2012
DOI: 10.1016/j.jmoldx.2012.07.001
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DNA Methylation Index and Methylation Profile of Invasive Ductal Breast Tumors

Abstract: Breast carcinogenesis is a multistep process that involves both genetic and epigenetic alterations. Identification of aberrantly methylated genes in breast tumors and their relation to clinical parameters can contribute to improved diagnostic, prognostic, and therapeutic decision making. Our objective in the present study was to identify the methylation status of 34 cancer-involved genes in invasive ductal carcinomas (IDC). Each of the 70 IDC cases analyzed had a unique methylation profile. The highest methyla… Show more

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Cited by 32 publications
(38 citation statements)
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“…In addition, within patient subgroups that share the same tumor type, one finds differences in morbidity and mortality. It has been proposed that each tumor presents a unique epigenetic signature [11]. Thus, the differences are not only restricted to occur between populations of different geographic regions, but also among individuals of the same population, which supports the validity of the new paradigm of individualized medicine.…”
Section: Role Of Dna Methylation In Breast Cancer Heterogeneitymentioning
confidence: 88%
See 3 more Smart Citations
“…In addition, within patient subgroups that share the same tumor type, one finds differences in morbidity and mortality. It has been proposed that each tumor presents a unique epigenetic signature [11]. Thus, the differences are not only restricted to occur between populations of different geographic regions, but also among individuals of the same population, which supports the validity of the new paradigm of individualized medicine.…”
Section: Role Of Dna Methylation In Breast Cancer Heterogeneitymentioning
confidence: 88%
“…However, some controversial observations have appeared regarding the observed methylation frequencies in distinct genes and their transcriptional impact. When considering breast cancer, for example, some authors report methylation [11,21] with reduced expression of WT1 [21], while others communicate overexpression of this gene in the same tumor types [22]. Interestingly, some publications indicate methylation frequencies in this gene, which are highly different from those communicated by authors in other geographical regions [23].…”
Section: Why Is There Controversial Information About Dna Methylationmentioning
confidence: 99%
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“…In developing countries including Iran, patients diagnosed with breast cancer are 10 years younger compared to those in developed countries [3]. Both genetic and epigenetic changes are involved in the individual susceptibility to breast cancer [5]. Epigenetic modifications alter gene expression through DNA hypermethylation, histone modification, and microRNA mechanisms [6].…”
Section: Introductionmentioning
confidence: 99%