DNA tile self-assembly driven by antibody-mediated four-way branch migration

Abstract

With the rapid development of DNA nanotechnology, the reasonable construction and precise control of complex DNA nanostructures have become active research areas. The effective combination of proteins and other biomacromolecules...

A nicking enzyme-assisted allosteric strategy for self-resetting DNA switching circuits

“…In the future design, we will continue our research based on the reusability and parallel information processing capability of self-resetting DNA switching circuits to explore multi-signal detection technologies in actual biological samples. In addition, we will further combine the selective function of self-resetting DNA switches with selfassembled structures 47,48 and macromolecular proteins such as antibodies 49,50 to provide programmable tools for building intelligent nanomachines, highly specific drug delivery systems, and multi-signal detection and reusable biosensors.…”

A DNA Finite-State Machine Based on the Programmable Allosteric Strategy of DNAzyme

“…In addition, more reliable ways can be explored to reduce the crosstalk between the biochemical signals, such as antibody-mediated DNA strand displacement, rather than only single-stranded DNA molecules for signal transduction. In future work, this programmable DNA finite-state machine with the sequential input of response time will be further studied to assist and control the self-assembly of complex structures [ 51 ], which will provide vital programmable control tools for building complex molecular machines. It is also possible to configure suitable binding sequences to design the activator as aptamers [ 52 ] or other biological signals [ 53 ] for the control of temporal information such as drug release.…”