DNA-templated copper nanoparticles as signalling probe for electrochemical determination of microRNA-222

Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications

“…Poly(thymine)-CuNCs as a fluorometric probe were able to detect miRNA with LOD of 44 fM 341. Zhihui Dai and co-workers81 and Yuzhong Zhang and co-workers345 prepared miRNA sensors based on the electrocatalytic property of DNAtemplated CuNCs with LOD values of 8.2 fM and 0.03 fM, respectively. Furthermore, the detection sensitivity of various miRNAs has been improved by several orders of magnitude to the aM range with LODs from 36 aM 344 to 19.05 aM338 and as low as 10 aM 340 with a wide analytical performance range.…”

Ultrasensitive electrochemical sensing platform for miRNA-21 detection based on manganese dioxide-gold nanoparticle nanoconjugates coupled with hybridization chain reaction and horseradish peroxidase signal amplification

“…To detect low abundance of miRNAs, various biomagnification strategies have been employed to fabricate highly sensitive electrochemical biosensors, including loop-mediated isothermal amplification, 12 catalytic hairpin assembly, 13 strand-displacement amplification, 14,15 rolling circle amplification, 16,17 and hybridization chain reaction (HCR). 18,19 Among them, HCR has been widely employed 20–22 due to the advantages of gentle experimental conditions and high amplification efficiency.…”

Stochastic Collision Electrochemistry from Single Pt Nanoparticles: Electrocatalytic Amplification and MicroRNA Sensing

“…miRNAs are small noncoding RNAs, usually containing 17–26 nucleotides, which can control various biological processes. − Previous studies have shown that the abnormal expression of miRNAs is related to the development of diseases, some of which may be pathogenic factors for tumorigenesis. − For example, the increase in the level of miRNA21 in serum is related to breast, liver, and stomach. , Growing evidences show the carcinogenic effect of miRNA21 in inhibiting tumor cell apoptosis and promoting cancer growth, and it has been proposed as a potential biomarker for breast cancer diagnosis. − …”

“…32−35 For example, the increase in the level of miRNA21 in serum is related to breast, liver, and stomach. 36,37 Growing evidences show the carcinogenic effect of miRNA21 in inhibiting tumor cell apoptosis and promoting cancer growth, and it has been proposed as a potential biomarker for breast cancer diagnosis. 38−41 In this work, we designed a biosensing strategy based on PtNP collisions for the detection of miRNA with high selectivity and sensitivity.…”