DNA viruses in human cancer: An integrated overview on fundamental mechanisms of viral carcinogenesis

Oliveira, Deílson Elgui de

doi:10.1016/j.canlet.2006.05.010

Cited by 81 publications

(78 citation statements)

References 109 publications

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“…Immunosuppression induced by these infections results in a higher frequency of tumors caused by other oncogenic viruses such as EBV, HPV and KSHV (zur Hausen, 2006;Elgui de Oliveira, 2007). These viruses belong to the Retroviridae family (Table 1) and, similar to HTLV-1, after infection, the viral RNA genome is converted into double-stranded DNA by a virally encoded reverse transcriptase.…”

Section: Human Immune Deficiency Virusesmentioning

confidence: 99%

Viral epigenomes in human tumorigenesis

Fernández

Esteller

2010

Oncogene

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Viruses are associated with 15-20% of human cancers worldwide. In the last century, many studies were directed towards elucidating the molecular mechanisms and genetic alterations by which viruses cause cancer. The importance of epigenetics in the regulation of gene expression has prompted the investigation of virus and host interactions not only at the genetic level but also at the epigenetic level. In this study, we summarize the published epigenetic information relating to the genomes of viruses directly or indirectly associated with the establishment of tumorigenic processes. We also review aspects such as viral replication and latency associated with epigenetic changes and summarize what is known about epigenetic alterations in host genomes and the implications of these for the tumoral process. The advances made in characterizing epigenetic features in cancer-causing viruses have improved our understanding of their functional mechanisms. Knowledge of the epigenetic changes that occur in the genome of these viruses should provide us with markers for following cancer progression, as well as new tools for cancer therapy.

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Section: Human Immune Deficiency Virusesmentioning

confidence: 99%

Viral epigenomes in human tumorigenesis

Fernández

Esteller

2010

Oncogene

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“…Human tumors have been attributed to both HHV-8 (Kaposi's sarcoma, primary effusion lymphoma [PEL], and multicentric Castleman's disease) and EBV (Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's and non-Hodgkin's lymphomas) [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

EBV-Associated Lymphoproliferative Disorders: Classification and Treatment

2008

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Since its discovery as the first human tumor virus, Epstein-Barr virus (EBV) has been implicated in the development of a wide range of B-cell lymphoproliferative disorders, including Burkitt's lymphoma, classic Hodgkin's lymphoma, and lymphomas arising in immunocompromised individuals (post-transplant and HIV-associated lymphoproliferative disorders). T-cell lymphoproliferative disorders that have been reported to be EBV associated include a subset of peripheral T-cell lymphomas, angioimmunoblastic Tcell lymphoma, extranodal nasal type natural killer/ T-cell lymphoma, and other rare histotypes. EBV encodes a series of products interacting with or exhibiting homology to a wide variety of antiapoptotic molecules, cytokines, and signal transducers, hence promoting EBV infection, immortalization, and transformation. However, the exact mechanism by which EBV promotes oncogenesis is an area of active debate. The focus of this review is on the pathology, diagnosis, classification, and pathogenesis of EBVassociated lymphomas. Recent advances in EBV cellbased immunotherapy, which is beginning to show promise in the treatment of EBV-related disorders, are discussed. The Oncologist 2008;13:577-585

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“…Further studies identified several other cancer-inducing human viruses and, in 1990, it was estimated that viruses and other infecting agents are associated with about 15% of all human cancer cases worldwide. 1 In addition to EBV, the most prominent human oncogenic DNA viruses are hepatitis B virus (HBV), human papilloma virus (HPV) and Kaposi sarcoma herpes virus (KSHV). Oncogenic retroviruses exist, too, and their role in human cancers has been discussed elsewhere.…”

Section: Introductionmentioning

confidence: 99%

“…Viral proteins interfere with the cellular microenvironment and impair communication with adjacent cells, ensuring a stable malignant phenotype and invasiveness of the host cell. 1 Other DNA viruses can cause malignant transformations in vitro, but their definite role in human cancer is not determined. This group includes several adenoviruses and polyomaviruses.…”

Section: Introductionmentioning

confidence: 99%

Presence and role of Simian Virus 40 (SV40) in malignant pleural mesothelioma

Hmeljak¹,

Cör²

2009

Radiology and Oncology

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Background. Evidence of a possible role of viruses in cancer first emerged in the early 1900s and was confirmed after the discovery of Epstein-Barr virus (EBV) in Conclusions. Simian virus 40 (SV40) is a small DNA virus from the genus polyomavirus, closely related to human polyomaviruses John Cunningham virus (JCV) and BK virus (BKV) and is highly oncogenic for rodents. The virus accidentally entered the human population through contaminated early batches of polio vaccine in the 1960s. After the discovery of SV40-like

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DNA viruses in human cancer: An integrated overview on fundamental mechanisms of viral carcinogenesis

Cited by 81 publications

References 109 publications

Viral epigenomes in human tumorigenesis

Viral epigenomes in human tumorigenesis

EBV-Associated Lymphoproliferative Disorders: Classification and Treatment

Presence and role of Simian Virus 40 (SV40) in malignant pleural mesothelioma

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