DNA methylation in white blood cells

Terry, Mary Beth; Delgado‐Cruzata, Lissette; Vin-Raviv, Neomi; Wu, Hui; Santella, Regina M.

doi:10.4161/epi.6.7.16500

Cited by 298 publications

(165 citation statements)

References 95 publications

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“…Most studies, however, do not support an age-dependent effect of WBC LINE-1 methylation. 25 In this young population (mean age = 29.4 y), we did not find a significant association between age and WBC LINE-1 methylation. Because the study population is relatively young, the lack of an age-dependent effect of LINE-1 methylation could be due to the overall young age.…”

Section: Discussioncontrasting

confidence: 60%

“…Others suggested that age may only account for a small proportion of the inter-individual variation of global methylation in humans. 25 Several studies documented a significantly lower level of LINE-1 methylation in women than in men. 25 Some suggested that women may have a higher folate requirement than men due to regular loss of red blood cells through menstruation.…”

Section: Discussionmentioning

confidence: 99%

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White blood cell global methylation and IL-6 promoter methylation in association with diet and lifestyle risk factors in a cancer-free population

et al. 2012

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Keywords: DNA methylation, diet, lifestyle factors, cancer As aberrant DNA methylation is associated with cancer and other human diseases, there are growing interests in determining how environmental exposures may affect patterns of DNA methylation. Previous studies found older monozygotic twins were more diverse in DNA methylation patterns than were younger monozygotic twins.17 There is also evidence that DNA methylation patterns in individuals change over time, 18 supporting aging and/or external environment factors affecting DNA methylation. However, which environmental exposures, among many that individuals are exposed to over the life course, affect patterns of DNA methylation remains elusive.Chronic inflammation constitutes an important mechanism for cancer. 19 The specific pathways by which inflammation causes cancer are not fully understood. Interleukin (IL-6) is a proinflammatory cytokine released by inflammatory cells and can activate intracellular transcription factors leading to tumorigenesis. There are some suggestions that IL-6 may stimulate tumor proliferation by altering patterns of DNA methylation, 20-22 and

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

White blood cell global methylation and IL-6 promoter methylation in association with diet and lifestyle risk factors in a cancer-free population

et al. 2012

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“…Individuals undergo extensive changes in DNA methylation patterns during their lifespan, in accordance with the changes in their tissue-specific gene expression patterns related to aging and other physiologic states. 37 It is well established that alterations in DNA methylation represent early events in carcinogenesis, [1][2][3][4][5][6][7][8]24 characterized by genome-wide hypomethylation, especially at repetitive elements throughout the genome, such as LINE-1, and gene-specific promoter hypermethylation, which affects expression of tumor suppressor genes. 1-6, 25,35, 38 Histologically normal tissues are known to maintain a high percent methylation of LINE-1 (ranging from approximately 7585%-).…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19] Genome-wide DNA methylation (e.g., measured in repetitive sequences including, Alu, Sat2, and LINE-1) in white blood cells (WBCs) has been shown to be associated with age, gender, race, alcohol exposure, and family history of breast cancer. [20][21][22][23][24] Additionally, compared to histologically normal or normal-appearing tissues (adjacent to breast tumors), tumor tissues consistently have lower levels of DNA methylation (i.e., increased hypomethylation throughout the genome), even early in breast carcinogenesis. 4,5,25 Furthermore, there are reports of significant associations between LINE-1 methylation and breast tumor clinicopathological features, 3 as well as breast cancer prognosis.…”

Section: Introductionmentioning

confidence: 99%

Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues

Llanos

Marian²,

Brasky

et al. 2015

Epigenetics

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Genome-wide DNA hypomethylation is an early event in the carcinogenic process. Percent methylation of long interspersed nucleotide element-1 (LINE-1) is a biomarker of genome-wide methylation and is a potential biomarker for breast cancer. Understanding factors associated with percent LINE-1 DNA methylation in histologically normal tissues could provide insight into early stages of carcinogenesis. In a cross-sectional study of 121 healthy women with no prior history of cancer who underwent reduction mammoplasty, we examined associations between plasma and breast folate, genetic variation in one-carbon metabolism, and percent LINE-1 methylation using multivariable regression models (adjusting for race, oral contraceptive use, and alcohol use). Results are expressed as the ratio of LINE-1 methylation relative to that of the referent group, with the corresponding 95% confidence intervals (CI). We found no significant associations between plasma or breast folate and percent LINE-1 methylation. Variation in MTHFR, MTR, and MTRR were significantly associated with percent LINE-1 methylation. Variant allele carriers of MTHFR A1289C had 4% lower LINE-1 methylation (Ratio 0.96, 95% CI 0.93-0.98), while variant allele carriers of MTR A2756G (Ratio 1.03, 95% CI 1.01-1.06) and MTRR A66G (Ratio 1.03, 95% CI 1.01-1.06) had 3% higher LINE-1 methylation, compared to those carrying the more common genotypes of these SNPs. DNA methylation of LINE-1 elements in histologically normal breast tissues is influenced by polymorphisms in genes in the one-carbon metabolism pathway. Future studies are needed to investigate the sociodemographic, environmental and additional genetic determinants of DNA methylation in breast tissues and the impact on breast cancer susceptibility.

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“…Many studies have found that LINE-1 methylation was higher in males than in females (reviewed in ref. 50). We found males had lower Sat2 methylation than females.…”

Section: Discussionmentioning

confidence: 99%

Global DNA methylation in a population with aflatoxin B₁exposure

Qiao

Yang

et al. 2013

Epigenetics

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DNA methylation in white blood cells

Cited by 298 publications

References 95 publications

White blood cell global methylation and IL-6 promoter methylation in association with diet and lifestyle risk factors in a cancer-free population

White blood cell global methylation and IL-6 promoter methylation in association with diet and lifestyle risk factors in a cancer-free population

Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues

Global DNA methylation in a population with aflatoxin B₁exposure

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DNA methylation in white blood cells

Cited by 298 publications

References 95 publications

White blood cell global methylation and IL-6 promoter methylation in association with diet and lifestyle risk factors in a cancer-free population

White blood cell global methylation and IL-6 promoter methylation in association with diet and lifestyle risk factors in a cancer-free population

Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues

Global DNA methylation in a population with aflatoxin B1exposure

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Product

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Global DNA methylation in a population with aflatoxin B₁exposure