DNA-triangular silver nanoparticles nanoprobe for the detection of dengue virus distinguishing serotype

Saranya, V.; Paramasivan, R; Mukherjee, Amitava; Chandrasekaran, Natarajan

doi:10.1016/j.saa.2018.05.047

Cited by 21 publications

(13 citation statements)

References 12 publications

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“…The sensitivity found by optical sensor in contact with DENV is 39.96 • nM −1 (Omar et al, 2018). Vinayagam et al (2018) reported the recognition of serotype-specific DENV employing multicolor triangular silver nanoparticles (TAg), which has the potential to be a powerful diagnosis technique that is able to differentiate between various serotypes. The color responses were established on the interaction of a TAg-DNA probe with a specific strand, resulting in the creation of a network association between the DNA probe and the dengue virus RNA, according to serotype.…”

Section: Biosensorsmentioning

confidence: 99%

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Recent Developments in Nanotechnology for Detection and Control of Aedes aegypti-Borne Diseases

Campos

Oliveira

Abrantes

et al. 2020

Front. Bioeng. Biotechnol.

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Arboviruses such as yellow fever, dengue, chikungunya and zika are transmitted mainly by the mosquito vector Aedes aegypti. Especially in the tropics, inefficacy of mosquito control causes arboviruses outbreaks every year, affecting the general population with debilitating effects in infected individuals. Several strategies have been tried to control the proliferation of A. aegypti using physical, biological, and chemical control measures. Other methods are currently under research and development, amongst which the use of nanotechnology has attracted a lot of attention of the researchers in relation to the production of more effective repellents and larvicides with less toxicity, and development of rapid sensors for the detection of virus infections. In this review, the utilization of nano-based formulations on control and diagnosis of mosquito-borne diseases were discussed. We also emphasizes the need for future research for broad commercialization of nano-based formulations in world market aiming a positive impact on public health.

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Section: Biosensorsmentioning

confidence: 99%

“…This was the first report of DNA conjugated to triangular silver nanoparticles, based on the pH reduction method. This biosensor has not yet been tested using real samples from infected patients, although the proposed technology appears to be very promising for use in clinical POC diagnostic testing (Vinayagam et al, 2018).…”

Section: Biosensorsmentioning

confidence: 99%

Recent Developments in Nanotechnology for Detection and Control of Aedes aegypti-Borne Diseases

Campos

Oliveira

Abrantes

et al. 2020

Front. Bioeng. Biotechnol.

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“…Among the various NPs currently being used for consumer products and biomedical applications, silver NPs (AgNPs) are widely tested for the development of therapeutic interventions and medical diagnosis as drug carriers, [37] nanoprobes, [38] bioimaging, [39] and labeling agents [40] due to their antibacterial properties and tunable surface plasmon resonance, although it has not been approved for medical purposes yet. At the same time, extensive studies have been conducted on the adverse biological effects of AgNPs, such as ROS generation, mitochondrial injury, DNA damage cell-cycle arrest, and apoptosis induction.…”

Section: Introductionmentioning

confidence: 99%

Mass Cytometry and Single‐Cell RNA‐seq Profiling of the Heterogeneity in Human Peripheral Blood Mononuclear Cells Interacting with Silver Nanoparticles

Kwon

Choi

et al. 2020

Small

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Understanding the interactions between nanoparticles (NPs) and human immune cells is necessary for justifying their utilization in consumer products and biomedical applications. However, conventional assays may be insufficient in describing the complexity and heterogeneity of cell–NP interactions. Herein, mass cytometry and single‐cell RNA‐sequencing (scRNA‐seq) are complementarily used to investigate the heterogeneous interactions between silver nanoparticles (AgNPs) and primary immune cells. Mass cytometry reveals the heterogeneous biodistribution of the positively charged polyethylenimine‐coated AgNPs in various cell types and finds that monocytes and B cells have higher association with the AgNPs than other populations. scRNA‐seq data of these two cell types demonstrate that each type has distinct responses to AgNP treatment: NRF2‐mediated oxidative stress is confined to B cells, whereas monocytes show Fcγ‐mediated phagocytosis. Besides the between‐population heterogeneity, analysis of single‐cell dose–response relationships further reveals within‐population diversity for the B cells and naïve CD4+ T cells. Distinct subsets having different levels of cellular responses with respect to their cellular AgNP doses are found. This study demonstrates that the complementary use of mass cytometry and scRNA‐seq is helpful for gaining in‐depth knowledge on the heterogeneous interactions between immune cells and NPs and can be incorporated into future toxicity assessments of nanomaterials.

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“…Another domain of interest for nanotechnologies in virology addresses the detection of viruses and the related setup of diagnostic tests. An example concerns the use of silver (Ag) NPs associated to DNA strands for the detection of the Dengue virus, via a colorimetric detection process, and high sensitivity was reported to detect different Dengue serotype RNAs [11]. Iron oxide nanoparticles of several compositions have also been used for virus detection purposes, among other nanosystems, as illustrated in the case of the Zika virus, exploiting a magnetic relaxation mechanism [12].…”

Section: Detection and Diagnosticsmentioning

confidence: 99%

Nanotechnologies: A Key Role in Virus Fight

Drouet¹

2020

BJSTR

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Zika, Ebola, Covid-19… Viruses from their nanoworld are at the origin of major health challenges and may cause pandemic threats. In the crusade for virus fight, being "small" may be an asset, for being active at the right scale. Nanosystems have recurrently been used to enhance the immune response of the body, by themselves or in combination with active agents (e.g. antigens) as well as for virus detection and isolation. This article is not an exhaustive review, but it envisions giving a general overview of the rationale behind the use of nanotechnology in virus fight, as illustrated by several significant examples including recent findings. Nanosystems, and in particular inorganic nanoparticles, offer a large variety of declinations that may be tailored in terms of physical and chemical characteristics to address the needs of virology. Among them, noble metals, metal oxides, mesoporous silica and calcium phosphates showed special promise. In particular, the bio-inspired character and modularity of calcium phosphates is appealing and allows envisioning further original developments in the fight against infections.

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DNA-triangular silver nanoparticles nanoprobe for the detection of dengue virus distinguishing serotype

Cited by 21 publications

References 12 publications

Recent Developments in Nanotechnology for Detection and Control of Aedes aegypti-Borne Diseases

Recent Developments in Nanotechnology for Detection and Control of Aedes aegypti-Borne Diseases

Mass Cytometry and Single‐Cell RNA‐seq Profiling of the Heterogeneity in Human Peripheral Blood Mononuclear Cells Interacting with Silver Nanoparticles

Nanotechnologies: A Key Role in Virus Fight

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