DNA methylation in childhood dental caries and hypomineralization

MJ, Silva; Mohandas, Namitha; JM, Craig; Manton, David J.; Saffery, Richard; Southey, MC; Dp, Burgner; Lucas, Josette; Kilpatrick, NM; Hopper, JL; Scurrah, Katrina J; S, Li

doi:10.1016/j.jdent.2021.103913

Cited by 9 publications

(7 citation statements)

References 40 publications

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“…As is shown in the results, 19 DMCpGs were associated with HSPM. DMRs existed in genes associated with tooth development, such as Pbx1, ACAT2, ltbp3, and DDR1 (Mj et al, 2022). The methylation level of genes related to tooth development at birth is associated with the occurrence of HSPM in the future.…”

Section: Resultsmentioning

confidence: 99%

“…Perinatal and postnatal factors significantly connected with the etiology of MIH (Garot et al, 2022) (Mj et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Wojciech Tynior et al collected buccal mucosa swabs to test global DNA methylation levels (Tynior et al, 2022). And Silva MJ et al performed genome‐wide DNA methylation analysis collecting umbilical cord blood (Mj et al, 2022). Furthermore, histological evaluations in human teeth are encouraged to provide more convincing conclusions, which could not achieve due to ethical issues.…”

Section: Discussionmentioning

confidence: 99%

“…Tynior et al performed global DNA methylation examination in children and found that significant differences in global DNA methylation levels were connected with potential factors for MIH development (Tynior et al, 2022). In parallel, dental‐related differentially methylated CpGs and regions were proved to be associated with HSPM (Mj et al, 2022). We believe that with the in‐depth study of the epigenetic mechanism, novel detection method will be invented.…”

Section: Discussionmentioning

confidence: 99%

“…A latest study showed that significant differences in global DNA methylation levels were connected with five potential factors for MIH development (Tynior et al, 2022). Hypomineralized Second Primary Molars (HSPM), a type of DDE which can easily turn into early child caries, was proved to have connection with the methylation level of tooth‐development‐related genes at birth (Mj et al, 2022). Our previous study has revealed that Ezh2‐mediated trimethylated histone 3 lysine 27 (H3K27me3), a histone modification, function as a critical regulator for mouse incisor epithelial stem cell fate, enamel homeostasis, and injury repair (Yu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Epigenetics in developmental defects of enamel: A scoping review

Zhang

Cui

et al. 2023

Oral Diseases

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ObjectivesThe significant role of epigenetics has been revealed in normal enamel formation process and occurrence of developmental defects. This presented literature is aiming at summarizing the regulatory function of epigenetics in physiological amelogenesis process and reviewing the epigenetic mechanisms in occurrence of developmental defects of enamel (DDE), so as to provide biological foundation evidence to support early predication and clinical management of DDE.MethodAn extensive literature review was conducted using electronic databases MEDLINE (through PubMed), Web of Science and EMBASE up to November 30, 2022. Studies about epigenetic effects on enamel tissue or cells associated with amelogenesis, including in vivo studies using human or animal models, and in vitro studies, are selected.ResultsA total of 22 studies were included. Epigenetic factors or effects specifically activate or silence certain genes, which may regulate related biological activities including cell proliferation, cell differentiation, enamel secretion, and mineralization during the process of amelogenesis. Once the status of epigenetic modification is altered, the quantity and quality of enamel may both be disturbed, which can finally result in DDE.ConclusionEpigenetics plays a noteworthy role of regulating the amelogenesis process and DDE potentially by altering the expression levels of genes related to enamel formation, providing a new perspective of early predication and clinical management of DDE.

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Section: Resultsmentioning

confidence: 99%

“…Perinatal and postnatal factors significantly connected with the etiology of MIH (Garot et al, 2022) (Mj et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Epigenetics in developmental defects of enamel: A scoping review

Zhang

Cui

et al. 2023

Oral Diseases

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Prevalence of and factors associated with molar-incisor hypomineralisation in schoolchildren in the canton of Basel-Landschaft, Switzerland

et al. 2022

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Objectives As prevalence of molar-incisor hypomineralisation varies considerably in different countries and regions, the aim of this study was to obtain representative epidemiological data for schoolchildren living in the canton of Basel-Landschaft, Switzerland. Material and methods A representative population of schoolchildren of three different age groups, i.e. 1st grade (mean age: 7.4 years), 6th grade (mean age: 12.6 years), and 9th grade (mean age: 15.7 years) visiting compulsory schools in the canton of Basel-Landschaft, Switzerland, was examined. The presence or absence of molar-incisor hypomineralisation at time of examination was recorded as well as potential influencing factors such as age group, gender, nationality, or the children’s place of residence. Results A total of 1252 schoolchildren could be included. On average, the prevalence of MIH in the study population was 14.8%. No statistically significant differences were found for nationality, gender, or place of residence. Although not statistically significant, children from the youngest age group had the highest while children from the oldest age group had the lowest MIH prevalence. Conclusion With a mean value of 14.8%, MIH prevalence among schoolchildren living in the canton of Basel-Landschaft, Switzerland, is comparable to mean values recorded globally. Clinical relevance This study represents the first study on MIH prevalence in Switzerland and also provides further evidence on potential influencing factors.

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