DNA Repair Gene ERCC1 and ERCC2/XPD Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck

Sturgis, Erich M.; Dahlstrom, Kristina R.; Spitz, Margaret R.; Wei, Qingyi

doi:10.1001/archotol.128.9.1084

Cited by 103 publications

(75 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, this is the first study to examine these associations for breast cancer, but other studies have supported an association between ERCC1 genotype and risk of adult glioma (24) and head and neck cancer (25). This polymorphism located within the 3 ¶-untranslated region of the ERCC1 gene may affect mRNA stability and alter mRNA levels (24).…”

Section: Discussionmentioning

confidence: 87%

“…The five single nucleotide polymorphisms (SNP) included ERCC1 (3 ¶-untranslated region 8092C/A, rs3212986), XPA (5 ¶-untranslated region À4A/G at position À4 from the ATG start codon, rs1800975), XPD (Asp-to-Asn substitution in codon 312 of exon 10, rs1799793), XPF (Arg-toGln substitution in codon 415 of exon 8, rs1800067), and XPG (Asp-to-His substitution in codon 1104 of exon 15, rs17655). Evidence from recent reports suggests that these genetic polymorphisms alter DNA repair capacity and contribute to cancer susceptibility (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). We hypothesized that those with suboptimal DNA repair, as characterized by genotype, would have a greater breast cancer risk due to increased PAH-DNA adduct levels.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polymorphisms in Nucleotide Excision Repair Genes, Polycyclic Aromatic Hydrocarbon-DNA Adducts, and Breast Cancer Risk

Crew

Gammon

Terry

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Genes involved in the nucleotide excision repair (NER) pathway, which removes bulky DNA adducts, are potential low-penetrance cancer susceptibility genes. We recently reported an association between detectable polycyclic aromatic hydrocarbon (PAH)-DNA adducts and breast cancer risk. Using a population-based breast cancer case-control study on Long Island, New York, we examined whether polymorphisms in NER genes modified the association between PAH-DNA adducts and breast cancer risk. We examined polymorphisms in ERCC1 (3 ¶-untranslated region 8092C/A), XPA (5 ¶-untranslated region À4G/A), XPD (Asp 312 Asn in exon 10), XPF (Arg 415 Gln in exon 8), and XPG (Asp 1104 His in exon 15) in 1,053 breast cancer cases and 1,102 population-based controls. The presence of at least one variant allele in XPD was associated with a 25% increase in the odds ratio [OR, 1.25; 95% confidence interval (95% CI), 1.04-1.50] for breast cancer. The increase associated with homozygosity of the variant alleles for XPD and ERCC1 was stronger among those with detectable PAH-DNA adduct levels (OR, 1.83; 95% CI, 1.22-2.76 and OR, 1.92; 95% CI, 1.14-3.25 for detectable versus nondetectable adducts and homozygous wild-type genotype for XPD and ERCC1, respectively). We found no association between XPA, XPF, and XPG genotypes, PAH-DNA adducts, and breast cancer risk. When we combined genotypes for these NER pathway genes, there was a significant trend for increasing breast cancer risk with increasing number of putative high-risk alleles. Overall, this study suggests that the risk of breast cancer may be elevated among women with polymorphisms in NER pathway genes and detectable PAH-DNA adducts. (Cancer Epidemiol Biomarkers Prev 2007;16(10):2033 -41)

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Polymorphisms in Nucleotide Excision Repair Genes, Polycyclic Aromatic Hydrocarbon-DNA Adducts, and Breast Cancer Risk

Crew

Gammon

Terry

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…There are two described polymorphisms that induce amino acid changes in the protein: at codons 312 (Asp to Asn) and 751 (Lys to Gln) (87)(88)(89). To date, these two polymorphisms have been extensively studied (87,88,(90)(91)(92)(93)(94)(95).…”

Section: Genetic Polymorphisms In Genes Involved In Ner Pathway and Rmentioning

confidence: 99%

DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population

Long¹,

Yao²,

Zeng³

et al. 2011

DNA Repair

View full text Add to dashboard Cite

“…We have reported a significant association between polymorphisms in exons 6, 22 and 23 of the XPD gene and melanoma in patients under 50 (Tomescu et al, 2001). Significant association between NER gene polymorphisms and other cancers, but not colorectal, have also been reported: glioma (Chen et al, 2000); lung (Chen et al, 2002;Park et al, 2002); squamous cell carcinoma of the head and neck (SCCHN; Sturgis et al, 2002).…”

mentioning

confidence: 99%

Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer

et al. 2003

View full text Add to dashboard Cite

DNA Repair Gene ERCC1 and ERCC2/XPD Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck

Abstract: These 2 polymorphisms may contribute to the risk of SCCHN, but larger studies are needed to confirm their role in SCCHN. Combining common DNA repair gene polymorphisms into models of genetic risk of SCCHN may improve risk estimates.

Cited by 103 publications

References 8 publications

Polymorphisms in Nucleotide Excision Repair Genes, Polycyclic Aromatic Hydrocarbon-DNA Adducts, and Breast Cancer Risk

Polymorphisms in Nucleotide Excision Repair Genes, Polycyclic Aromatic Hydrocarbon-DNA Adducts, and Breast Cancer Risk

DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population

Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer

Contact Info

Product

Resources

About