developed methods have shown their suitability for taking into account the occurrence of open states in the entire range of high critical energies. It has been established that single 2H/1H substitutions in certain nitrogenous bases can be a mechanism for maintaining the vital activity of IFNA17 under critical conditions. In general, the developed method of the mathematical modeling provide unprecedented insight into the DNA behavior under the highest critical energy range, which greatly expands scientific understanding of nucleobases interaction.

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DNA Dynamics under Periodic Force Effects

Cited by 18 publications

References 30 publications

The Effect of Electromagnetic Microwave Radiation on Methane Fermentation of Selected Energy Crop Species

The Effect of Electromagnetic Microwave Radiation on Methane Fermentation of Selected Energy Crop Species

Analysis of Protein Markers in Plasma of Patients with Drug Dependence Syndrome: Observational Clinical Study

Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range

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