“…In fact, changes in DNA methylation (DNAm), non-coding RNAs, and histone tail modifications have all been shown to be associated with human environmental exposures across a wide range of domains including toxicant, social/behavioral, diet, and pharmacologic. DNA methylation has been shown to undergo both losses and gains in global and/or repetitive elements with exposure to metals [1][2][3], benzene [4], persistent organic pollutants [5,6], particulate matter [7,8], mycotoxin [9], endocrine-disrupting chemicals [10], lifestyle factors [11,12], and inorganic arsenic [13,14]. In addition, locus-specific differences in DNAm associated with exposure to nutrition [15][16][17], inorganic arsenic [18,19], medications [20,21], childhood abuse [22] and stress [23], socioeconomic status [24,25], tobacco [26-32, 33•, 34, 35•, 36], polycyclic aromatic hydrocarbons [37,38], infections [39,40], and endocrine-disrupting chemicals [41,42] have also been observed.…”