DNA Vaccines

Biering, Eirik; Salonius, Kira

doi:10.1002/9781118806913.ch5

Cited by 14 publications

(12 citation statements)

References 35 publications

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“…For oral vaccines as well, DNA preparations will come. However, acceptability in some regions such as Europe will depend on changes in legislation ( 90 ).…”

Section: Encapsulation Techniquesmentioning

confidence: 99%

Oral Vaccination of Fish – Antigen Preparations, Uptake, and Immune Induction

2015

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The oral route offers the most attractive approach of immunization of fish for a number of reasons: the ease of administration of antigens, it is less stressful than parenteral delivery and in principle, it is applicable to small and large sized fish; it also provides a procedure for oral boosting during grow-out periods in cages or ponds. There are, however, not many commercial vaccines available at the moment due to lack of efficacy and challenges associated with production of large quantities of antigens. These are required to stimulate an effective immune response locally and systemically, and need to be protected against degradation before they reach the sites where immune induction occurs. The hostile stomach environment is believed to be particularly important with regard to degradation of antigens in certain species. There is also a poor understanding about the requirements for proper immune induction following oral administration on one side, and the potential for induction of tolerance on the other. To what extent primary immunization via the oral route will elicit both local and systemic responses is not understood in detail. Furthermore, to what extent parenteral delivery will protect mucosal/gut surfaces and vice-versa is also not fully understood. We review the work that has been done on the subject and discuss it in light of recent advances that include mass production of antigens, including the use of plant systems. Different encapsulation techniques that have been developed in the quest to protect antigens against digestive degradation, as well as to target them for appropriate immune induction are also highlighted.

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“…For oral vaccines as well, DNA preparations will come. However, acceptability in some regions such as Europe will depend on changes in legislation ( 90 ).…”

Section: Encapsulation Techniquesmentioning

confidence: 99%

Oral Vaccination of Fish – Antigen Preparations, Uptake, and Immune Induction

2015

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“…Reclaimed terms such as 'Mad' did not translate well into some language groups (e.g. Icelandic: 'out of control') (Biering 2017).…”

Section: Introductionmentioning

confidence: 99%

‘It is meant to be heart rather than head’; International perspectives of teaching from lived experience in mental health nursing programs

Bocking

Happell

Scholz

et al. 2019

Int J Mental Health Nurs

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Consumer participation is a clear expectation of contemporary mental health policy. Most activity has concentrated in direct service delivery, and academic roles for mental health consumers have been slow to establish. An international project was undertaken to implement and evaluate meaningful consumer involvement in mental health nursing education. A learning module was co‐produced between ‘Experts by Experience’ (drawing on experience of mental distress and service use) and Mental Health Nurse Academics. This qualitative exploratory study aimed to capture how Experts by Experience perceive their contribution. Interviews were undertaken with Experts by Experience who delivered the learning module. Data were analysed thematically and subsequently interpreted with Critical Social Theory. Two main themes emerged from the findings: ‘there wasn't a barrier’ described how personal narratives enhanced relationships between Experts by Experience and students; and ‘made the human being visible’, described their experiences of allowing students to see the person behind a diagnosis. These findings suggest Experts by Experience teaching is valuable and potentially a tool in redressing stigma. Addressing poor public perceptions could attract higher numbers of quality practitioners to mental health and meet identified workforce shortages. The findings presented here strengthen the evidence base for Expert by Experience roles in mental health professional education. These findings can be considered in international curricula reviews and aid progress towards a more socio‐political, humanistic focus in mental health nursing, congruent with rights‐based reform agendas.

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“…Las vacunas DNA se basan en el uso de genes que codifican para uno o más antígenos que desencadenan una respuesta inmunitaria protectora cuando se expresan en los animales susceptibles al patógeno portador de dichos antígenos (Biering and Salonius, 2014).…”

Section: Inmunización Génetica: Vacunas Dnaunclassified

“…Sin embargo, todavía son pocas las vacunas antivirales seguras, eficaces y económicamente viables que han podido ser desarrolladas en acuicultura (Biering and Salonius, 2014). Se han realizado numerosos intentos por controlar la septicemia hemorrágica viral, tanto con vacunas inactivadas (Amend, 1976), atenuadas (De Kinkelin et al 1980), como con subunidades (Simon et al 2001).…”

Section: Justificación Propósito Y Objetivosunclassified

“…Sin embargo, son menos numerosos los estudios realizados in vitro para comprender las bases inmunológicas que confieren la protección antiviral (Biering and Salonius, 2014) y, sobre ese conocimiento, poder seleccionar nuevas vacunas DNA experimentales a partir de ensayos realizados en condiciones controladas y menos costosas que los experimentos in vivo y que permitan mejorar la inmunogenicidad y seguridad de este tipo de vacunas.…”

Section: Introductionunclassified

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Cultivos celulares para el desarrollo de vacunas DNA frente a virus de peces utilizando el modelo de trucha arco iris / rhabdovirus de la septicemia hemorrágica vírica (VHSV)

Haro¹

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DNA Vaccines

Cited by 14 publications

References 35 publications

Oral Vaccination of Fish – Antigen Preparations, Uptake, and Immune Induction

Oral Vaccination of Fish – Antigen Preparations, Uptake, and Immune Induction

‘It is meant to be heart rather than head’; International perspectives of teaching from lived experience in mental health nursing programs

Cultivos celulares para el desarrollo de vacunas DNA frente a virus de peces utilizando el modelo de trucha arco iris / rhabdovirus de la septicemia hemorrágica vírica (VHSV)

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