DNA interactions and biocidal activity of metal complexes of benzothiazole Schiff bases: synthesis, characterization and validation

Vamsikrishna, Narendrula; Kumar, Manish; Ramesh, Gali; Ganji, Nirmala; Daravath, Sreenu; Shivaraj,

doi:10.1007/s12039-017-1273-7

Cited by 62 publications

(26 citation statements)

References 58 publications

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“…where ε a , ε f , and ε b correspond to A obsd /[complex], the extinction coefficient of free complex, and complex in the fully bound form, respectively. The K b values for complexes 1-6 are found 5.18×10 5 , 3.41×10 5 , 1.69×10 5 , 1.66×10 5 , 1.46×10 5 and 1.78×10 5 M -1 , respectively. The observed results show that complex 1 has the highest binding propensity with DNA, which can be attributed to the presence of most electronegative F atom as a substituent atom at p-po-sition to the ancillary ligand.…”

Section: Dna Interaction Study: Absorption Titrationmentioning

confidence: 91%

“…The interaction of coordination compounds with various biomolecules is facilitated due to varying oxidation states of central metal ion, which can eventually result in surprising pharmacological and exceptional curative properties. [4][5][6][7][8] Metals can alter the physiological condition and the intrinsic toxicity of metal ions can be reduced by their coordination with ligands. The biological properties of ligands can increase with metal chelation and can cause a synergistic effect on both ligand and metal ion.…”

Section: Introductionmentioning

confidence: 99%

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DNA Interaction, in vitro Antibacterial and Cytotoxic Activities of Ru(III) Heterochelates

Karia¹,

Vekariya²,

Patidar³

et al. 2019

ACSi

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Ruthenium(III) complexes [Ru(bphtpy)(PPh 3)Cl 3 ] (bphfpy = diphenylfuranylpyridine derivatives) were synthesized and characterized by LCMS, IR spectroscopy, elemental analysis and magnetic measurements. All the complexes were screened for their antibacterial activity in terms of minimum inhibitory concentration against two Gram-positive and three Gram-negative bacterial species. DNA binding study by absorption titration and viscosity measurement shows that complexes bind in an intercalating mode, which is also confirmed by molecular docking. All the complexes were also screened for the DNA nuclease property of pUC19 plasmid DNA. The cytotoxicity study of the synthesized complexes was performed to elucidate the LC 50 values to find out the toxicity profile of the complexes.

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Section: Dna Interaction Study: Absorption Titrationmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

DNA Interaction, in vitro Antibacterial and Cytotoxic Activities of Ru(III) Heterochelates

Karia¹,

Vekariya²,

Patidar³

et al. 2019

ACSi

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“…The new peaks of phenolic -OH protons of the aminophenol and aromatic protons were observed at δ10.0, 10.1 ppm, and δ6. 38,39 . The mass spectral data of Schiff base ligand and its copper (II) complex were confirmed by comparing their molecular formula weights with (m/z) mass values, which is in good agreement for these ligand and Cu complex as shown in Fig.…”

Section: Nmr Spectral Studiesmentioning

confidence: 99%

Untitled

2020

IJPSR

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The new asymmetrical tetradentate (ONNO) Schiff base (L) 4chloro-2-((E)-(4-((E)-((2-hydroxy-5-nitrophenyl)imino)methyl)benzylidene) amino)phenol was prepared by the condensation of terephthalaldehyde with 2amino 4-chlorophenol and 2-amino 4-nitrophenol in 1:1:1 molar ratio in methanol. The homo binuclear metal(II) complexes were synthesized in ligand to metal ratio 2:2 from the template method. The composition, geometry and binding sites of ligand and its complexes were determined by various studies like Elemental, molar conductance, electronic, magnetic moment, FT-IR, 1 H and 13 C-NMR, ESI-Mass, EPR, Thermal, and PXRD. The above spectral studies show that the Schiff is a dibasic tetradentate (ONNO), and its metal complexes possess a square planar structure. The biological applications of all compounds were tested for antibacterial, antioxidant, and DNA cleavage, and the final reports reveal high inhibition activity for metal(II) complexes compared to the ligand. The DNA binding activities of Cu(II) complex was observed by electronic absorption method. Antitumor activity of Cu(II) complex was screened for their cancer-inhibiting ability against MCF-7 human breast cancer cells by using the MTT experiment.

