DNA-templated in situ growth of AgNPs on SWNTs: a new approach for highly sensitive SERS assay of microRNA

Zheng, Jing; Bai, Junhui; Zhou, Qifeng; Li, Jishan; Li, Yinhui; Yang, Jinfeng; Yang, Ronghua

doi:10.1039/c5cc01003a

Cited by 41 publications

(19 citation statements)

References 13 publications

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“…As a typical layered carbon-based 1D nanomaterial, carbon nanotubes exhibit stable and excellent optical properties, as well as distinctive Raman scattering features that are induced from the chemical enhancement. In a previous study, Zheng et al [79] found that single-walled carbon nanotubes (SWNTs) can be bundled with ssDNA molecules to form a SERS-active SWNTs/DNA/Ag complex after reducing silver ions to silver nanoparticles on the surface (Figure 3C). The SERS signal intensity, jointly attributed to chemical and plasmonic enhancement, showed a positive correlation with the number of ssDNA aptamers for miR-21; the limit of detection (LOD) was 10 pM.…”

Section: D Nanostructuresmentioning

confidence: 99%

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Dimensional Surface‐Enhanced Raman Scattering Nanostructures for MicroRNA Profiling

Li¹,

Li²,

Qu³

et al. 2021

Small Structures

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Surface-enhanced Raman scattering (SERS) spectrum is an ultrasensitive quantitative tool for molecular fingerprinting and is very suitable for the analyzing and detecting trace substances, including low-abundance miRNAs. Researchers have already investigated the effects of nanomaterial-based SERS profiling on miRNA. As review herein, these SERS-active nanostructures can be generally classified into 0D, 1D, 2D, and 3D nanostructures according to their distinct structure. These SERS-active structures with differential structural dimensions exhibit differences in terms of detection performance which can be attributed to the unique nanomaterials involved and the overall design of the SERS nanostructures. In this review the authors focus on the design of SERS nanostructures in previous research, the advantages and disadvantages in miRNA profiling of the different dimensional nanostructures are analyzed, and some design principles to develop guidelines, to fabricate more effective SERS nano-sensors with ultra-high sensitivity and high levels accuracy are summarized, thereby promoting the practical application of miRNA profiling by SERS technology in complex life systems.

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Section: D Nanostructuresmentioning

confidence: 99%

Section: D Nanostructuresmentioning

confidence: 99%

Dimensional Surface‐Enhanced Raman Scattering Nanostructures for MicroRNA Profiling

Li¹,

Li²,

Qu³

et al. 2021

Small Structures

View full text Add to dashboard Cite

show abstract

“…By using NP‐CNMs, a system that functioned not only as an electrical biosensor but also a SERS‐based optical sensor was developed. Zheng et al conducted mRNA detection by using AgNP‐CNTs via a SERS‐based biosensor . In this study, single‐stranded DNA was introduced onto CNTs to conjugate Ag NPs on the CNT and prepare a SERS‐active substrate.…”

Section: Nanoparticle‐functionalized Cnts and Grp‐based Electrical Anmentioning

confidence: 99%

High‐Performance Biosensing Systems Based on Various Nanomaterials as Signal Transducers

Lee

Adegoke

Park

2018

Biotechnology Journal

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Recently, highly sensitive and selective biosensors have become necessary for improving public health and well-being. To fulfill this need, high-performance biosensing systems based on various nanomaterials, such as nanoparticles, carbon nanomaterials, and hybrid nanomaterials, are developed. Numerous nanomaterials show excellent physical properties, including plasmonic, magnetic, catalytic, mechanical and fluorescence properties and high electrical conductivities, and these unique and beneficial properties have contributed to the fabrication of high-performance biosensors with various applications, including in optical, electrical, and electrochemical detection platforms. In addition, these properties can be transformed to signals for the detection of biomolecules. In this review, various types of nanomaterial-based biosensors are introduced, and they show high sensitivity and selectivity. In addition, the potential applications of these sensors on the biosensing of several types of biomolecules are also discussed. These nanomaterials-based biosensing systems provide a significant improvement on healthcare including rapid monitoring and early detection of infectious disease for public health.

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“…For label-free detection, a variety of SERS-active substrates were designed to improve the Raman enhancement factor, such as hollow Au nanoflowers substrates [ 74 ], silver nanorod array substrates [ 75 ] and SWNTs@AgNPs [ 76 ]. Zheng et al [ 76 ] developed an approach of DNA-templated in situ growth of AgNPs on SWNTs for the sensitive detection of a potential cancer marker miRNA-21. The silica microbeads-conjugated double stranded DNA competitively bound to the target miRNA, forming liberated ssDNA that showed high affinity to SWNTs.…”

Section: Application On the Detection Of Human And Animal Originalmentioning

confidence: 99%

Analysis of Biomolecules Based on the Surface Enhanced Raman Spectroscopy

Jia

Zang

et al. 2018

Nanomaterials

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Analyzing biomolecules is essential for disease diagnostics, food safety inspection, environmental monitoring and pharmaceutical development. Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for detecting biomolecules due to its high sensitivity, rapidness and specificity in identifying molecular structures. This review focuses on the SERS analysis of biomolecules originated from humans, animals, plants and microorganisms, combined with nanomaterials as SERS substrates and nanotags. Recent advances in SERS detection of target molecules were summarized with different detection strategies including label-free and label-mediated types. This comprehensive and critical summary of SERS analysis of biomolecules might help researchers from different scientific backgrounds spark new ideas and proposals.

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DNA-templated in situ growth of AgNPs on SWNTs: a new approach for highly sensitive SERS assay of microRNA

Cited by 41 publications

References 13 publications

Dimensional Surface‐Enhanced Raman Scattering Nanostructures for MicroRNA Profiling

Dimensional Surface‐Enhanced Raman Scattering Nanostructures for MicroRNA Profiling

High‐Performance Biosensing Systems Based on Various Nanomaterials as Signal Transducers

Analysis of Biomolecules Based on the Surface Enhanced Raman Spectroscopy

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