DNA replication in Escherichia coli: Physical and kinetic studies of the replication point

Dingman, C. Wesley; Fisher, Matthew; Ishizawa, Masaki

doi:10.1016/0022-2836(74)90585-3

Cited by 20 publications

(2 citation statements)

References 17 publications

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“…Since then discontinuous DNA synthesis has been repeatedly demonstrated in bacteria (Okazaki et al, 19 68a, b;Yudelevich et al , 1968;Geider & Hoffman-Berling, 1971;Wang & Sternglanz, 1972;Dingman et al, 1974) and in phage (Sadowski et al, 1968;Polsinelli et al J 1969;, and eviden ce was obtaine d showing that all the Okazaki pieces are made in the 5 1 ----+3' direction . Only Werner and coworkers disagree with this scheme, claiming that Okazaki fragments are made through a process of random 11 crystallization" of nucleotides on the parental template rather than sequentially in a 51~31 direction (Diaz et a1., 1975;Diaz & Werner, 1975).…”

Section: Okazaki Fragmentsmentioning

confidence: 96%

Discontinuous DNA Synthesis in Mammalian Cells

Huberman¹,

Horwitz²

1974

Cold Spring Harbor Symposia on Quantitative Biology

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Section: Okazaki Fragmentsmentioning

confidence: 96%

Discontinuous DNA Synthesis in Mammalian Cells

Huberman¹,

Horwitz²

1974

Cold Spring Harbor Symposia on Quantitative Biology

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“…Colocalization of the DNA polymerases from the two forks originating from a single initiation event was initially proposed by Dingman et al (1974). Other authors suggested that forks are paired for a time and then move in opposite directions (Bates & Kleckner, 2005; Hiraga et al , 1998; Reyes-Lamothe et al , 2010).…”

Section: Introductionmentioning

confidence: 99%

Organization of ribonucleoside diphosphate reductase during multifork chromosome replication in Escherichia coli

2011

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Ribonucleoside diphosphate reductase (RNR) is located in discrete foci in a number that increases with the overlapping of replication cycles in Escherichia coli. Comparison of the numbers of RNR, DnaX and SeqA protein foci with the number of replication forks at different growth rates reveals that fork : focus ratios augment with increasing growth rates, suggesting a higher cohesion of the three protein foci with increasing number of forks per cell. Quantification of NrdB and SeqA proteins per cell showed: (i) a higher amount of RNR per focus at faster growth rates, which sustains the higher cohesion of RNR foci with higher numbers of forks per cell; and (ii) an equivalent amount of RNR per replication fork, independent of the number of the latter.

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Thymidine Metabolism in Bacteria (and “How, or How Not, to Label DNA”)

O’Donovan

1978

DNA Synthesis

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DNA replication in Escherichia coli: Physical and kinetic studies of the replication point

Cited by 20 publications

References 17 publications

Discontinuous DNA Synthesis in Mammalian Cells

Discontinuous DNA Synthesis in Mammalian Cells

Organization of ribonucleoside diphosphate reductase during multifork chromosome replication in Escherichia coli

Thymidine Metabolism in Bacteria (and “How, or How Not, to Label DNA”)

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