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“…Such resisting behavior of pathogens demands modification and diversification of these bioactive compounds to make them compatible with current needs . Metal‐based drugs are proving to be potential candidates to replace their traditionally used counterparts . This may be due to their higher yields with lower possibilities of isomer generation .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and biological screening of metal complexes of novel sulfonamide derivatives: Experimental and theoretical analysis of sulfonamide crystal

Sumrra

Hassan

Imran

et al. 2020

Applied Organom Chemis

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This study reports the synthesis of sulfonamide‐derived Schiff bases as ligands L1 and L2 as well as their transition metal complexes [VO(IV), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II)]. The Schiff bases (4‐{E‐[(2‐hydroxy‐3‐methoxyphenyl)methylidene]amino}benzene‐1‐sulfonamide (L1) and 4‐{[(2‐hydroxy‐3‐methoxyphenyl)methylidene]amino}‐N‐(5‐methyl‐1,2‐oxazol‐3‐yl)benzene‐1‐sulfonamide (L2) were synthesized by the condensation reaction of 4‐aminobenzene‐1‐sulfonamide and 4‐amino‐N‐(3‐methyl‐2,3‐dihydro‐1,2‐oxazol‐5‐yl)benzene‐1‐sulfonamide with 2‐hydroxy‐3‐methoxybenzaldehyde in an equimolar ratio. Sulfonamide core ligands behaved as bidentate ligands and coordinated with transition metals via nitrogen of azomethine and the oxygen of the hydroxyl group. Ligand L1 was recovered in its crystalline form and was analyzed by single‐crystal X‐ray diffraction technique which held monoclinic crystal system with space group (P21/c). The structures of the ligands L1and L2 and their transition metal complexes were established by their physical (melting point, color, yields, solubility, magnetic susceptibility, and conductance measurements), spectral (UV–visible [UV–Vis], Fourier transform infrared spectroscopy, 1H NMR, 13C NMR, and mass analysis), and analytical (CHN analysis) techniques. Furthermore, computational analysis (vibrational bands, frontier molecular orbitals (FMOs), and natural bonding orbitals [NBOs]) were performed for ligands through density functional theory utilizing B3LYP/6‐311+G(d,p) level and UV–Vis analysis was carried out by time‐dependent density functional theory. Theoretical spectroscopic data were in line with the experimental spectroscopic data. NBO analysis confirmed the extraordinary stability of the ligands in their conjugative interactions. Global reactivity parameters computed from the FMO energies indicated the ligands were bioactive by nature. These procedures ensured the charge transfer phenomenon for the ligands and reasonable relevance was established with experimental results. The synthesized compounds were screened for antimicrobial activities against bacterial (Streptococcus aureus, Bacillus subtilis, Eshcheria coli, and Klebsiella pneomoniae) species and fungal (Aspergillus niger and Aspergillus flavous) strains. A further assay was designed for screening of their antioxidant activities (2,2‐diphenyl‐1‐picrylhydrazine radical scavenging activity, total phenolic contents, and total iron reducing power) and enzyme inhibition properties (amylase, protease, acetylcholinesterase, and butyrylcholinesterase). The substantial results of these activities proved the ligands and their transition metal complexes to be bioactive in their nature.

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DNA interactions and biocidal activity of metal complexes of benzothiazole Schiff bases: synthesis, characterization and validation

Cited by 62 publications

References 58 publications

DNA Interaction, in vitro Antibacterial and Cytotoxic Activities of Ru(III) Heterochelates

DNA Interaction, in vitro Antibacterial and Cytotoxic Activities of Ru(III) Heterochelates

Untitled

Synthesis, characterization, and biological screening of metal complexes of novel sulfonamide derivatives: Experimental and theoretical analysis of sulfonamide crystal

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