DNA Framework-Encoded Mineralization of Calcium Phosphate

Liu, Xiaoguo; Jing, Xinxin; Pi, Li; Pan, Muchen; Liu, Zhuo; Dai, Xinpei; Lin, Jianping; Li, Qian; Wang, Fei; Yang, Sichun; Wang, Lihua; Fan, Chunhai

doi:10.1016/j.chempr.2019.12.003

Cited by 71 publications

(86 citation statements)

References 51 publications

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“…[9] Having the chemical properties of polyanions, DNA possesses the capacity to bind nonspecifically to calcium ions. [9,10] Although DNA has frequently been identified outside cells, [11][12][13][14] extracellular DNA has never been used for intrafibrillar collagen mineralization at the molecular level. [15,9] Here, we hypothesize that extracellular DNAs participate in intrafibrillar collagen mineralization.…”

Section: Introductionmentioning

confidence: 99%

Extracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization

et al. 2021

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Although deoxyribonucleic acid (DNA) is the genetic coding for the very essence of life, these macromolecules or components thereof are not necessarily lost after a cell dies. There appears to be a link between extracellular DNA and biomineralization. Here the authors demonstrate that extracellular DNA functions as an initiator of collagen intrafibrillar mineralization. This is confirmed with in vitro and in vivo biological mineralization models. Because of their polyanionic property, extracellular DNA molecules are capable of stabilizing supersaturated calcium phosphate solution and mineralizing 2D and 3D collagen matrices completely as early as 24 h. The effectiveness of extracellular DNA in biomineralization of collagen is attributed to the relatively stable formation of amorphous liquid droplets triggered by attraction of DNA to the collagen fibrils via hydrogen bonding. These findings suggest that extracellular DNA is biomimetically significant for fabricating inorganic-organic hybrid materials for tissue engineering. DNA-induced collagen intrafibrillar mineralization provides a clue to the pathogenesis of ectopic mineralization in different body tissues. The use of DNase for targeting extracellular DNA at destined tissue sites provides a potential solution for treatment of diseases associated with ectopic mineralization.

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Section: Introductionmentioning

confidence: 99%

Extracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization

et al. 2021

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“…[109][110][111][112] More recently, DNA origami nanostructures have been mineralised, giving access to exquisitely well-defined silica or calcium phosphate-coated nanostructures. [113][114][115] This complements the rich literature around the metallation of DNA nanostructures, which is by now a well-developed field. [116][117][118] DNA origami scaffolds have also been demonstrated to direct the assembly of lipids into structures that are not normally accessible, such as cuboids.…”

Section: [H2] Templated Assemblymentioning

confidence: 60%

Synthesis and applications of anisotropic nanoparticles with precisely defined dimensions

et al. 2020

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Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document.When citing, please reference the published version. Take down policyWhile the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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“…Of note, the softness inherited in these nanoparticles may play an important role in their delivery or cellular uptake 117 . The same group 118 also reported a FNAs-templated strategy for calcium phosphate (CaP) crystallization ( Fig. 4 C).…”

Section: Fnas For Drug Deliverymentioning

confidence: 93%

Pharmaceutical applications of framework nucleic acids

Liang

Zhang²,

Lin³

et al. 2022

Acta Pharmaceutica Sinica B

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DNA is a biological polymer that encodes and stores genetic information in all living organism. Particularly, the precise nucleobase pairing inside DNA is exploited for the self-assembling of nanostructures with defined size, shape and functionality. These DNA nanostructures are known as framework nucleic acids (FNAs) for their skeleton-like features. Recently, FNAs have been explored in various fields ranging from physics, chemistry to biology. In this review, we mainly focus on the recent progress of FNAs in a pharmaceutical perspective. We summarize the advantages and applications of FNAs for drug discovery, drug delivery and drug analysis. We further discuss the drawbacks of FNAs and provide an outlook on the pharmaceutical research direction of FNAs in the future.

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DNA Framework-Encoded Mineralization of Calcium Phosphate

Cited by 71 publications

References 51 publications

Extracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization

Extracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization

Synthesis and applications of anisotropic nanoparticles with precisely defined dimensions

Pharmaceutical applications of framework nucleic acids

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