2022
DOI: 10.1101/2022.11.15.516569
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DNAJA2 and Hero11 mediate similar conformational extension and aggregation suppression of TDP-43

Abstract: Misfolding and aggregation of proteins are characteristic features in the progression of neurodegenerative diseases. While molecular chaperones are well-known suppressors of these aberrant events, we recently reported that a widespread family of heat-resistant obscure (Hero) proteins may also play a similar role. However, it is unclear how such electrostatically charged intrinsically disordered proteins protect client proteins from denaturation and aggregation. Here we utilize single-molecule FRET to monitor t… Show more

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